NDUFB5 [The Human Chemical-Genetic Interaction Map Project]

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======= NDUFB5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFB5
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase subunit B5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4711|4711]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43674|O43674]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFB5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFB5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603841|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NDUF B5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NADH dehydrogenase (ubiquinone) activity|
|mitochondrial electron transport, NADH to ubiquinone|
|mitochondrial respiratory chain complex I|
|mitochondrial respiratory chain complex I assembly|
|NADH dehydrogenase complex assembly|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|respiratory electron transport chain|
|oxidative phosphorylation|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|oxidation-reduction process|
|mitochondrion|
|phosphorylation|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|-1.92|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.79|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.72|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|1.73|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.83|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.83|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.85|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.97|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.99|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.04|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.11|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.18|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.48|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|3.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufa1|NDUFA1]]|0.65|
|[[:human genes:n:ndufa3|NDUFA3]]|0.647|
|[[:human genes:c:c17orf89|C17orf89]]|0.644|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.638|
|[[:human genes:n:ndufb11|NDUFB11]]|0.625|
|[[:human genes:e:ecsit|ECSIT]]|0.622|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.619|
|[[:human genes:n:ndufc2|NDUFC2]]|0.618|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.616|
|[[:human genes:c:c12orf65|C12orf65]]|0.612|
|[[:human genes:n:ndufb6|NDUFB6]]|0.601|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.601|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.6|
|[[:human genes:n:ndufa10|NDUFA10]]|0.598|
|[[:human genes:n:ndufa2|NDUFA2]]|0.593|
|[[:human genes:n:ndufa11|NDUFA11]]|0.59|
|[[:human genes:g:gfm1|GFM1]]|0.578|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.577|
|[[:human genes:g:grsf1|GRSF1]]|0.562|
|[[:human genes:n:ndufb9|NDUFB9]]|0.562|
|[[:human genes:m:mrpl21|MRPL21]]|0.562|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.56|
|[[:human genes:y:yars2|YARS2]]|0.554|
|[[:human genes:n:ndufs2|NDUFS2]]|0.553|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.553|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.551|
|[[:human genes:a:acad9|ACAD9]]|0.546|
|[[:human genes:n:ndufs7|NDUFS7]]|0.546|
|[[:human genes:g:gfm2|GFM2]]|0.544|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.541|
|[[:human genes:t:tars2|TARS2]]|0.541|
|[[:human genes:m:mrps5|MRPS5]]|0.54|
|[[:human genes:r:rbfa|RBFA]]|0.535|
|[[:human genes:n:ndufa8|NDUFA8]]|0.534|
|[[:human genes:b:bcs1l|BCS1L]]|0.531|
|[[:human genes:m:mrps34|MRPS34]]|0.53|
|[[:human genes:r:rpusd3|RPUSD3]]|0.529|
|[[:human genes:f:foxred1|FOXRED1]]|0.527|
|[[:human genes:t:tmem242|TMEM242]]|0.525|
|[[:human genes:m:mrps16|MRPS16]]|0.522|
|[[:human genes:p:polg2|POLG2]]|0.521|
|[[:human genes:m:mrps21|MRPS21]]|0.52|
|[[:human genes:c:cox16|COX16]]|0.519|
|[[:human genes:m:mrps33|MRPS33]]|0.519|
|[[:human genes:n:ndufb3|NDUFB3]]|0.518|
|[[:human genes:g:gatc|GATC]]|0.518|
|[[:human genes:m:mrpl45|MRPL45]]|0.517|
|[[:human genes:n:nfu1|NFU1]]|0.517|
|[[:human genes:q:qrsl1|QRSL1]]|0.515|
|[[:human genes:p:polg|POLG]]|0.515|
|[[:human genes:c:coq7|COQ7]]|0.515|
|[[:human genes:m:mrpl23|MRPL23]]|0.514|
|[[:human genes:s:selrc1|SELRC1]]|0.514|
|[[:human genes:l:lars2|LARS2]]|0.513|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.513|
|[[:human genes:m:mrps14|MRPS14]]|0.509|
|[[:human genes:n:nubpl|NUBPL]]|0.508|
