NDUFB6 [The Human Chemical-Genetic Interaction Map Project]

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======= NDUFB6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFB6
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase subunit B6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4712|4712]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95139|O95139]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFB6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFB6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603322|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jan 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NDUF B6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NADH dehydrogenase (ubiquinone) activity|
|mitochondrial electron transport, NADH to ubiquinone|
|mitochondrial respiratory chain complex I|
|NADH dehydrogenase complex assembly|
|mitochondrial respiratory chain complex I assembly|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|mitochondrial membrane|
|respiratory electron transport chain|
|oxidative phosphorylation|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|oxidation-reduction process|
|mitochondrion|
|phosphorylation|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp495|IWR1 50μM R08 exp495]]|-1.89|
|[[:results:exp303|39°C R06 exp303]]|-1.88|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.7|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.7|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.74|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|1.76|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.76|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.76|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.78|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.85|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.02|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|2.36|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.41|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.97|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.03|
|[[:results:exp360|Genistein 15μM R07 exp360]]|3.13|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|3.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufb11|NDUFB11]]|0.689|
|[[:human genes:e:ecsit|ECSIT]]|0.632|
|[[:human genes:n:ndufa3|NDUFA3]]|0.62|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.606|
|[[:human genes:n:ndufa11|NDUFA11]]|0.604|
|[[:human genes:n:ndufa1|NDUFA1]]|0.603|
|[[:human genes:n:ndufb5|NDUFB5]]|0.601|
|[[:human genes:n:ndufs2|NDUFS2]]|0.597|
|[[:human genes:g:grsf1|GRSF1]]|0.592|
|[[:human genes:n:ndufb9|NDUFB9]]|0.588|
|[[:human genes:n:ndufa10|NDUFA10]]|0.585|
|[[:human genes:n:ndufa2|NDUFA2]]|0.585|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.576|
|[[:human genes:r:rpusd3|RPUSD3]]|0.57|
|[[:human genes:a:acad9|ACAD9]]|0.564|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.56|
|[[:human genes:m:mto1|MTO1]]|0.558|
|[[:human genes:f:ftsj2|FTSJ2]]|0.556|
|[[:human genes:m:mrpl21|MRPL21]]|0.546|
|[[:human genes:g:gfm2|GFM2]]|0.542|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.541|
|[[:human genes:n:ndufc2|NDUFC2]]|0.541|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.539|
|[[:human genes:c:c17orf89|C17orf89]]|0.537|
|[[:human genes:n:ndufc1|NDUFC1]]|0.536|
|[[:human genes:n:ndufs7|NDUFS7]]|0.535|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.534|
|[[:human genes:n:ndufa8|NDUFA8]]|0.533|
|[[:human genes:n:nars2|NARS2]]|0.528|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.528|
|[[:human genes:g:gfm1|GFM1]]|0.528|
|[[:human genes:n:nubpl|NUBPL]]|0.526|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.524|
|[[:human genes:m:mrps16|MRPS16]]|0.523|
|[[:human genes:f:fars2|FARS2]]|0.518|
|[[:human genes:t:tars2|TARS2]]|0.518|
|[[:human genes:n:ndufs5|NDUFS5]]|0.518|
|[[:human genes:l:lars2|LARS2]]|0.518|
|[[:human genes:a:atp5sl|ATP5SL]]|0.513|
|[[:human genes:m:mipep|MIPEP]]|0.513|
|[[:human genes:y:yars2|YARS2]]|0.512|
|[[:human genes:w:wbscr16|WBSCR16]]|0.512|
|[[:human genes:m:mrpl45|MRPL45]]|0.512|
|[[:human genes:n:ndufs1|NDUFS1]]|0.51|
|[[:human genes:n:ndufs8|NDUFS8]]|0.509|
|[[:human genes:t:tmem261|TMEM261]]|0.505|
|[[:human genes:m:mrps25|MRPS25]]|0.503|
|[[:human genes:q:qrsl1|QRSL1]]|0.503|
|[[:human genes:n:ndufb2|NDUFB2]]|0.501|
|[[:human genes:m:mrps5|MRPS5]]|0.5|
|[[:human genes:m:mrpl47|MRPL47]]|0.499|
|[[:human genes:m:mrpl23|MRPL23]]|0.499|
|[[:human genes:n:ndufv2|NDUFV2]]|0.497|
|[[:human genes:d:dap3|DAP3]]|0.497|
|[[:human genes:n:ndufb10|NDUFB10]]|0.496|
|[[:human genes:n:ndufa6|NDUFA6]]|0.496|
|[[:human genes:n:ndufb7|NDUFB7]]|0.495|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.494|
