NDUFAF5 [The Human Chemical-Genetic Interaction Map Project]

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======= NDUFAF5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFAF5
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase complex assembly factor 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79133|79133]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5TEU4|Q5TEU4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFAF5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFAF5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612360|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits. The complex is located in the inner mitochondrial membrane. This gene encodes a mitochondrial protein that is associated with the matrix face of the mitochondrial inner membrane and is required for complex I assembly. A mutation in this gene results in mitochondrial complex I deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Arginine hydroxylase involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages (PubMed:18940309, PubMed:27226634). Acts by mediating hydroxylation of 'Arg-111' of NDUFS7 (PubMed:27226634). May also have methyltransferase activity (Probable). {ECO:0000269|PubMed:18940309, ECO:0000269|PubMed:27226634, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Methyltransf 12|
|Ubie methyltran|
|Methyltransf 11|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peptidyl-arginine hydroxylation|
|extrinsic component of mitochondrial inner membrane|
|peptidyl-arginine modification|
|methyltransferase activity|
|NADH dehydrogenase complex assembly|
|mitochondrial respiratory chain complex I assembly|
|mitochondrial respiratory chain complex assembly|
|oxidoreductase activity|
|methylation|
|mitochondrial inner membrane|
|mitochondrion organization|
|molecular function|
|cellular protein-containing complex assembly|
|peptidyl-amino acid modification|
|oxidation-reduction process|
|mitochondrion|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.7|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|1.73|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.74|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.75|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.87|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.9|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.91|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.95|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.95|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.96|
|[[:results:exp534|Trientine 500μM R08 exp534]]|2.1|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.12|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.13|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.23|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.26|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.27|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.29|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.32|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|2.38|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.85|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|3.62|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufa1|NDUFA1]]|0.607|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.595|
|[[:human genes:r:rpusd3|RPUSD3]]|0.587|
|[[:human genes:n:ndufb7|NDUFB7]]|0.581|
|[[:human genes:n:ndufs2|NDUFS2]]|0.576|
|[[:human genes:n:nubpl|NUBPL]]|0.567|
|[[:human genes:l:lars2|LARS2]]|0.563|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.562|
|[[:human genes:f:fastkd2|FASTKD2]]|0.554|
|[[:human genes:n:ndufc2|NDUFC2]]|0.553|
|[[:human genes:a:acad9|ACAD9]]|0.552|
|[[:human genes:n:ndufb11|NDUFB11]]|0.55|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.545|
|[[:human genes:g:grsf1|GRSF1]]|0.544|
|[[:human genes:m:mto1|MTO1]]|0.543|
|[[:human genes:n:ndufs5|NDUFS5]]|0.543|
|[[:human genes:n:ndufa11|NDUFA11]]|0.54|
|[[:human genes:g:gfm2|GFM2]]|0.535|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.535|
|[[:human genes:n:ndufv1|NDUFV1]]|0.529|
|[[:human genes:f:ftsj2|FTSJ2]]|0.52|
|[[:human genes:m:mtif2|MTIF2]]|0.52|
