NDUFA1 [The Human Chemical-Genetic Interaction Map Project]

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======= NDUFA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFA1
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase subunit A1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4694|4694]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15239|O15239]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300078|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. It has been noted that the N-terminal hydrophobic domain has the potential to be folded into an alpha-helix spanning the inner mitochondrial membrane with a C-terminal hydrophilic domain interacting with globular subunits of complex I. The highly conserved two-domain structure suggests that this feature is critical for the protein function and might act as an anchor for the NADH:ubiquinone oxidoreductase complex at the inner mitochondrial membrane. However, the NDUFA1 peptide is one of about 31 components of the 'hydrophobic protein' (HP) fraction of complex I which is involved in proton translocation. Thus the NDUFA1 peptide may also participate in that function. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NADH dehydrogenase (ubiquinone) activity|
|mitochondrial electron transport, NADH to ubiquinone|
|mitochondrial respiratory chain complex I|
|NADH dehydrogenase complex assembly|
|mitochondrial respiratory chain complex I assembly|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|mitochondrial membrane|
|respiratory electron transport chain|
|oxidative phosphorylation|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|oxidation-reduction process|
|mitochondrion|
|phosphorylation|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|-1.7|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.7|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.7|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.71|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.74|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.75|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|1.76|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.78|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|1.87|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.89|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.94|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.94|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.98|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|1.99|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.05|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.06|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.06|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|2.11|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.17|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.19|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.19|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|2.23|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.29|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.31|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|2.32|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.38|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.42|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.43|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.63|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.63|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.66|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.77|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|3.68|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|4.17|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|5.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufb9|NDUFB9]]|0.753|
|[[:human genes:n:ndufb11|NDUFB11]]|0.741|
|[[:human genes:n:ndufc2|NDUFC2]]|0.718|
|[[:human genes:a:acad9|ACAD9]]|0.717|
|[[:human genes:n:ndufa3|NDUFA3]]|0.709|
|[[:human genes:n:ndufs2|NDUFS2]]|0.708|
|[[:human genes:n:ndufa11|NDUFA11]]|0.691|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.684|
