NDUFB9 [The Human Chemical-Genetic Interaction Map Project]

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======= NDUFB9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFB9
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase subunit B9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4715|4715]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6M9|Q9Y6M9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFB9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFB9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601445|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a subunit of the mitochondrial oxidative phosphorylation complex I (nicotinamide adenine dinucleotide: ubiquinone oxidoreductase). Complex I is localized to the inner mitochondrial membrane and functions to dehydrogenate nicotinamide adenine dinucleotide and to shuttle electrons to coenzyme Q. Complex I deficiency is the most common defect found in oxidative phosphorylation disorders and results in a range of conditions, including lethal neonatal disease, hypertrophic cardiomyopathy, liver disease, and adult-onset neurodegenerative disorders. Pseudogenes of this gene are found on chromosomes five, seven and eight. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NADH dehydrogenase (ubiquinone) activity|
|mitochondrial electron transport, NADH to ubiquinone|
|mitochondrial respiratory chain complex I|
|mitochondrial respiratory chain complex I assembly|
|NADH dehydrogenase complex assembly|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|respiratory electron transport chain|
|oxidative phosphorylation|
|sensory perception of sound|
|sensory perception of mechanical stimulus|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|oxidation-reduction process|
|sensory perception|
|mitochondrion|
|phosphorylation|
|nervous system process|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|-1.84|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|-1.79|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|-1.71|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.7|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.72|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|1.72|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|1.73|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.75|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.76|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.78|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.81|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.86|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.97|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.01|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.01|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.03|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.03|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.2|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.37|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|2.41|
|[[:results:exp534|Trientine 500μM R08 exp534]]|2.41|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.57|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|3.06|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.32|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|3.75|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|4.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufa1|NDUFA1]]|0.753|
|[[:human genes:n:ndufb11|NDUFB11]]|0.736|
|[[:human genes:a:acad9|ACAD9]]|0.708|
|[[:human genes:n:ndufa2|NDUFA2]]|0.677|
