NDUFAF1 [The Human Chemical-Genetic Interaction Map Project]

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======= NDUFAF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFAF1
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase complex assembly factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51103|51103]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y375|Q9Y375]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFAF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFAF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606934|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a complex I assembly factor protein. Complex I (NADH-ubiquinone oxidoreductase) catalyzes the transfer of electrons from NADH to ubiquinone (coenzyme Q) in the first step of the mitochondrial respiratory chain, resulting in the translocation of protons across the inner mitochondrial membrane. The encoded protein is required for assembly of complex I, and mutations in this gene are a cause of mitochondrial complex I deficiency. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 19. [provided by RefSeq, Dec 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CIA30|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial electron transport, NADH to ubiquinone|
|mitochondrial respiratory chain complex I|
|mitochondrial respiratory chain complex I assembly|
|NADH dehydrogenase complex assembly|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|respiratory electron transport chain|
|oxidative phosphorylation|
|unfolded protein binding|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial matrix|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|oxidation-reduction process|
|mitochondrion|
|phosphorylation|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.38|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-2.15|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-2.12|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.73|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.78|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.92|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.92|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.98|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.38|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.54|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufb9|NDUFB9]]|0.623|
|[[:human genes:n:ndufa1|NDUFA1]]|0.605|
|[[:human genes:n:ndufc2|NDUFC2]]|0.588|
|[[:human genes:a:acad9|ACAD9]]|0.583|
|[[:human genes:n:ndufb11|NDUFB11]]|0.569|
|[[:human genes:n:ndufb5|NDUFB5]]|0.553|
|[[:human genes:n:ndufa11|NDUFA11]]|0.55|
|[[:human genes:g:grsf1|GRSF1]]|0.545|
|[[:human genes:m:mto1|MTO1]]|0.533|
|[[:human genes:n:ndufa2|NDUFA2]]|0.531|
|[[:human genes:n:ndufb6|NDUFB6]]|0.524|
|[[:human genes:n:ndufb10|NDUFB10]]|0.514|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.511|
|[[:human genes:m:mtif2|MTIF2]]|0.511|
|[[:human genes:n:nubpl|NUBPL]]|0.511|
|[[:human genes:n:ndufc1|NDUFC1]]|0.51|
|[[:human genes:n:ndufa10|NDUFA10]]|0.506|
|[[:human genes:n:ndufb7|NDUFB7]]|0.505|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.502|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.502|
|[[:human genes:p:pet112|PET112]]|0.491|
|[[:human genes:t:tfb1m|TFB1M]]|0.491|
|[[:human genes:c:c17orf89|C17orf89]]|0.491|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.49|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.49|
|[[:human genes:n:ndufs8|NDUFS8]]|0.488|
|[[:human genes:n:ndufs2|NDUFS2]]|0.482|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.481|
|[[:human genes:e:ecsit|ECSIT]]|0.478|
|[[:human genes:l:lars2|LARS2]]|0.476|
|[[:human genes:f:fastkd2|FASTKD2]]|0.475|
|[[:human genes:n:ndufa3|NDUFA3]]|0.472|
|[[:human genes:m:mrpl45|MRPL45]]|0.47|
|[[:human genes:n:ndufb4|NDUFB4]]|0.469|
|[[:human genes:g:gfm2|GFM2]]|0.464|
|[[:human genes:q:qrsl1|QRSL1]]|0.463|
|[[:human genes:m:mterfd1|MTERFD1]]|0.463|
|[[:human genes:t:tmem261|TMEM261]]|0.461|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.461|
|[[:human genes:f:ftsj2|FTSJ2]]|0.46|
|[[:human genes:n:ndufa6|NDUFA6]]|0.459|
|[[:human genes:c:chchd1|CHCHD1]]|0.454|
|[[:human genes:n:nars2|NARS2]]|0.454|
|[[:human genes:n:ndufs5|NDUFS5]]|0.453|
|[[:human genes:n:ndufs1|NDUFS1]]|0.453|
|[[:human genes:a:atp5sl|ATP5SL]]|0.452|
|[[:human genes:n:ndufs3|NDUFS3]]|0.447|
|[[:human genes:n:ndufa8|NDUFA8]]|0.445|
|[[:human genes:y:yars2|YARS2]]|0.444|
|[[:human genes:t:trub2|TRUB2]]|0.441|
|[[:human genes:c:coq7|COQ7]]|0.44|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.439|
|[[:human genes:m:mrpl21|MRPL21]]|0.439|
|[[:human genes:m:mrps6|MRPS6]]|0.437|
|[[:human genes:g:glrx5|GLRX5]]|0.435|
|[[:human genes:m:mtg1|MTG1]]|0.433|
|[[:human genes:m:mrps25|MRPS25]]|0.433|
|[[:human genes:f:foxred1|FOXRED1]]|0.431|
|[[:human genes:m:mrpl23|MRPL23]]|0.428|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.425|
|[[:human genes:w:wars2|WARS2]]|0.422|
|[[:human genes:i:ict1|ICT1]]|0.421|
|[[:human genes:n:ndufb3|NDUFB3]]|0.421|
|[[:human genes:m:mettl17|METTL17]]|0.419|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.418|
|[[:human genes:m:mrpl47|MRPL47]]|0.414|
|[[:human genes:n:ndufv2|NDUFV2]]|0.414|
|[[:human genes:m:mrpl1|MRPL1]]|0.413|
|[[:human genes:m:mcat|MCAT]]|0.411|
|[[:human genes:r:rpusd3|RPUSD3]]|0.411|
|[[:human genes:m:mrps21|MRPS21]]|0.41|
|[[:human genes:n:ndufv1|NDUFV1]]|0.41|
|[[:human genes:c:clpp|CLPP]]|0.41|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.408|
|[[:human genes:w:wbscr16|WBSCR16]]|0.407|
|[[:human genes:t:timm21|TIMM21]]|0.405|
|[[:human genes:e:eral1|ERAL1]]|0.404|
|[[:human genes:n:ndufa5|NDUFA5]]|0.403|
|[[:human genes:m:mtg2|MTG2]]|0.401|
|[[:human genes:n:ndufb2|NDUFB2]]|0.401|
|[[:human genes:m:mrpl43|MRPL43]]|0.4|
|[[:human genes:s:sfxn4|SFXN4]]|0.4|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|1/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1515
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFAF1 Expression in NALM6 Cells: 4.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>