|[[:human genes:g:grsf1|GRSF1]]|0.671|
|[[:human genes:n:ndufa2|NDUFA2]]|0.665|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.661|
|[[:human genes:n:ndufs5|NDUFS5]]|0.652|
|[[:human genes:n:ndufb5|NDUFB5]]|0.65|
|[[:human genes:n:nubpl|NUBPL]]|0.641|
|[[:human genes:n:ndufv1|NDUFV1]]|0.641|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.639|
|[[:human genes:n:ndufb4|NDUFB4]]|0.638|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.638|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.638|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.633|
|[[:human genes:m:mto1|MTO1]]|0.632|
|[[:human genes:n:ndufb7|NDUFB7]]|0.629|
|[[:human genes:n:ndufs7|NDUFS7]]|0.61|
|[[:human genes:e:ecsit|ECSIT]]|0.61|
|[[:human genes:m:mrpl45|MRPL45]]|0.609|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.607|
|[[:human genes:n:ndufc1|NDUFC1]]|0.605|
|[[:human genes:n:ndufa8|NDUFA8]]|0.605|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.605|
|[[:human genes:n:ndufb6|NDUFB6]]|0.603|
|[[:human genes:m:mrp63|MRP63]]|0.595|
|[[:human genes:n:ndufa10|NDUFA10]]|0.59|
|[[:human genes:l:lars2|LARS2]]|0.587|
|[[:human genes:g:gfm1|GFM1]]|0.581|
|[[:human genes:f:ftsj2|FTSJ2]]|0.58|
|[[:human genes:n:nars2|NARS2]]|0.576|
|[[:human genes:n:ndufs1|NDUFS1]]|0.575|
|[[:human genes:n:ndufa6|NDUFA6]]|0.572|
|[[:human genes:r:rpusd3|RPUSD3]]|0.571|
|[[:human genes:d:dars2|DARS2]]|0.57|
|[[:human genes:q:qrsl1|QRSL1]]|0.569|
|[[:human genes:d:dap3|DAP3]]|0.566|
|[[:human genes:n:ndufs3|NDUFS3]]|0.565|
|[[:human genes:w:wbscr16|WBSCR16]]|0.565|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.564|
|[[:human genes:y:yars2|YARS2]]|0.563|
|[[:human genes:c:cars2|CARS2]]|0.561|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.561|
|[[:human genes:c:chchd1|CHCHD1]]|0.561|
|[[:human genes:m:mrpl21|MRPL21]]|0.56|
|[[:human genes:n:ndufb8|NDUFB8]]|0.56|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.56|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.556|
|[[:human genes:f:fastkd2|FASTKD2]]|0.555|
|[[:human genes:m:mrps21|MRPS21]]|0.55|
|[[:human genes:n:ndufa13|NDUFA13]]|0.55|
|[[:human genes:a:atp5sl|ATP5SL]]|0.546|
|[[:human genes:m:mrpl3|MRPL3]]|0.539|
|[[:human genes:t:tfb1m|TFB1M]]|0.538|
|[[:human genes:n:ndufb10|NDUFB10]]|0.537|
|[[:human genes:n:nfu1|NFU1]]|0.537|
|[[:human genes:f:foxred1|FOXRED1]]|0.536|
|[[:human genes:n:ndufa5|NDUFA5]]|0.536|
|[[:human genes:n:ndufs8|NDUFS8]]|0.533|
|[[:human genes:n:ndufa9|NDUFA9]]|0.533|
|[[:human genes:m:mterfd1|MTERFD1]]|0.533|
|[[:human genes:s:ssbp1|SSBP1]]|0.531|
|[[:human genes:g:gfm2|GFM2]]|0.529|
|[[:human genes:n:ndufb2|NDUFB2]]|0.526|
|[[:human genes:t:tmem261|TMEM261]]|0.524|
|[[:human genes:p:pet117|PET117]]|0.524|
|[[:human genes:m:mrpl20|MRPL20]]|0.523|
|[[:human genes:m:mtif2|MTIF2]]|0.523|
|[[:human genes:c:coq7|COQ7]]|0.52|
|[[:human genes:p:pet112|PET112]]|0.52|
|[[:human genes:t:tars2|TARS2]]|0.519|
|[[:human genes:m:mrps5|MRPS5]]|0.518|
|[[:human genes:a:atp5c1|ATP5C1]]|0.516|
|[[:human genes:e:eral1|ERAL1]]|0.516|
|[[:human genes:m:mrps16|MRPS16]]|0.516|
|[[:human genes:c:c1qbp|C1QBP]]|0.514|
|[[:human genes:m:mrps25|MRPS25]]|0.511|
|[[:human genes:m:mrps6|MRPS6]]|0.511|
|[[:human genes:r:rbfa|RBFA]]|0.51|
|[[:human genes:i:iba57|IBA57]]|0.51|
|[[:human genes:m:mrps33|MRPS33]]|0.51|
|[[:human genes:t:trub2|TRUB2]]|0.509|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.505|
|[[:human genes:c:c17orf89|C17orf89]]|0.504|
|[[:human genes:m:mtg1|MTG1]]|0.503|
|[[:human genes:m:mrpl53|MRPL53]]|0.501|
|[[:human genes:m:mrps26|MRPS26]]|0.498|
|[[:human genes:m:mrpl23|MRPL23]]|0.498|
|[[:human genes:c:c12orf65|C12orf65]]|0.497|
|[[:human genes:m:mrps34|MRPS34]]|0.497|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.496|
|[[:human genes:c:c10orf2|C10orf2]]|0.496|
|[[:human genes:t:tufm|TUFM]]|0.495|
|[[:human genes:m:mrpl43|MRPL43]]|0.495|
|[[:human genes:s:selrc1|SELRC1]]|0.495|
|[[:human genes:g:glrx5|GLRX5]]|0.494|
|[[:human genes:m:mettl17|METTL17]]|0.494|
|[[:human genes:t:tefm|TEFM]]|0.493|
|[[:human genes:p:pars2|PARS2]]|0.491|
|[[:human genes:m:mrps14|MRPS14]]|0.489|