|[[:human genes:n:ndufa3|NDUFA3]]|0.675|
|[[:human genes:n:ndufb7|NDUFB7]]|0.674|
|[[:human genes:n:nubpl|NUBPL]]|0.667|
|[[:human genes:n:ndufs2|NDUFS2]]|0.663|
|[[:human genes:n:ndufa11|NDUFA11]]|0.661|
|[[:human genes:n:ndufc2|NDUFC2]]|0.647|
|[[:human genes:m:mto1|MTO1]]|0.632|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.632|
|[[:human genes:g:grsf1|GRSF1]]|0.628|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.623|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.613|
|[[:human genes:n:ndufb4|NDUFB4]]|0.609|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.608|
|[[:human genes:n:ndufc1|NDUFC1]]|0.608|
|[[:human genes:n:ndufa8|NDUFA8]]|0.604|
|[[:human genes:n:ndufs8|NDUFS8]]|0.593|
|[[:human genes:n:ndufb6|NDUFB6]]|0.588|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.583|
|[[:human genes:n:ndufs7|NDUFS7]]|0.582|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.574|
|[[:human genes:n:ndufv1|NDUFV1]]|0.57|
|[[:human genes:e:ecsit|ECSIT]]|0.568|
|[[:human genes:n:ndufs5|NDUFS5]]|0.566|
|[[:human genes:n:ndufa6|NDUFA6]]|0.566|
|[[:human genes:i:iba57|IBA57]]|0.564|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.564|
|[[:human genes:n:ndufb5|NDUFB5]]|0.562|
|[[:human genes:n:ndufa10|NDUFA10]]|0.562|
|[[:human genes:n:ndufb10|NDUFB10]]|0.552|
|[[:human genes:m:mettl17|METTL17]]|0.546|
|[[:human genes:w:wbscr16|WBSCR16]]|0.544|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.543|
|[[:human genes:m:mrpl13|MRPL13]]|0.541|
|[[:human genes:n:ndufs1|NDUFS1]]|0.538|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.538|
|[[:human genes:g:glrx5|GLRX5]]|0.537|
|[[:human genes:n:ndufb2|NDUFB2]]|0.537|
|[[:human genes:q:qrsl1|QRSL1]]|0.534|
|[[:human genes:m:mterfd1|MTERFD1]]|0.528|
|[[:human genes:c:chchd1|CHCHD1]]|0.527|
|[[:human genes:p:polg|POLG]]|0.526|
|[[:human genes:c:c1qbp|C1QBP]]|0.523|
|[[:human genes:m:mtg1|MTG1]]|0.522|
|[[:human genes:m:mrpl21|MRPL21]]|0.521|
|[[:human genes:n:ndufv2|NDUFV2]]|0.517|
|[[:human genes:m:mrpl45|MRPL45]]|0.515|
|[[:human genes:n:ndufa13|NDUFA13]]|0.515|
|[[:human genes:n:nars2|NARS2]]|0.515|
|[[:human genes:n:ndufs3|NDUFS3]]|0.514|
|[[:human genes:d:dap3|DAP3]]|0.514|
|[[:human genes:g:gfm2|GFM2]]|0.511|
|[[:human genes:c:coq7|COQ7]]|0.511|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.51|
|[[:human genes:f:fastkd2|FASTKD2]]|0.509|
|[[:human genes:n:nfu1|NFU1]]|0.509|
|[[:human genes:c:c17orf89|C17orf89]]|0.509|
|[[:human genes:r:rpusd3|RPUSD3]]|0.506|
|[[:human genes:y:yars2|YARS2]]|0.503|
|[[:human genes:f:foxred1|FOXRED1]]|0.502|
|[[:human genes:r:rbfa|RBFA]]|0.501|
|[[:human genes:m:mrps5|MRPS5]]|0.5|
|[[:human genes:a:atp5sl|ATP5SL]]|0.498|
|[[:human genes:m:mrpl47|MRPL47]]|0.498|
|[[:human genes:m:mrps25|MRPS25]]|0.495|
|[[:human genes:m:mrpl15|MRPL15]]|0.49|
|[[:human genes:n:ndufa5|NDUFA5]]|0.488|
|[[:human genes:p:polg2|POLG2]]|0.488|
|[[:human genes:m:mrps21|MRPS21]]|0.488|
|[[:human genes:g:gfm1|GFM1]]|0.487|
|[[:human genes:p:pet112|PET112]]|0.487|
|[[:human genes:m:mrpl3|MRPL3]]|0.487|
|[[:human genes:p:polrmt|POLRMT]]|0.485|
|[[:human genes:s:ssbp1|SSBP1]]|0.482|
|[[:human genes:m:mrp63|MRP63]]|0.481|
|[[:human genes:f:ftsj2|FTSJ2]]|0.481|
|[[:human genes:s:slc25a3|SLC25A3]]|0.478|
|[[:human genes:m:mipep|MIPEP]]|0.478|
|[[:human genes:t:tufm|TUFM]]|0.475|
|[[:human genes:l:lars2|LARS2]]|0.473|
|[[:human genes:m:mrps34|MRPS34]]|0.473|
|[[:human genes:m:mtif2|MTIF2]]|0.472|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.471|
|[[:human genes:p:pet117|PET117]]|0.47|
