NDUFA8 [The Human Chemical-Genetic Interaction Map Project]

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======= NDUFA8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFA8
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase subunit A8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4702|4702]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51970|P51970]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFA8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFA8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603359|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the complex I 19 kDa subunit family. Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays an important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CHCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NADH dehydrogenase (ubiquinone) activity|
|mitochondrial electron transport, NADH to ubiquinone|
|mitochondrial respiratory chain complex I|
|NADH dehydrogenase complex assembly|
|mitochondrial respiratory chain complex I assembly|
|mitochondrial intermembrane space|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|respiratory electron transport chain|
|oxidative phosphorylation|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|protein-containing complex binding|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|oxidation-reduction process|
|mitochondrion|
|phosphorylation|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.03|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.03|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.14|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.32|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufs2|NDUFS2]]|0.628|
|[[:human genes:n:ndufb11|NDUFB11]]|0.624|
|[[:human genes:n:ndufa2|NDUFA2]]|0.617|
|[[:human genes:g:grsf1|GRSF1]]|0.614|
|[[:human genes:n:ndufa1|NDUFA1]]|0.605|
|[[:human genes:n:ndufb9|NDUFB9]]|0.604|
|[[:human genes:n:ndufa11|NDUFA11]]|0.601|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.601|
|[[:human genes:a:acad9|ACAD9]]|0.6|
|[[:human genes:n:ndufa3|NDUFA3]]|0.585|
|[[:human genes:m:mto1|MTO1]]|0.571|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.571|
|[[:human genes:n:ndufs7|NDUFS7]]|0.567|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.563|
|[[:human genes:e:ecsit|ECSIT]]|0.554|
|[[:human genes:n:nubpl|NUBPL]]|0.55|
|[[:human genes:n:ndufa6|NDUFA6]]|0.535|
|[[:human genes:n:ndufb5|NDUFB5]]|0.534|
|[[:human genes:n:ndufb6|NDUFB6]]|0.533|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.531|
|[[:human genes:n:ndufb7|NDUFB7]]|0.525|
|[[:human genes:n:ndufc2|NDUFC2]]|0.521|
|[[:human genes:n:ndufv2|NDUFV2]]|0.52|
|[[:human genes:n:ndufb2|NDUFB2]]|0.515|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.513|
|[[:human genes:n:ndufs5|NDUFS5]]|0.513|
|[[:human genes:n:ndufs8|NDUFS8]]|0.511|
|[[:human genes:p:polg|POLG]]|0.501|
|[[:human genes:n:ndufa10|NDUFA10]]|0.501|
|[[:human genes:n:ndufa13|NDUFA13]]|0.497|
|[[:human genes:m:mrps27|MRPS27]]|0.493|
|[[:human genes:t:tmem261|TMEM261]]|0.49|
|[[:human genes:m:mettl17|METTL17]]|0.487|
|[[:human genes:p:pet117|PET117]]|0.482|
|[[:human genes:n:ndufb4|NDUFB4]]|0.478|
|[[:human genes:p:polg2|POLG2]]|0.477|
|[[:human genes:f:fastkd2|FASTKD2]]|0.476|
|[[:human genes:f:ftsj2|FTSJ2]]|0.475|
|[[:human genes:n:ndufv1|NDUFV1]]|0.474|
|[[:human genes:n:nars2|NARS2]]|0.47|
|[[:human genes:n:ndufb10|NDUFB10]]|0.469|
|[[:human genes:n:ndufa9|NDUFA9]]|0.467|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.465|
|[[:human genes:a:atp5sl|ATP5SL]]|0.455|
|[[:human genes:m:mcat|MCAT]]|0.454|
|[[:human genes:p:pet112|PET112]]|0.452|
|[[:human genes:i:iba57|IBA57]]|0.452|
|[[:human genes:m:mrpl45|MRPL45]]|0.452|
|[[:human genes:g:gfm2|GFM2]]|0.451|
|[[:human genes:n:ndufs1|NDUFS1]]|0.45|
|[[:human genes:l:lars2|LARS2]]|0.449|
|[[:human genes:f:foxred1|FOXRED1]]|0.448|
|[[:human genes:c:cars2|CARS2]]|0.446|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.446|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.445|
|[[:human genes:c:c12orf65|C12orf65]]|0.444|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.443|
|[[:human genes:m:mrpl21|MRPL21]]|0.443|
|[[:human genes:n:ndufc1|NDUFC1]]|0.443|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.441|
|[[:human genes:m:mipep|MIPEP]]|0.44|
|[[:human genes:s:slc25a51|SLC25A51]]|0.44|
|[[:human genes:r:rmnd1|RMND1]]|0.439|
|[[:human genes:q:qrsl1|QRSL1]]|0.439|
|[[:human genes:m:mrps21|MRPS21]]|0.435|
|[[:human genes:n:ndufb3|NDUFB3]]|0.434|
|[[:human genes:n:ndufs3|NDUFS3]]|0.433|
|[[:human genes:c:coq2|COQ2]]|0.433|
|[[:human genes:p:polrmt|POLRMT]]|0.433|
|[[:human genes:r:rpusd3|RPUSD3]]|0.43|
|[[:human genes:g:gfm1|GFM1]]|0.427|
|[[:human genes:y:yars2|YARS2]]|0.427|
|[[:human genes:c:clpp|CLPP]]|0.425|
|[[:human genes:n:ndufa5|NDUFA5]]|0.424|
|[[:human genes:n:ndufb8|NDUFB8]]|0.422|
|[[:human genes:e:ears2|EARS2]]|0.421|
|[[:human genes:c:coq7|COQ7]]|0.42|
|[[:human genes:m:malsu1|MALSU1]]|0.416|
|[[:human genes:s:ssbp1|SSBP1]]|0.416|
|[[:human genes:m:mrpl15|MRPL15]]|0.414|
|[[:human genes:p:prepl|PREPL]]|0.413|
|[[:human genes:c:chchd1|CHCHD1]]|0.412|
|[[:human genes:m:mrpl43|MRPL43]]|0.41|
|[[:human genes:r:rbfa|RBFA]]|0.409|
|[[:human genes:s:slc25a3|SLC25A3]]|0.409|
|[[:human genes:w:wars2|WARS2]]|0.407|
|[[:human genes:w:wbscr16|WBSCR16]]|0.407|
|[[:human genes:m:mrps6|MRPS6]]|0.406|
|[[:human genes:m:mrpl12|MRPL12]]|0.406|
|[[:human genes:t:tefm|TEFM]]|0.406|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.405|
|[[:human genes:n:noa1|NOA1]]|0.405|
|[[:human genes:i:ict1|ICT1]]|0.405|
|[[:human genes:v:vars2|VARS2]]|0.403|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.403|
|[[:human genes:c:c17orf89|C17orf89]]|0.403|
|[[:human genes:m:mtg1|MTG1]]|0.402|
|[[:human genes:m:mrps25|MRPS25]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 72/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|4/28|
|bone|2/26|
|breast|4/33|
|central nervous system|2/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|4/21|
|liver|5/20|
|lung|9/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|2/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1905
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFA8 Expression in NALM6 Cells: 4.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>