|[[:human genes:m:mrps27|MRPS27]]|0.488|
|[[:human genes:b:bcs1l|BCS1L]]|0.488|
|[[:human genes:r:rpusd4|RPUSD4]]|0.487|
|[[:human genes:p:pnpt1|PNPT1]]|0.487|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.486|
|[[:human genes:m:mrpl47|MRPL47]]|0.486|
|[[:human genes:v:vars2|VARS2]]|0.485|
|[[:human genes:a:aifm1|AIFM1]]|0.485|
|[[:human genes:m:mars2|MARS2]]|0.483|
|[[:human genes:m:malsu1|MALSU1]]|0.483|
|[[:human genes:a:atp5d|ATP5D]]|0.482|
|[[:human genes:m:mrpl44|MRPL44]]|0.482|
|[[:human genes:a:atp5e|ATP5E]]|0.481|
|[[:human genes:p:polg2|POLG2]]|0.48|
|[[:human genes:n:ndufv2|NDUFV2]]|0.479|
|[[:human genes:m:mrps23|MRPS23]]|0.477|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.477|
|[[:human genes:a:aars2|AARS2]]|0.476|
|[[:human genes:t:timm21|TIMM21]]|0.475|
|[[:human genes:p:polg|POLG]]|0.474|
|[[:human genes:r:rars2|RARS2]]|0.473|
|[[:human genes:t:tfam|TFAM]]|0.473|
|[[:human genes:m:mrps12|MRPS12]]|0.471|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.47|
|[[:human genes:n:ndufb3|NDUFB3]]|0.47|
|[[:human genes:s:slc25a51|SLC25A51]]|0.468|
|[[:human genes:m:mrpl22|MRPL22]]|0.467|
|[[:human genes:m:mrpl13|MRPL13]]|0.466|
|[[:human genes:m:mrps9|MRPS9]]|0.466|
|[[:human genes:s:slc25a3|SLC25A3]]|0.465|
|[[:human genes:m:mcat|MCAT]]|0.464|
|[[:human genes:w:wars2|WARS2]]|0.464|
|[[:human genes:c:cox16|COX16]]|0.463|
|[[:human genes:g:gatc|GATC]]|0.463|
|[[:human genes:s:slc25a26|SLC25A26]]|0.461|
|[[:human genes:c:clpp|CLPP]]|0.46|
|[[:human genes:e:ears2|EARS2]]|0.459|
|[[:human genes:p:polrmt|POLRMT]]|0.458|
|[[:human genes:s:slc25a52|SLC25A52]]|0.458|
|[[:human genes:t:trmt10c|TRMT10C]]|0.458|
|[[:human genes:s:sco2|SCO2]]|0.457|
|[[:human genes:o:oma1|OMA1]]|0.453|
|[[:human genes:m:mrpl17|MRPL17]]|0.453|
|[[:human genes:m:mrpl15|MRPL15]]|0.45|
|[[:human genes:c:coq2|COQ2]]|0.447|
|[[:human genes:n:nsun4|NSUN4]]|0.446|
|[[:human genes:m:mipep|MIPEP]]|0.446|
|[[:human genes:f:fars2|FARS2]]|0.444|
|[[:human genes:f:fastkd5|FASTKD5]]|0.444|
|[[:human genes:i:isca2|ISCA2]]|0.443|
|[[:human genes:p:ptcd3|PTCD3]]|0.44|
|[[:human genes:c:coa6|COA6]]|0.44|
|[[:human genes:d:ddx28|DDX28]]|0.439|
|[[:human genes:m:mrps18b|MRPS18B]]|0.437|
|[[:human genes:n:noa1|NOA1]]|0.435|
|[[:human genes:c:coa3|COA3]]|0.435|
|[[:human genes:m:mrpl12|MRPL12]]|0.433|
|[[:human genes:n:ndufb1|NDUFB1]]|0.433|
|[[:human genes:c:cox7b|COX7B]]|0.431|
|[[:human genes:h:hars2|HARS2]]|0.431|
|[[:human genes:m:mrpl42|MRPL42]]|0.43|
|[[:human genes:m:mrps22|MRPS22]]|0.427|
|[[:human genes:m:mrps35|MRPS35]]|0.426|
|[[:human genes:a:atp5a1|ATP5A1]]|0.423|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.422|
|[[:human genes:m:mtg2|MTG2]]|0.42|
|[[:human genes:c:cox19|COX19]]|0.419|
|[[:human genes:p:pdss2|PDSS2]]|0.418|
|[[:human genes:m:mrps7|MRPS7]]|0.416|
|[[:human genes:p:pdss1|PDSS1]]|0.416|
|[[:human genes:s:sars2|SARS2]]|0.416|
|[[:human genes:h:higd2a|HIGD2A]]|0.415|
|[[:human genes:s:sfxn4|SFXN4]]|0.415|
|[[:human genes:i:ict1|ICT1]]|0.414|
|[[:human genes:t:tomm22|TOMM22]]|0.414|
|[[:human genes:m:mrpl1|MRPL1]]|0.412|
|[[:human genes:m:mrps10|MRPS10]]|0.411|
|[[:human genes:t:tomm20|TOMM20]]|0.41|
|[[:human genes:s:slc25a19|SLC25A19]]|0.41|
|[[:human genes:m:mterfd2|MTERFD2]]|0.41|
|[[:human genes:m:mrps18a|MRPS18A]]|0.409|
|[[:human genes:m:mrpl49|MRPL49]]|0.408|
|[[:human genes:c:cox6b1|COX6B1]]|0.408|
|[[:human genes:m:mrps17|MRPS17]]|0.407|
|[[:human genes:m:mrpl39|MRPL39]]|0.407|
|[[:human genes:t:tomm6|TOMM6]]|0.406|
|[[:human genes:m:mrpl18|MRPL18]]|0.404|
|[[:human genes:p:pde12|PDE12]]|0.402|
|[[:human genes:m:mrps2|MRPS2]]|0.402|
|[[:human genes:m:mrpl33|MRPL33]]|0.4|
|[[:human genes:r:rmnd1|RMND1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 7/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|2/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|1/14|
|kidney|0/18|
|liver|0/19|
|lung|1/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 261
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFA1 Expression in NALM6 Cells: 5.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>