NDUFA11 [The Human Chemical-Genetic Interaction Map Project]

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======= NDUFA11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFA11
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase subunit A11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=126328|126328]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86Y39|Q86Y39]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFA11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFA11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612638|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a subunit of the membrane-bound mitochondrial complex I. Complex I is composed of numerous subunits and functions as the NADH-ubiquinol reductase of the mitochondrial electron transport chain. Mutations in this gene are associated with severe mitochondrial complex I deficiency. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tim17|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial electron transport, NADH to ubiquinone|
|mitochondrial respiratory chain complex I|
|NADH dehydrogenase complex assembly|
|mitochondrial respiratory chain complex I assembly|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|respiratory electron transport chain|
|oxidative phosphorylation|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|oxidation-reduction process|
|mitochondrion|
|phosphorylation|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.7|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.72|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.73|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.78|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.81|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.82|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.85|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.86|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.87|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.87|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.97|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.02|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.02|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.03|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.09|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|2.28|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.64|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.68|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|3.08|
|[[:results:exp360|Genistein 15μM R07 exp360]]|3.29|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|3.46|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|4.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufa1|NDUFA1]]|0.691|
|[[:human genes:n:ndufa2|NDUFA2]]|0.68|
|[[:human genes:n:ndufs2|NDUFS2]]|0.677|
|[[:human genes:n:ndufb11|NDUFB11]]|0.671|
|[[:human genes:n:ndufc2|NDUFC2]]|0.665|
|[[:human genes:n:ndufb9|NDUFB9]]|0.661|
|[[:human genes:g:grsf1|GRSF1]]|0.654|
|[[:human genes:n:ndufc1|NDUFC1]]|0.636|
|[[:human genes:n:ndufa3|NDUFA3]]|0.631|
|[[:human genes:a:acad9|ACAD9]]|0.629|
|[[:human genes:n:nubpl|NUBPL]]|0.627|
|[[:human genes:n:ndufs7|NDUFS7]]|0.624|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.622|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.616|
|[[:human genes:n:ndufs5|NDUFS5]]|0.608|
|[[:human genes:n:ndufa6|NDUFA6]]|0.607|
|[[:human genes:f:fastkd2|FASTKD2]]|0.607|
|[[:human genes:n:ndufb6|NDUFB6]]|0.604|
|[[:human genes:m:mto1|MTO1]]|0.601|
|[[:human genes:n:ndufa8|NDUFA8]]|0.601|
|[[:human genes:e:ecsit|ECSIT]]|0.599|
|[[:human genes:n:ndufb10|NDUFB10]]|0.592|
|[[:human genes:n:ndufa10|NDUFA10]]|0.591|
|[[:human genes:n:ndufb5|NDUFB5]]|0.59|
|[[:human genes:n:ndufb7|NDUFB7]]|0.589|
|[[:human genes:n:ndufs1|NDUFS1]]|0.573|
|[[:human genes:n:ndufb2|NDUFB2]]|0.571|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.57|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.569|
|[[:human genes:c:chchd1|CHCHD1]]|0.566|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.565|
|[[:human genes:n:ndufv1|NDUFV1]]|0.556|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.554|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.552|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.55|
|[[:human genes:m:mrps21|MRPS21]]|0.546|
|[[:human genes:n:ndufv2|NDUFV2]]|0.54|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.54|
|[[:human genes:n:ndufb4|NDUFB4]]|0.535|
|[[:human genes:n:ndufa13|NDUFA13]]|0.535|
|[[:human genes:a:atp5sl|ATP5SL]]|0.528|
|[[:human genes:p:pet112|PET112]]|0.527|
|[[:human genes:m:mettl17|METTL17]]|0.527|
|[[:human genes:n:ndufs8|NDUFS8]]|0.525|
|[[:human genes:p:polg2|POLG2]]|0.523|