|[[:human genes:f:foxred1|FOXRED1]]|0.519|
|[[:human genes:i:iba57|IBA57]]|0.515|
|[[:human genes:n:ndufb9|NDUFB9]]|0.51|
|[[:human genes:e:eral1|ERAL1]]|0.509|
|[[:human genes:n:ndufs8|NDUFS8]]|0.508|
|[[:human genes:n:ndufc1|NDUFC1]]|0.499|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.499|
|[[:human genes:n:ndufa3|NDUFA3]]|0.497|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.496|
|[[:human genes:m:mrps27|MRPS27]]|0.495|
|[[:human genes:n:ndufb6|NDUFB6]]|0.493|
|[[:human genes:n:nsun4|NSUN4]]|0.49|
|[[:human genes:n:ndufa2|NDUFA2]]|0.489|
|[[:human genes:s:ssbp1|SSBP1]]|0.486|
|[[:human genes:m:mrps26|MRPS26]]|0.484|
|[[:human genes:n:ndufs3|NDUFS3]]|0.48|
|[[:human genes:a:aars2|AARS2]]|0.48|
|[[:human genes:m:malsu1|MALSU1]]|0.479|
|[[:human genes:e:ecsit|ECSIT]]|0.479|
|[[:human genes:c:c12orf65|C12orf65]]|0.478|
|[[:human genes:n:nars2|NARS2]]|0.474|
|[[:human genes:s:slc25a51|SLC25A51]]|0.474|
|[[:human genes:p:pet112|PET112]]|0.473|
|[[:human genes:m:mcat|MCAT]]|0.471|
|[[:human genes:n:ndufb5|NDUFB5]]|0.471|
|[[:human genes:p:polg2|POLG2]]|0.47|
|[[:human genes:p:prepl|PREPL]]|0.469|
|[[:human genes:r:rpusd4|RPUSD4]]|0.467|
|[[:human genes:m:mrps21|MRPS21]]|0.466|
|[[:human genes:c:cars2|CARS2]]|0.466|
|[[:human genes:c:coq7|COQ7]]|0.461|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.461|
|[[:human genes:g:glrx5|GLRX5]]|0.458|
|[[:human genes:q:qrsl1|QRSL1]]|0.456|
|[[:human genes:g:gfm1|GFM1]]|0.453|
|[[:human genes:c:chchd1|CHCHD1]]|0.449|
|[[:human genes:y:yars2|YARS2]]|0.449|
|[[:human genes:m:mrpl23|MRPL23]]|0.448|
|[[:human genes:m:mtg1|MTG1]]|0.448|
|[[:human genes:m:mterfd1|MTERFD1]]|0.448|
|[[:human genes:d:dap3|DAP3]]|0.447|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.447|
|[[:human genes:n:ndufa8|NDUFA8]]|0.446|
|[[:human genes:n:ndufv2|NDUFV2]]|0.445|
|[[:human genes:m:mrpl21|MRPL21]]|0.443|
|[[:human genes:m:mrp63|MRP63]]|0.443|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.442|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.441|
|[[:human genes:m:mrpl22|MRPL22]]|0.44|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.439|
|[[:human genes:p:polrmt|POLRMT]]|0.438|
|[[:human genes:s:sfxn4|SFXN4]]|0.436|
|[[:human genes:m:mettl17|METTL17]]|0.433|
|[[:human genes:n:ndufs7|NDUFS7]]|0.432|
|[[:human genes:m:mrps25|MRPS25]]|0.432|
|[[:human genes:n:nfu1|NFU1]]|0.432|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.431|
|[[:human genes:n:ndufb10|NDUFB10]]|0.431|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.43|
|[[:human genes:t:trub2|TRUB2]]|0.429|
|[[:human genes:n:ndufa10|NDUFA10]]|0.429|
|[[:human genes:a:atp5sl|ATP5SL]]|0.428|
|[[:human genes:c:c1qbp|C1QBP]]|0.428|
|[[:human genes:p:pet117|PET117]]|0.426|
|[[:human genes:s:selrc1|SELRC1]]|0.426|
|[[:human genes:n:ndufb4|NDUFB4]]|0.424|
|[[:human genes:m:mrps5|MRPS5]]|0.423|
|[[:human genes:t:tsfm|TSFM]]|0.423|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.422|
|[[:human genes:t:tfb1m|TFB1M]]|0.422|
|[[:human genes:m:mrpl12|MRPL12]]|0.42|
|[[:human genes:m:mrps22|MRPS22]]|0.42|
|[[:human genes:d:dars2|DARS2]]|0.418|
|[[:human genes:m:mrpl45|MRPL45]]|0.418|
|[[:human genes:m:mrps34|MRPS34]]|0.417|
|[[:human genes:c:coa3|COA3]]|0.416|
|[[:human genes:m:mrpl49|MRPL49]]|0.415|
|[[:human genes:n:ndufa6|NDUFA6]]|0.415|
|[[:human genes:m:mrps35|MRPS35]]|0.414|
|[[:human genes:w:wars2|WARS2]]|0.409|
|[[:human genes:s:slc25a52|SLC25A52]]|0.408|
|[[:human genes:p:pde12|PDE12]]|0.408|
|[[:human genes:n:noa1|NOA1]]|0.407|
|[[:human genes:t:tmem261|TMEM261]]|0.407|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.407|
|[[:human genes:m:mars2|MARS2]]|0.407|
|[[:human genes:r:rars2|RARS2]]|0.406|
|[[:human genes:p:pars2|PARS2]]|0.406|
|[[:human genes:t:trit1|TRIT1]]|0.404|
|[[:human genes:v:vars2|VARS2]]|0.403|
|[[:human genes:n:ndufb2|NDUFB2]]|0.402|
|[[:human genes:n:ndufs1|NDUFS1]]|0.402|
|[[:human genes:n:ndufb3|NDUFB3]]|0.401|
|[[:human genes:f:fars2|FARS2]]|0.401|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1388
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFAF5 Expression in NALM6 Cells: 5.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>