NDUFV2 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= NDUFV2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFV2
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase core subunit V2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4729|4729]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P19404|P19404]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFV2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFV2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600532|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits. The complex is located in the inner mitochondrial membrane. This gene encodes the 24 kDa subunit of complex I, and is involved in electron transfer. Mutations in this gene are implicated in Parkinson's disease, bipolar disorder, schizophrenia, and have been found in one case of early onset hypertrophic cardiomyopathy and encephalopathy. A non-transcribed pseudogene of this locus is found on chromosome 19. [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Complex1 24kDa|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NADH dehydrogenase activity|
|2 iron, 2 sulfur cluster binding|
|NADH dehydrogenase (ubiquinone) activity|
|mitochondrial electron transport, NADH to ubiquinone|
|mitochondrial respiratory chain complex I|
|NADH dehydrogenase complex assembly|
|mitochondrial respiratory chain complex I assembly|
|electron transfer activity|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|respiratory electron transport chain|
|oxidative phosphorylation|
|cardiac muscle tissue development|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|striated muscle tissue development|
|muscle tissue development|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|heart development|
|cellular protein-containing complex assembly|
|circulatory system development|
|oxidation-reduction process|
|mitochondrion|
|phosphorylation|
|protein-containing complex assembly|
|tissue development|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.71|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.71|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|1.74|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.74|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.75|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.76|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|1.77|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.81|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.86|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.87|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.95|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.96|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.05|
|[[:results:exp534|Trientine 500μM R08 exp534]]|2.08|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.36|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nubpl|NUBPL]]|0.597|
|[[:human genes:a:acad9|ACAD9]]|0.566|
|[[:human genes:n:ndufb10|NDUFB10]]|0.563|
|[[:human genes:n:ndufs2|NDUFS2]]|0.554|
|[[:human genes:n:ndufb11|NDUFB11]]|0.553|
|[[:human genes:e:ecsit|ECSIT]]|0.551|
|[[:human genes:n:ndufa2|NDUFA2]]|0.544|
|[[:human genes:n:ndufa11|NDUFA11]]|0.54|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.533|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.524|
|[[:human genes:n:ndufa6|NDUFA6]]|0.523|
|[[:human genes:g:grsf1|GRSF1]]|0.522|
|[[:human genes:n:ndufa8|NDUFA8]]|0.52|
|[[:human genes:n:ndufs5|NDUFS5]]|0.518|
|[[:human genes:n:ndufb9|NDUFB9]]|0.517|
|[[:human genes:m:mto1|MTO1]]|0.511|
|[[:human genes:n:ndufs8|NDUFS8]]|0.51|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.507|
|[[:human genes:n:ndufb6|NDUFB6]]|0.497|
|[[:human genes:n:ndufc1|NDUFC1]]|0.493|
|[[:human genes:n:ndufb7|NDUFB7]]|0.488|
|[[:human genes:n:ndufc2|NDUFC2]]|0.483|
|[[:human genes:n:ndufa1|NDUFA1]]|0.479|
|[[:human genes:n:ndufb2|NDUFB2]]|0.471|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.465|
|[[:human genes:n:ndufa3|NDUFA3]]|0.461|
|[[:human genes:p:pde12|PDE12]]|0.461|
|[[:human genes:n:nsun4|NSUN4]]|0.459|
|[[:human genes:m:malsu1|MALSU1]]|0.459|
|[[:human genes:p:prepl|PREPL]]|0.457|
|[[:human genes:f:fastkd2|FASTKD2]]|0.453|
|[[:human genes:t:tmem261|TMEM261]]|0.452|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.45|
|[[:human genes:n:ndufa10|NDUFA10]]|0.448|
|[[:human genes:p:prim1|PRIM1]]|0.447|
|[[:human genes:p:polg2|POLG2]]|0.447|
|[[:human genes:p:pet117|PET117]]|0.446|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.445|
|[[:human genes:n:ndufa13|NDUFA13]]|0.441|
|[[:human genes:n:ndufb4|NDUFB4]]|0.44|
|[[:human genes:m:mpv17l2|MPV17L2]]|0.44|
|[[:human genes:n:ndufb8|NDUFB8]]|0.439|
|[[:human genes:m:mcat|MCAT]]|0.439|
|[[:human genes:n:ndufa9|NDUFA9]]|0.438|
|[[:human genes:e:eral1|ERAL1]]|0.434|
|[[:human genes:s:slc25a51|SLC25A51]]|0.433|
|[[:human genes:c:chchd1|CHCHD1]]|0.423|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.422|
|[[:human genes:c:c1qbp|C1QBP]]|0.42|
|[[:human genes:n:ndufv1|NDUFV1]]|0.42|
|[[:human genes:r:rmnd1|RMND1]]|0.418|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.416|
|[[:human genes:t:trit1|TRIT1]]|0.415|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.414|
|[[:human genes:t:tfb1m|TFB1M]]|0.412|
|[[:human genes:a:aars2|AARS2]]|0.411|
|[[:human genes:m:mrpl17|MRPL17]]|0.409|
|[[:human genes:m:mettl17|METTL17]]|0.408|
|[[:human genes:n:ndufs7|NDUFS7]]|0.407|
|[[:human genes:f:foxred1|FOXRED1]]|0.407|
|[[:human genes:n:ndufs3|NDUFS3]]|0.405|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 7/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|1/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1348
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFV2 Expression in NALM6 Cells: 5.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>