|[[:human genes:m:mrpl45|MRPL45]]|0.522|
|[[:human genes:c:coq7|COQ7]]|0.519|
|[[:human genes:n:ndufs3|NDUFS3]]|0.518|
|[[:human genes:f:foxred1|FOXRED1]]|0.518|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.516|
|[[:human genes:r:rpusd3|RPUSD3]]|0.512|
|[[:human genes:m:mrpl21|MRPL21]]|0.509|
|[[:human genes:f:ftsj2|FTSJ2]]|0.504|
|[[:human genes:r:rbfa|RBFA]]|0.502|
|[[:human genes:l:lars2|LARS2]]|0.5|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.499|
|[[:human genes:s:ssbp1|SSBP1]]|0.499|
|[[:human genes:t:tfb1m|TFB1M]]|0.496|
|[[:human genes:t:tmem261|TMEM261]]|0.496|
|[[:human genes:m:mrps28|MRPS28]]|0.494|
|[[:human genes:m:mtg1|MTG1]]|0.494|
|[[:human genes:n:nars2|NARS2]]|0.491|
|[[:human genes:g:gfm2|GFM2]]|0.486|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.485|
|[[:human genes:m:mrp63|MRP63]]|0.485|
|[[:human genes:c:c17orf89|C17orf89]]|0.484|
|[[:human genes:n:ndufa5|NDUFA5]]|0.48|
|[[:human genes:n:ndufb8|NDUFB8]]|0.48|
|[[:human genes:c:c12orf65|C12orf65]]|0.479|
|[[:human genes:m:mrpl44|MRPL44]]|0.478|
|[[:human genes:g:gfm1|GFM1]]|0.477|
|[[:human genes:m:mtif2|MTIF2]]|0.475|
|[[:human genes:m:mrpl15|MRPL15]]|0.475|
|[[:human genes:r:rpusd4|RPUSD4]]|0.474|
|[[:human genes:c:c10orf2|C10orf2]]|0.474|
|[[:human genes:y:yars2|YARS2]]|0.473|
|[[:human genes:t:tefm|TEFM]]|0.471|
|[[:human genes:m:mrpl13|MRPL13]]|0.471|
|[[:human genes:m:mrpl23|MRPL23]]|0.469|
|[[:human genes:p:pet117|PET117]]|0.469|
|[[:human genes:g:glrx5|GLRX5]]|0.466|
|[[:human genes:n:ndufb3|NDUFB3]]|0.464|
|[[:human genes:m:mrpl43|MRPL43]]|0.463|
|[[:human genes:c:cars2|CARS2]]|0.462|
|[[:human genes:w:wbscr16|WBSCR16]]|0.461|
|[[:human genes:q:qrsl1|QRSL1]]|0.46|
|[[:human genes:m:mterfd1|MTERFD1]]|0.459|
|[[:human genes:m:mrps6|MRPS6]]|0.459|
|[[:human genes:m:mrps5|MRPS5]]|0.457|
|[[:human genes:c:clpp|CLPP]]|0.453|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.452|
|[[:human genes:n:ndufa9|NDUFA9]]|0.451|
|[[:human genes:m:mrpl53|MRPL53]]|0.45|
|[[:human genes:d:dap3|DAP3]]|0.45|
|[[:human genes:m:mipep|MIPEP]]|0.449|
|[[:human genes:m:mrps12|MRPS12]]|0.449|
|[[:human genes:n:nfu1|NFU1]]|0.449|
|[[:human genes:m:mrps33|MRPS33]]|0.448|
|[[:human genes:i:ict1|ICT1]]|0.448|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.447|
|[[:human genes:c:coq2|COQ2]]|0.446|
|[[:human genes:c:cox16|COX16]]|0.446|
|[[:human genes:m:mrpl47|MRPL47]]|0.444|
|[[:human genes:s:slc25a3|SLC25A3]]|0.442|
|[[:human genes:m:mrpl17|MRPL17]]|0.441|
|[[:human genes:s:selrc1|SELRC1]]|0.441|
|[[:human genes:a:alas1|ALAS1]]|0.439|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.439|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.438|
|[[:human genes:m:mrpl1|MRPL1]]|0.437|
|[[:human genes:c:c1qbp|C1QBP]]|0.435|
|[[:human genes:a:aifm1|AIFM1]]|0.434|
|[[:human genes:p:pars2|PARS2]]|0.432|
|[[:human genes:e:ears2|EARS2]]|0.431|
|[[:human genes:m:mrpl3|MRPL3]]|0.428|
|[[:human genes:t:tars2|TARS2]]|0.428|
|[[:human genes:m:mrps23|MRPS23]]|0.427|
|[[:human genes:c:coq4|COQ4]]|0.426|
|[[:human genes:m:mrpl12|MRPL12]]|0.426|
|[[:human genes:t:tufm|TUFM]]|0.426|
|[[:human genes:m:mrps16|MRPS16]]|0.425|
|[[:human genes:m:mtg2|MTG2]]|0.425|
|[[:human genes:e:eral1|ERAL1]]|0.425|
|[[:human genes:p:pdss1|PDSS1]]|0.424|
|[[:human genes:m:mrps27|MRPS27]]|0.424|
|[[:human genes:t:tomm7|TOMM7]]|0.424|
|[[:human genes:t:timm21|TIMM21]]|0.424|
|[[:human genes:r:rmnd1|RMND1]]|0.423|
|[[:human genes:i:iba57|IBA57]]|0.422|
|[[:human genes:n:noa1|NOA1]]|0.421|
|[[:human genes:f:fars2|FARS2]]|0.42|
|[[:human genes:s:sco2|SCO2]]|0.42|
|[[:human genes:m:malsu1|MALSU1]]|0.42|
|[[:human genes:m:mrps26|MRPS26]]|0.419|
|[[:human genes:a:aars2|AARS2]]|0.419|
|[[:human genes:m:mrps14|MRPS14]]|0.418|
|[[:human genes:m:mars2|MARS2]]|0.416|
|[[:human genes:d:dars2|DARS2]]|0.416|
|[[:human genes:p:pnpt1|PNPT1]]|0.413|
|[[:human genes:s:sfxn4|SFXN4]]|0.412|
|[[:human genes:m:mrps18b|MRPS18B]]|0.412|
|[[:human genes:m:mrpl4|MRPL4]]|0.409|
|[[:human genes:t:trmt10c|TRMT10C]]|0.407|
|[[:human genes:p:polrmt|POLRMT]]|0.403|
|[[:human genes:t:trub2|TRUB2]]|0.403|
|[[:human genes:p:polg|POLG]]|0.4|
|[[:human genes:n:nsun4|NSUN4]]|0.4|
|[[:human genes:g:gatc|GATC]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 55/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|1/28|
|bone|1/26|
|breast|6/33|
|central nervous system|1/56|
|cervix|1/4|
|colorectal|3/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|5/16|
|kidney|2/21|
|liver|3/20|
|lung|5/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 446
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFA11 Expression in NALM6 Cells: 5.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>