|[[:human genes:p:pars2|PARS2]]|0.494|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.493|
|[[:human genes:d:dars2|DARS2]]|0.493|
|[[:human genes:m:mrps21|MRPS21]]|0.492|
|[[:human genes:r:rbfa|RBFA]]|0.491|
|[[:human genes:p:polg|POLG]]|0.491|
|[[:human genes:s:selrc1|SELRC1]]|0.489|
|[[:human genes:g:gatc|GATC]]|0.487|
|[[:human genes:c:chchd1|CHCHD1]]|0.486|
|[[:human genes:m:mrps6|MRPS6]]|0.485|
|[[:human genes:m:mrpl15|MRPL15]]|0.483|
|[[:human genes:s:ssbp1|SSBP1]]|0.482|
|[[:human genes:i:iba57|IBA57]]|0.481|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.481|
|[[:human genes:m:mrps26|MRPS26]]|0.48|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.48|
|[[:human genes:n:nfu1|NFU1]]|0.478|
|[[:human genes:m:mrps33|MRPS33]]|0.478|
|[[:human genes:n:ndufb4|NDUFB4]]|0.478|
|[[:human genes:c:c12orf65|C12orf65]]|0.478|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.477|
|[[:human genes:m:mrp63|MRP63]]|0.477|
|[[:human genes:m:mrps34|MRPS34]]|0.476|
|[[:human genes:f:foxred1|FOXRED1]]|0.475|
|[[:human genes:m:mrpl13|MRPL13]]|0.474|
|[[:human genes:c:cox11|COX11]]|0.473|
|[[:human genes:c:c10orf2|C10orf2]]|0.47|
|[[:human genes:m:malsu1|MALSU1]]|0.47|
|[[:human genes:f:fastkd2|FASTKD2]]|0.47|
|[[:human genes:a:aifm1|AIFM1]]|0.468|
|[[:human genes:a:aars2|AARS2]]|0.467|
|[[:human genes:m:mrps14|MRPS14]]|0.465|
|[[:human genes:n:ndufs3|NDUFS3]]|0.462|
|[[:human genes:n:ndufv1|NDUFV1]]|0.462|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.461|
|[[:human genes:n:ndufb3|NDUFB3]]|0.459|
|[[:human genes:m:mtg1|MTG1]]|0.458|
|[[:human genes:m:mrps11|MRPS11]]|0.455|
|[[:human genes:m:mettl17|METTL17]]|0.455|
|[[:human genes:p:pet117|PET117]]|0.454|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.453|
|[[:human genes:m:mrps12|MRPS12]]|0.452|
|[[:human genes:p:polg2|POLG2]]|0.452|
|[[:human genes:t:tfb1m|TFB1M]]|0.451|
|[[:human genes:n:ndufa5|NDUFA5]]|0.451|
|[[:human genes:s:sco2|SCO2]]|0.45|
|[[:human genes:v:vars2|VARS2]]|0.449|
|[[:human genes:t:tufm|TUFM]]|0.449|
|[[:human genes:e:ears2|EARS2]]|0.447|
|[[:human genes:p:polrmt|POLRMT]]|0.446|
|[[:human genes:c:cars2|CARS2]]|0.445|
|[[:human genes:e:eral1|ERAL1]]|0.445|
|[[:human genes:m:mrps18a|MRPS18A]]|0.443|
|[[:human genes:m:mrpl53|MRPL53]]|0.443|
|[[:human genes:p:pet112|PET112]]|0.443|
|[[:human genes:c:cox16|COX16]]|0.443|
|[[:human genes:n:nsun4|NSUN4]]|0.442|
|[[:human genes:m:mcat|MCAT]]|0.441|
|[[:human genes:m:mtg2|MTG2]]|0.441|
|[[:human genes:r:rpusd4|RPUSD4]]|0.441|
|[[:human genes:t:tomm20|TOMM20]]|0.44|
|[[:human genes:m:mrpl4|MRPL4]]|0.439|
|[[:human genes:m:mrpl3|MRPL3]]|0.438|
|[[:human genes:t:trub2|TRUB2]]|0.437|
|[[:human genes:m:mrpl12|MRPL12]]|0.436|
|[[:human genes:s:slc25a26|SLC25A26]]|0.433|
|[[:human genes:m:mrps17|MRPS17]]|0.432|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.432|
|[[:human genes:m:mars2|MARS2]]|0.43|
|[[:human genes:m:mrps2|MRPS2]]|0.429|
|[[:human genes:e:elac2|ELAC2]]|0.429|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.427|
|[[:human genes:b:bcs1l|BCS1L]]|0.427|
|[[:human genes:g:glrx5|GLRX5]]|0.426|
|[[:human genes:t:tefm|TEFM]]|0.425|
|[[:human genes:c:coq2|COQ2]]|0.425|
|[[:human genes:c:coa3|COA3]]|0.423|
|[[:human genes:p:pdss1|PDSS1]]|0.422|
|[[:human genes:t:tmem242|TMEM242]]|0.422|
|[[:human genes:t:tpk1|TPK1]]|0.422|
|[[:human genes:t:timm21|TIMM21]]|0.42|
|[[:human genes:m:mrpl44|MRPL44]]|0.419|
|[[:human genes:s:slc25a3|SLC25A3]]|0.418|
|[[:human genes:d:ddx28|DDX28]]|0.418|
|[[:human genes:m:mrpl46|MRPL46]]|0.417|
|[[:human genes:c:clpp|CLPP]]|0.415|
|[[:human genes:p:ptcd3|PTCD3]]|0.414|
|[[:human genes:n:noa1|NOA1]]|0.414|
|[[:human genes:m:mterfd1|MTERFD1]]|0.412|
|[[:human genes:m:mrps27|MRPS27]]|0.411|
|[[:human genes:m:mrps22|MRPS22]]|0.411|
|[[:human genes:c:coa6|COA6]]|0.407|
|[[:human genes:c:cox6b1|COX6B1]]|0.407|
|[[:human genes:m:mrpl17|MRPL17]]|0.406|
|[[:human genes:i:ict1|ICT1]]|0.405|
|[[:human genes:m:mrpl2|MRPL2]]|0.405|
|[[:human genes:f:fastkd5|FASTKD5]]|0.403|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.402|
|[[:human genes:r:rars2|RARS2]]|0.402|
|[[:human genes:m:mrps28|MRPS28]]|0.401|
|[[:human genes:f:fh|FH]]|0.401|
|[[:human genes:r:rpia|RPIA]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 105/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|5/28|
|bone|3/26|
|breast|7/33|
|central nervous system|2/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|5/16|
|kidney|3/21|
|liver|7/20|
|lung|13/75|
|lymphocyte|2/16|
|ovary|3/26|
|pancreas|4/24|
|peripheral nervous system|1/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|6/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2137
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFB6 Expression in NALM6 Cells: 5.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>