NDUFB11 [The Human Chemical-Genetic Interaction Map Project]

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======= NDUFB11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFB11
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase subunit B11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54539|54539]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NX14|Q9NX14]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFB11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFB11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300403|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is located at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to ubiquinone. Mutations in the human gene are associated with linear skin defects with multiple congenital anomalies 3 and mitochondrial complex I deficiency. [provided by RefSeq, Dec 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ESSS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial electron transport, NADH to ubiquinone|
|mitochondrial respiratory chain complex I|
|NADH dehydrogenase complex assembly|
|mitochondrial respiratory chain complex I assembly|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|respiratory electron transport chain|
|oxidative phosphorylation|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|oxidation-reduction process|
|mitochondrion|
|phosphorylation|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp133|MKC9989 10μM R03 exp133]]|-1.72|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|1.74|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.74|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.75|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|1.77|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.79|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.82|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|1.82|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.82|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.83|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.83|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.84|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.85|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.86|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.9|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.9|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.92|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.93|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.99|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.02|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.11|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.22|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.27|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.4|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.42|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.53|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.54|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.58|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.6|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.62|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.62|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.69|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|2.74|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.88|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|3.11|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|3.15|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|3.43|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|3.81|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufa1|NDUFA1]]|0.741|
|[[:human genes:n:ndufb9|NDUFB9]]|0.736|
|[[:human genes:n:ndufs2|NDUFS2]]|0.733|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.727|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.724|
|[[:human genes:n:ndufa2|NDUFA2]]|0.72|
|[[:human genes:n:ndufa3|NDUFA3]]|0.719|
|[[:human genes:g:grsf1|GRSF1]]|0.706|
|[[:human genes:n:ndufb6|NDUFB6]]|0.689|
|[[:human genes:a:acad9|ACAD9]]|0.687|
|[[:human genes:n:ndufa11|NDUFA11]]|0.671|
|[[:human genes:m:mrps21|MRPS21]]|0.67|
|[[:human genes:e:ecsit|ECSIT]]|0.668|
|[[:human genes:t:tars2|TARS2]]|0.665|
|[[:human genes:n:nubpl|NUBPL]]|0.661|
|[[:human genes:f:ftsj2|FTSJ2]]|0.65|
|[[:human genes:m:mto1|MTO1]]|0.645|
|[[:human genes:n:ndufc2|NDUFC2]]|0.642|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.641|
|[[:human genes:y:yars2|YARS2]]|0.64|
|[[:human genes:q:qrsl1|QRSL1]]|0.638|
|[[:human genes:n:ndufc1|NDUFC1]]|0.633|
|[[:human genes:d:dap3|DAP3]]|0.633|
|[[:human genes:n:nars2|NARS2]]|0.63|
|[[:human genes:g:gfm1|GFM1]]|0.627|
|[[:human genes:m:mrpl21|MRPL21]]|0.625|
|[[:human genes:n:ndufb5|NDUFB5]]|0.625|
|[[:human genes:n:ndufs7|NDUFS7]]|0.624|
|[[:human genes:n:ndufa8|NDUFA8]]|0.624|
|[[:human genes:n:ndufs5|NDUFS5]]|0.619|
|[[:human genes:l:lars2|LARS2]]|0.618|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.618|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.617|
|[[:human genes:p:pars2|PARS2]]|0.616|
|[[:human genes:g:gfm2|GFM2]]|0.613|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.609|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.607|
|[[:human genes:a:atp5sl|ATP5SL]]|0.607|
|[[:human genes:n:ndufv1|NDUFV1]]|0.605|
|[[:human genes:m:mrps5|MRPS5]]|0.604|
|[[:human genes:c:c12orf65|C12orf65]]|0.601|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.599|
|[[:human genes:m:mrps25|MRPS25]]|0.599|
|[[:human genes:m:mrpl23|MRPL23]]|0.597|
|[[:human genes:e:ears2|EARS2]]|0.597|
|[[:human genes:c:c17orf89|C17orf89]]|0.592|
|[[:human genes:n:ndufb7|NDUFB7]]|0.59|
|[[:human genes:p:pet117|PET117]]|0.589|
|[[:human genes:n:ndufa10|NDUFA10]]|0.589|
|[[:human genes:m:mrps34|MRPS34]]|0.588|
|[[:human genes:r:rbfa|RBFA]]|0.586|
|[[:human genes:s:selrc1|SELRC1]]|0.586|
|[[:human genes:m:mrp63|MRP63]]|0.585|
|[[:human genes:r:rpusd3|RPUSD3]]|0.584|
|[[:human genes:c:chchd1|CHCHD1]]|0.583|
|[[:human genes:d:dars2|DARS2]]|0.582|
|[[:human genes:t:tefm|TEFM]]|0.582|
|[[:human genes:m:mrps6|MRPS6]]|0.581|
|[[:human genes:p:polg|POLG]]|0.58|
|[[:human genes:n:nfu1|NFU1]]|0.58|
|[[:human genes:p:polg2|POLG2]]|0.579|
|[[:human genes:p:pet112|PET112]]|0.579|
|[[:human genes:i:iba57|IBA57]]|0.578|
|[[:human genes:w:wbscr16|WBSCR16]]|0.578|
|[[:human genes:g:gatc|GATC]]|0.578|
|[[:human genes:m:mrpl47|MRPL47]]|0.577|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.577|
|[[:human genes:m:mettl17|METTL17]]|0.576|
|[[:human genes:n:ndufb2|NDUFB2]]|0.576|
|[[:human genes:r:rpusd4|RPUSD4]]|0.575|
|[[:human genes:m:mrps14|MRPS14]]|0.574|
|[[:human genes:m:mrps16|MRPS16]]|0.574|
|[[:human genes:t:tmem261|TMEM261]]|0.574|
|[[:human genes:c:c10orf2|C10orf2]]|0.572|
|[[:human genes:m:mtg1|MTG1]]|0.572|
|[[:human genes:v:vars2|VARS2]]|0.572|
