NDUFA5 [The Human Chemical-Genetic Interaction Map Project]

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======= NDUFA5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFA5
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase subunit A5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4698|4698]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16718|Q16718]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFA5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFA5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601677|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ETC C1 NDUFA5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NADH dehydrogenase (ubiquinone) activity|
|mitochondrial electron transport, NADH to ubiquinone|
|mitochondrial respiratory chain complex I|
|mitochondrial respiratory chain complex I assembly|
|NADH dehydrogenase complex assembly|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|respiratory electron transport chain|
|oxidative phosphorylation|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|oxidation-reduction process|
|phosphorylation|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.85|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.97|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2.49|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufc2|NDUFC2]]|0.554|
|[[:human genes:n:ndufa1|NDUFA1]]|0.536|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.527|
|[[:human genes:n:ndufa3|NDUFA3]]|0.525|
|[[:human genes:n:ndufs2|NDUFS2]]|0.514|
|[[:human genes:n:nubpl|NUBPL]]|0.503|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.498|
|[[:human genes:n:ndufb11|NDUFB11]]|0.491|
|[[:human genes:n:ndufb9|NDUFB9]]|0.488|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.487|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.485|
|[[:human genes:g:grsf1|GRSF1]]|0.483|
|[[:human genes:m:mto1|MTO1]]|0.483|
|[[:human genes:n:ndufa2|NDUFA2]]|0.481|
|[[:human genes:n:ndufa11|NDUFA11]]|0.48|
|[[:human genes:n:ndufb3|NDUFB3]]|0.477|
|[[:human genes:n:ndufb4|NDUFB4]]|0.47|
|[[:human genes:m:mrpl45|MRPL45]]|0.464|
|[[:human genes:n:ndufv1|NDUFV1]]|0.463|
|[[:human genes:n:ndufb7|NDUFB7]]|0.46|
|[[:human genes:n:ndufb5|NDUFB5]]|0.453|
|[[:human genes:n:ndufb6|NDUFB6]]|0.451|
|[[:human genes:n:ndufs5|NDUFS5]]|0.448|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.44|
|[[:human genes:n:ndufc1|NDUFC1]]|0.435|
|[[:human genes:t:tmem261|TMEM261]]|0.431|
|[[:human genes:a:acad9|ACAD9]]|0.428|
|[[:human genes:n:ndufa8|NDUFA8]]|0.424|
|[[:human genes:n:ndufs7|NDUFS7]]|0.422|
|[[:human genes:n:nfu1|NFU1]]|0.416|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.415|
|[[:human genes:t:tufm|TUFM]]|0.415|
|[[:human genes:g:gfm1|GFM1]]|0.415|
|[[:human genes:m:mrpl47|MRPL47]]|0.413|
|[[:human genes:c:cox6b1|COX6B1]]|0.413|
|[[:human genes:n:ndufa13|NDUFA13]]|0.409|
|[[:human genes:g:gfm2|GFM2]]|0.407|
|[[:human genes:p:pnpt1|PNPT1]]|0.407|
|[[:human genes:c:chchd1|CHCHD1]]|0.406|
|[[:human genes:c:cars2|CARS2]]|0.406|
|[[:human genes:f:foxred1|FOXRED1]]|0.405|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.403|
|[[:human genes:t:tfb1m|TFB1M]]|0.403|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.402|
|[[:human genes:n:ndufa6|NDUFA6]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2714
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFA5 Expression in NALM6 Cells: 5.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>