|[[:human genes:w:wbscr16|WBSCR16]]|0.508|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.506|
|[[:human genes:m:mto1|MTO1]]|0.506|
|[[:human genes:p:pdss1|PDSS1]]|0.505|
|[[:human genes:m:mrps6|MRPS6]]|0.505|
|[[:human genes:t:tmem261|TMEM261]]|0.504|
|[[:human genes:a:atp5sl|ATP5SL]]|0.504|
|[[:human genes:n:ndufs8|NDUFS8]]|0.503|
|[[:human genes:s:sco2|SCO2]]|0.5|
|[[:human genes:s:slc25a26|SLC25A26]]|0.499|
|[[:human genes:e:ears2|EARS2]]|0.499|
|[[:human genes:c:c10orf2|C10orf2]]|0.498|
|[[:human genes:s:sars2|SARS2]]|0.497|
|[[:human genes:n:nars2|NARS2]]|0.496|
|[[:human genes:n:ndufa6|NDUFA6]]|0.494|
|[[:human genes:m:mrpl15|MRPL15]]|0.493|
|[[:human genes:m:mrpl53|MRPL53]]|0.492|
|[[:human genes:r:rpusd4|RPUSD4]]|0.49|
|[[:human genes:d:dars2|DARS2]]|0.489|
|[[:human genes:n:ndufb2|NDUFB2]]|0.488|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.487|
|[[:human genes:s:slc25a19|SLC25A19]]|0.486|
|[[:human genes:m:mtg1|MTG1]]|0.484|
|[[:human genes:i:isca2|ISCA2]]|0.48|
|[[:human genes:m:mrps26|MRPS26]]|0.478|
|[[:human genes:i:iba57|IBA57]]|0.478|
|[[:human genes:m:mrp63|MRP63]]|0.476|
|[[:human genes:c:chchd1|CHCHD1]]|0.475|
|[[:human genes:p:pars2|PARS2]]|0.474|
|[[:human genes:a:atp5d|ATP5D]]|0.474|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.471|
|[[:human genes:m:mtg2|MTG2]]|0.47|
|[[:human genes:c:coq2|COQ2]]|0.468|
|[[:human genes:a:atp5c1|ATP5C1]]|0.468|
|[[:human genes:m:mrpl12|MRPL12]]|0.467|
|[[:human genes:a:aifm1|AIFM1]]|0.463|
|[[:human genes:h:hars2|HARS2]]|0.463|
|[[:human genes:f:ftsj2|FTSJ2]]|0.462|
|[[:human genes:n:ndufc1|NDUFC1]]|0.462|
|[[:human genes:t:tefm|TEFM]]|0.461|
|[[:human genes:n:ndufv1|NDUFV1]]|0.461|
|[[:human genes:t:tufm|TUFM]]|0.461|
|[[:human genes:n:ndufs1|NDUFS1]]|0.461|
|[[:human genes:m:mrps11|MRPS11]]|0.46|
|[[:human genes:m:mrpl47|MRPL47]]|0.457|
|[[:human genes:v:vars2|VARS2]]|0.454|
|[[:human genes:d:dap3|DAP3]]|0.454|
|[[:human genes:n:ndufa5|NDUFA5]]|0.453|
|[[:human genes:m:mipep|MIPEP]]|0.451|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.45|
|[[:human genes:f:fastkd5|FASTKD5]]|0.448|
|[[:human genes:n:ndufb10|NDUFB10]]|0.447|
|[[:human genes:c:cox5a|COX5A]]|0.447|
|[[:human genes:n:ndufb7|NDUFB7]]|0.447|
|[[:human genes:f:fastkd2|FASTKD2]]|0.446|
|[[:human genes:g:glrx5|GLRX5]]|0.446|
|[[:human genes:n:ndufs5|NDUFS5]]|0.441|
|[[:human genes:t:tmem126b|TMEM126B]]|0.441|
|[[:human genes:c:chchd4|CHCHD4]]|0.44|
|[[:human genes:m:mrps18a|MRPS18A]]|0.44|
|[[:human genes:c:cars2|CARS2]]|0.439|
|[[:human genes:m:mrpl43|MRPL43]]|0.438|
|[[:human genes:m:mcat|MCAT]]|0.437|
|[[:human genes:m:mrpl27|MRPL27]]|0.436|
|[[:human genes:p:pnpt1|PNPT1]]|0.436|
|[[:human genes:a:atp5a1|ATP5A1]]|0.435|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.435|
|[[:human genes:m:mrpl20|MRPL20]]|0.434|
|[[:human genes:n:ndufb4|NDUFB4]]|0.432|
|[[:human genes:f:fh|FH]]|0.43|
|[[:human genes:m:mrps9|MRPS9]]|0.429|
|[[:human genes:m:mrps2|MRPS2]]|0.427|
|[[:human genes:m:mrpl44|MRPL44]]|0.425|
|[[:human genes:f:fars2|FARS2]]|0.423|
|[[:human genes:t:tpk1|TPK1]]|0.423|
|[[:human genes:n:ndufs3|NDUFS3]]|0.422|
|[[:human genes:a:atp5e|ATP5E]]|0.421|
|[[:human genes:c:cox6c|COX6C]]|0.421|
|[[:human genes:m:mrps25|MRPS25]]|0.42|
|[[:human genes:a:aars2|AARS2]]|0.419|
|[[:human genes:w:wars2|WARS2]]|0.419|
|[[:human genes:a:atp5h|ATP5H]]|0.419|
|[[:human genes:c:cox7b|COX7B]]|0.418|
|[[:human genes:d:dhx30|DHX30]]|0.417|
|[[:human genes:n:ndufb1|NDUFB1]]|0.416|
|[[:human genes:r:rars2|RARS2]]|0.416|
|[[:human genes:c:coa6|COA6]]|0.416|
|[[:human genes:m:mrpl22|MRPL22]]|0.415|
|[[:human genes:a:atp5b|ATP5B]]|0.415|
|[[:human genes:s:slc25a3|SLC25A3]]|0.413|
|[[:human genes:n:ndufb8|NDUFB8]]|0.413|
|[[:human genes:p:pet112|PET112]]|0.412|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.412|
|[[:human genes:a:atxn10|ATXN10]]|0.411|
|[[:human genes:t:timm8b|TIMM8B]]|0.411|
|[[:human genes:t:timm21|TIMM21]]|0.41|
|[[:human genes:m:mrps23|MRPS23]]|0.407|
|[[:human genes:c:coq4|COQ4]]|0.407|
|[[:human genes:t:triap1|TRIAP1]]|0.406|
|[[:human genes:p:polrmt|POLRMT]]|0.405|
|[[:human genes:m:mrps10|MRPS10]]|0.404|
|[[:human genes:t:trub2|TRUB2]]|0.403|
|[[:human genes:s:slc25a52|SLC25A52]]|0.403|
|[[:human genes:r:rpia|RPIA]]|0.401|
|[[:human genes:m:mtpap|MTPAP]]|0.401|
|[[:human genes:m:mrpl36|MRPL36]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3513
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFB5 Expression in NALM6 Cells: 5.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>