NDUFAB1 [The Human Chemical-Genetic Interaction Map Project]

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======= NDUFAB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFAB1
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase subunit AB1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4706|4706]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14561|O14561]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFAB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFAB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603836|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (PubMed:27626371). {ECO:0000250|UniProtKB:P52505, ECO:0000269|PubMed:27626371}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PP-binding|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|acyl carrier activity|
|acyl binding|
|protein lipoylation|
|protein-cofactor linkage|
|fatty acid binding|
|NADH dehydrogenase (ubiquinone) activity|
|mitochondrial electron transport, NADH to ubiquinone|
|mitochondrial respiratory chain complex I|
|mitochondrial large ribosomal subunit|
|mitochondrial respiratory chain complex I assembly|
|NADH dehydrogenase complex assembly|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|mitochondrial membrane|
|respiratory electron transport chain|
|oxidative phosphorylation|
|fatty acid biosynthetic process|
|cellular respiration|
|electron transport chain|
|monocarboxylic acid biosynthetic process|
|ATP metabolic process|
|protein maturation|
|energy derivation by oxidation of organic compounds|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|peptidyl-lysine modification|
|fatty acid metabolic process|
|mitochondrial matrix|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|monocarboxylic acid metabolic process|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|calcium ion binding|
|cellular protein-containing complex assembly|
|peptidyl-amino acid modification|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|lipid metabolic process|
|mitochondrion|
|phosphorylation|
|protein-containing complex assembly|
|small molecule metabolic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 162/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|5/28|
|blood|2/28|
|bone|3/26|
|breast|13/33|
|central nervous system|13/56|
|cervix|2/4|
|colorectal|3/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|3/21|
|liver|6/20|
|lung|18/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|4/24|
|peripheral nervous system|3/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|8/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|3/22|
|urinary tract|6/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 720
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFAB1 Expression in NALM6 Cells: 5.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>