NDEL1 [The Human Chemical-Genetic Interaction Map Project]

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======= NDEL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDEL1
  * **<color #00a2e8>Official Name</color>**: nudE neurodevelopment protein 1 like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=81565|81565]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9GZM8|Q9GZM8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDEL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDEL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607538|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a coiled-coil protein that plays a role in multiple processes including cytoskeletal organization, cell signaling and neuron migration, outgrowth and maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Mar 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). {ECO:0000250|UniProtKB:Q9ERR1, ECO:0000269|PubMed:12556484, ECO:0000269|PubMed:14970193, ECO:0000269|PubMed:16291865, ECO:0000269|PubMed:17600710}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NUDE C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neurofilament cytoskeleton|
|oligopeptidase activity|
|central region of growth cone|
|mitotic centrosome separation|
|positive regulation of axon regeneration|
|axon hillock|
|neurofilament cytoskeleton organization|
|centrosome separation|
|positive regulation of neuron projection regeneration|
|regulation of microtubule motor activity|
|inner cell mass cell proliferation|
|positive regulation of ruffle assembly|
|membrane disassembly|
|nuclear envelope disassembly|
|blastocyst growth|
|retrograde axonal transport|
|microtubule nucleation|
|regulation of axon regeneration|
|establishment of mitotic spindle orientation|
|regulation of neuron projection regeneration|
|cerebral cortex radially oriented cell migration|
|centrosome localization|
|regulation of ruffle assembly|
|microtubule organizing center localization|
|microtubule polymerization|
|establishment of mitotic spindle localization|
|central nervous system neuron axonogenesis|
|establishment of spindle orientation|
|beta-tubulin binding|
|alpha-tubulin binding|
|cell leading edge|
|establishment of spindle localization|
|positive regulation of axon extension|
|cerebral cortex cell migration|
|vesicle transport along microtubule|
|lysosome localization|
|spindle localization|
|intermediate filament cytoskeleton organization|
|vesicle cytoskeletal trafficking|
|microtubule polymerization or depolymerization|
|intermediate filament-based process|
|kinesin complex|
|nuclear envelope organization|
|axonal transport|
|axon cytoplasm|
|telencephalon cell migration|
|neuron projection extension|
|forebrain cell migration|
|positive regulation of response to wounding|
|axo-dendritic transport|
|establishment of chromosome localization|
|chromosome localization|
|organelle transport along microtubule|
|central nervous system neuron development|
|centrosome cycle|
|kinetochore|
|positive regulation of axonogenesis|
|protein polymerization|
|developmental cell growth|
|insulin receptor signaling pathway|
|condensed chromosome kinetochore|
|cell growth|
|microtubule organizing center organization|
|regulation of axon extension|
|blastocyst development|
|activation of GTPase activity|
|positive regulation of plasma membrane bounded cell projection assembly|
|microtubule cytoskeleton organization involved in mitosis|
|regulation of extent of cell growth|
|developmental growth involved in morphogenesis|
|cerebral cortex development|
|establishment of cell polarity|
|synaptic vesicle|
|neuron migration|
|spindle|
|nucleus organization|
|mitotic nuclear division|
|positive regulation of cell morphogenesis involved in differentiation|
|transport along microtubule|
|cellular response to insulin stimulus|
|positive regulation of cell growth|
|regulation of response to wounding|
|positive regulation of developmental growth|
|pallium development|
|establishment of vesicle localization|
|cytoskeleton-dependent intracellular transport|
|nuclear envelope|
|central nervous system neuron differentiation|
|regulation of cell size|
|microtubule-based transport|
|regulation of axonogenesis|
|vesicle localization|
|establishment or maintenance of cell polarity|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|response to insulin|
|regulation of intracellular protein transport|
|microtubule binding|
|telencephalon development|
|positive regulation of growth|
|cellular response to peptide hormone stimulus|
|protein-containing complex binding|
|microtubule-based movement|
|chromosome segregation|
|positive regulation of neuron projection development|
|nuclear division|
|regulation of cell morphogenesis involved in differentiation|
|organelle fission|
|microtubule|
|cellular response to peptide|
|regulation of developmental growth|
|regulation of intracellular transport|
|establishment of organelle localization|
|positive regulation of neuron differentiation|
|axonogenesis|
|in utero embryonic development|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|forebrain development|
|developmental growth|
|response to peptide hormone|
|growth|
|cellular component disassembly|
|axon development|
|positive regulation of GTPase activity|
|regulation of cell growth|
|endomembrane system organization|
|cell morphogenesis involved in neuron differentiation|
|supramolecular fiber organization|
|positive regulation of neurogenesis|
|response to peptide|
|microtubule cytoskeleton organization|
|neuron projection morphogenesis|
|regulation of GTPase activity|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|centrosome|
|regulation of neuron projection development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of anatomical structure size|
|cell part morphogenesis|
|positive regulation of cellular component biogenesis|
|positive regulation of nervous system development|
|regulation of cellular protein localization|
|positive regulation of cell development|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|organelle localization|
|mitotic cell cycle process|
|cellular response to organonitrogen compound|
|positive regulation of response to external stimulus|
|cellular response to hormone stimulus|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|neuron projection development|
|microtubule-based process|
|regulation of growth|
|mitotic cell cycle|
|regulation of plasma membrane bounded cell projection organization|
|regulation of protein transport|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of cellular response to stress|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|positive regulation of hydrolase activity|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|cellular protein-containing complex assembly|
|membrane organization|
|response to hormone|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|cell cycle process|
|response to organonitrogen compound|
|neuron differentiation|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|regulation of response to external stimulus|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|proteolysis|
|regulation of hydrolase activity|
|locomotion|
|cell cycle|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|regulation of response to stress|
|intracellular transport|
|generation of neurons|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|-2.37|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.85|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12121
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDEL1 Expression in NALM6 Cells: 5.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>