|[[:human genes:b:bcs1l|BCS1L]]|0.571|
|[[:human genes:m:mrpl53|MRPL53]]|0.57|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.569|
|[[:human genes:n:ndufa6|NDUFA6]]|0.569|
|[[:human genes:n:ndufs8|NDUFS8]]|0.561|
|[[:human genes:m:mrpl15|MRPL15]]|0.559|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.559|
|[[:human genes:n:ndufb10|NDUFB10]]|0.559|
|[[:human genes:t:tufm|TUFM]]|0.556|
|[[:human genes:m:mrps33|MRPS33]]|0.555|
|[[:human genes:m:mrpl45|MRPL45]]|0.553|
|[[:human genes:n:ndufv2|NDUFV2]]|0.553|
|[[:human genes:n:ndufs3|NDUFS3]]|0.553|
|[[:human genes:s:sco2|SCO2]]|0.552|
|[[:human genes:m:mars2|MARS2]]|0.552|
|[[:human genes:f:foxred1|FOXRED1]]|0.551|
|[[:human genes:f:fastkd2|FASTKD2]]|0.55|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.55|
|[[:human genes:p:polrmt|POLRMT]]|0.55|
|[[:human genes:m:mtg2|MTG2]]|0.546|
|[[:human genes:m:mrpl12|MRPL12]]|0.545|
|[[:human genes:m:mrps27|MRPS27]]|0.545|
|[[:human genes:c:coq7|COQ7]]|0.544|
|[[:human genes:c:coa3|COA3]]|0.544|
|[[:human genes:s:sars2|SARS2]]|0.541|
|[[:human genes:m:mipep|MIPEP]]|0.537|
|[[:human genes:m:mrps26|MRPS26]]|0.537|
|[[:human genes:m:mrpl3|MRPL3]]|0.536|
|[[:human genes:m:malsu1|MALSU1]]|0.533|
|[[:human genes:a:aars2|AARS2]]|0.532|
|[[:human genes:n:ndufb4|NDUFB4]]|0.532|
|[[:human genes:s:ssbp1|SSBP1]]|0.532|
|[[:human genes:m:mrpl44|MRPL44]]|0.531|
|[[:human genes:n:ndufs1|NDUFS1]]|0.531|
|[[:human genes:t:tfb1m|TFB1M]]|0.531|
|[[:human genes:c:coq2|COQ2]]|0.528|
|[[:human genes:m:mrps9|MRPS9]]|0.526|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.525|
|[[:human genes:m:mrps18a|MRPS18A]]|0.525|
|[[:human genes:n:ndufa13|NDUFA13]]|0.525|
|[[:human genes:m:mcat|MCAT]]|0.524|
|[[:human genes:g:glrx5|GLRX5]]|0.524|
|[[:human genes:r:rars2|RARS2]]|0.519|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.518|
|[[:human genes:m:mrps2|MRPS2]]|0.517|
|[[:human genes:m:mrps12|MRPS12]]|0.517|
|[[:human genes:t:trub2|TRUB2]]|0.516|
|[[:human genes:t:tomm20|TOMM20]]|0.515|
|[[:human genes:w:wars2|WARS2]]|0.514|
|[[:human genes:m:mrpl17|MRPL17]]|0.513|
|[[:human genes:p:pnpt1|PNPT1]]|0.513|
|[[:human genes:d:ddx28|DDX28]]|0.512|
|[[:human genes:s:slc25a26|SLC25A26]]|0.512|
|[[:human genes:h:hars2|HARS2]]|0.512|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.51|
|[[:human genes:a:aifm1|AIFM1]]|0.51|
|[[:human genes:c:c1qbp|C1QBP]]|0.509|
|[[:human genes:m:mrpl43|MRPL43]]|0.508|
|[[:human genes:m:mrps24|MRPS24]]|0.508|
|[[:human genes:f:fars2|FARS2]]|0.508|
|[[:human genes:m:mrpl55|MRPL55]]|0.508|
|[[:human genes:f:fastkd5|FASTKD5]]|0.508|
|[[:human genes:c:cars2|CARS2]]|0.507|
|[[:human genes:m:mrps10|MRPS10]]|0.507|
|[[:human genes:m:mrpl13|MRPL13]]|0.506|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.505|
|[[:human genes:m:mterfd1|MTERFD1]]|0.504|
|[[:human genes:m:mrpl22|MRPL22]]|0.499|
|[[:human genes:c:cox16|COX16]]|0.494|
|[[:human genes:m:mrps17|MRPS17]]|0.494|
|[[:human genes:m:mtif2|MTIF2]]|0.493|
|[[:human genes:c:cox7b|COX7B]]|0.491|
|[[:human genes:n:ndufa5|NDUFA5]]|0.491|
|[[:human genes:c:cox15|COX15]]|0.489|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.489|
|[[:human genes:p:ptcd3|PTCD3]]|0.488|
|[[:human genes:c:cox11|COX11]]|0.488|
|[[:human genes:p:pdss1|PDSS1]]|0.485|
|[[:human genes:m:mrps11|MRPS11]]|0.48|
|[[:human genes:n:ndufb3|NDUFB3]]|0.48|
|[[:human genes:m:mrpl2|MRPL2]]|0.479|
|[[:human genes:s:slc25a3|SLC25A3]]|0.478|