|[[:human genes:m:mrpl44|MRPL44]]|0.468|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.467|
|[[:human genes:s:slc25a51|SLC25A51]]|0.467|
|[[:human genes:c:c12orf65|C12orf65]]|0.466|
|[[:human genes:m:mrps12|MRPS12]]|0.465|
|[[:human genes:m:mrps6|MRPS6]]|0.464|
|[[:human genes:c:coq2|COQ2]]|0.462|
|[[:human genes:s:sfxn4|SFXN4]]|0.461|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.458|
|[[:human genes:m:mcat|MCAT]]|0.458|
|[[:human genes:g:gatc|GATC]]|0.458|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.457|
|[[:human genes:m:mrps9|MRPS9]]|0.457|
|[[:human genes:d:ddx28|DDX28]]|0.457|
|[[:human genes:d:dars2|DARS2]]|0.455|
|[[:human genes:t:tefm|TEFM]]|0.454|
|[[:human genes:a:aars2|AARS2]]|0.454|
|[[:human genes:t:tfb1m|TFB1M]]|0.453|
|[[:human genes:t:tars2|TARS2]]|0.453|
|[[:human genes:t:trub2|TRUB2]]|0.452|
|[[:human genes:m:mrps27|MRPS27]]|0.452|
|[[:human genes:s:slc25a52|SLC25A52]]|0.448|
|[[:human genes:i:isca2|ISCA2]]|0.446|
|[[:human genes:b:bcs1l|BCS1L]]|0.446|
|[[:human genes:m:mrpl43|MRPL43]]|0.445|
|[[:human genes:r:rars2|RARS2]]|0.445|
|[[:human genes:n:nsun4|NSUN4]]|0.444|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.443|
|[[:human genes:n:ndufb3|NDUFB3]]|0.442|
|[[:human genes:r:rpusd4|RPUSD4]]|0.441|
|[[:human genes:s:slc25a26|SLC25A26]]|0.441|
|[[:human genes:m:mrpl17|MRPL17]]|0.44|
|[[:human genes:p:ptcd3|PTCD3]]|0.439|
|[[:human genes:c:cars2|CARS2]]|0.439|
|[[:human genes:t:tfam|TFAM]]|0.437|
|[[:human genes:n:ndufa9|NDUFA9]]|0.436|
|[[:human genes:m:mrps23|MRPS23]]|0.432|
|[[:human genes:m:mtg2|MTG2]]|0.431|
|[[:human genes:m:mrps14|MRPS14]]|0.431|
|[[:human genes:m:mrpl33|MRPL33]]|0.431|
|[[:human genes:p:pdss1|PDSS1]]|0.431|
|[[:human genes:m:mrps22|MRPS22]]|0.431|
|[[:human genes:c:c10orf2|C10orf2]]|0.431|
|[[:human genes:t:timm21|TIMM21]]|0.428|
|[[:human genes:s:selrc1|SELRC1]]|0.428|
|[[:human genes:a:aifm1|AIFM1]]|0.428|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.428|
|[[:human genes:m:mrpl53|MRPL53]]|0.427|
|[[:human genes:m:mrps16|MRPS16]]|0.427|
|[[:human genes:e:ears2|EARS2]]|0.426|
|[[:human genes:p:pars2|PARS2]]|0.425|
|[[:human genes:m:mrps33|MRPS33]]|0.424|
|[[:human genes:t:tmem261|TMEM261]]|0.423|
|[[:human genes:f:fars2|FARS2]]|0.423|
|[[:human genes:n:ndufb8|NDUFB8]]|0.422|
|[[:human genes:c:cox16|COX16]]|0.422|
|[[:human genes:h:hars2|HARS2]]|0.421|
|[[:human genes:p:pdss2|PDSS2]]|0.42|
|[[:human genes:m:mrpl42|MRPL42]]|0.419|
|[[:human genes:m:mrps26|MRPS26]]|0.417|
|[[:human genes:m:mrpl23|MRPL23]]|0.416|
|[[:human genes:n:noa1|NOA1]]|0.416|
|[[:human genes:w:wars2|WARS2]]|0.415|
|[[:human genes:p:prepl|PREPL]]|0.414|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.413|
|[[:human genes:m:malsu1|MALSU1]]|0.413|
|[[:human genes:p:pnpt1|PNPT1]]|0.412|
|[[:human genes:m:mars2|MARS2]]|0.412|
|[[:human genes:s:sco2|SCO2]]|0.411|
|[[:human genes:a:atp5c1|ATP5C1]]|0.41|
|[[:human genes:p:pde12|PDE12]]|0.407|
|[[:human genes:m:mrps17|MRPS17]]|0.405|
|[[:human genes:m:mrps18b|MRPS18B]]|0.405|
|[[:human genes:m:mrps18a|MRPS18A]]|0.403|
|[[:human genes:m:mrpl38|MRPL38]]|0.401|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.401|
|[[:human genes:i:ict1|ICT1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 14/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|1/28|
|bone|1/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 819
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFB9 Expression in NALM6 Cells: 7.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>