|[[:human genes:m:mrps23|MRPS23]]|0.477|
|[[:human genes:m:mrpl42|MRPL42]]|0.476|
|[[:human genes:t:tfam|TFAM]]|0.475|
|[[:human genes:m:mrpl11|MRPL11]]|0.475|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.472|
|[[:human genes:s:slc25a19|SLC25A19]]|0.471|
|[[:human genes:c:coa6|COA6]]|0.471|
|[[:human genes:e:eral1|ERAL1]]|0.47|
|[[:human genes:a:atp5c1|ATP5C1]]|0.47|
|[[:human genes:c:coq3|COQ3]]|0.469|
|[[:human genes:n:ndufa9|NDUFA9]]|0.469|
|[[:human genes:m:mterfd2|MTERFD2]]|0.468|
|[[:human genes:m:mrpl41|MRPL41]]|0.468|
|[[:human genes:m:mrpl20|MRPL20]]|0.467|
|[[:human genes:s:slc25a51|SLC25A51]]|0.466|
|[[:human genes:c:cox17|COX17]]|0.459|
|[[:human genes:a:atp5d|ATP5D]]|0.459|
|[[:human genes:t:tpk1|TPK1]]|0.458|
|[[:human genes:s:slc25a52|SLC25A52]]|0.457|
|[[:human genes:n:ndufb1|NDUFB1]]|0.457|
|[[:human genes:m:mrps35|MRPS35]]|0.455|
|[[:human genes:n:nsun4|NSUN4]]|0.453|
|[[:human genes:m:mrpl4|MRPL4]]|0.452|
|[[:human genes:t:tmem242|TMEM242]]|0.452|
|[[:human genes:t:trmt10c|TRMT10C]]|0.449|
|[[:human genes:t:tomm6|TOMM6]]|0.448|
|[[:human genes:m:mrpl28|MRPL28]]|0.447|
|[[:human genes:m:mtpap|MTPAP]]|0.447|
|[[:human genes:m:mrpl18|MRPL18]]|0.446|
|[[:human genes:m:mrpl46|MRPL46]]|0.445|
|[[:human genes:m:mrpl34|MRPL34]]|0.445|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.443|
|[[:human genes:u:uqcr10|UQCR10]]|0.443|
|[[:human genes:m:mrps7|MRPS7]]|0.443|
|[[:human genes:n:noa1|NOA1]]|0.442|
|[[:human genes:t:timm21|TIMM21]]|0.441|
|[[:human genes:f:fastkd1|FASTKD1]]|0.438|
|[[:human genes:e:elac2|ELAC2]]|0.437|
|[[:human genes:a:alas1|ALAS1]]|0.435|
|[[:human genes:m:mrps22|MRPS22]]|0.434|
|[[:human genes:f:fh|FH]]|0.433|
|[[:human genes:c:cox5a|COX5A]]|0.43|
|[[:human genes:c:cox6c|COX6C]]|0.43|
|[[:human genes:i:ict1|ICT1]]|0.428|
|[[:human genes:i:isca2|ISCA2]]|0.428|
|[[:human genes:t:tmem126b|TMEM126B]]|0.428|
|[[:human genes:m:mrpl1|MRPL1]]|0.427|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.425|
|[[:human genes:u:uqcrc1|UQCRC1]]|0.424|
|[[:human genes:a:atp5a1|ATP5A1]]|0.422|
|[[:human genes:m:mrps18b|MRPS18B]]|0.421|
|[[:human genes:m:mtif3|MTIF3]]|0.419|
|[[:human genes:m:mrpl49|MRPL49]]|0.417|
|[[:human genes:p:pitrm1|PITRM1]]|0.416|
|[[:human genes:l:lrpprc|LRPPRC]]|0.415|
|[[:human genes:c:clpp|CLPP]]|0.415|
|[[:human genes:p:pdss2|PDSS2]]|0.415|
|[[:human genes:m:mrpl39|MRPL39]]|0.414|
|[[:human genes:p:pde12|PDE12]]|0.414|
|[[:human genes:m:minos1|MINOS1]]|0.412|
|[[:human genes:a:atp5e|ATP5E]]|0.411|
|[[:human genes:t:timm8b|TIMM8B]]|0.411|
|[[:human genes:n:ndufb8|NDUFB8]]|0.411|
|[[:human genes:r:rpia|RPIA]]|0.41|
|[[:human genes:m:mrpl33|MRPL33]]|0.409|
|[[:human genes:s:sfxn4|SFXN4]]|0.405|
|[[:human genes:r:rmnd1|RMND1]]|0.405|
|[[:human genes:d:dhx30|DHX30]]|0.402|
|[[:human genes:c:cox6b1|COX6B1]]|0.401|
|[[:human genes:p:ptcd1|PTCD1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 24/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|0/26|
|bone|0/26|
|breast|2/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|1/14|
|kidney|2/18|
|liver|1/19|
|lung|4/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|2/20|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|2/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 759
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFB11 Expression in NALM6 Cells: 5.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>