NECAB2 [The Human Chemical-Genetic Interaction Map Project]

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======= NECAB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NECAB2
  * **<color #00a2e8>Official Name</color>**: N-terminal EF-hand calcium binding protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54550|54550]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z6G3|Q7Z6G3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NECAB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NECAB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618130|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation. {ECO:0000305|PubMed:17689978, ECO:0000305|PubMed:19694902}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ABM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|A2A adenosine receptor binding|
|negative regulation of G protein-coupled receptor internalization|
|positive regulation of adenosine receptor signaling pathway|
|regulation of G protein-coupled receptor internalization|
|regulation of adenosine receptor signaling pathway|
|type 5 metabotropic glutamate receptor binding|
|negative regulation of receptor internalization|
|regulation of amyloid precursor protein biosynthetic process|
|positive regulation of glutamate receptor signaling pathway|
|negative regulation of receptor-mediated endocytosis|
|positive regulation of G protein-coupled receptor signaling pathway|
|regulation of glycoprotein biosynthetic process|
|negative regulation of endocytosis|
|regulation of glycoprotein metabolic process|
|regulation of receptor internalization|
|regulation of glutamate receptor signaling pathway|
|regulation of receptor-mediated endocytosis|
|positive regulation of protein localization to membrane|
|regulation of G protein-coupled receptor signaling pathway|
|regulation of protein localization to membrane|
|regulation of endocytosis|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of ERK1 and ERK2 cascade|
|axon|
|positive regulation of cellular protein localization|
|dendrite|
|negative regulation of transport|
|regulation of cellular protein localization|
|positive regulation of MAPK cascade|
|regulation of vesicle-mediated transport|
|negative regulation of cellular component organization|
|calcium ion binding|
|regulation of MAPK cascade|
|regulation of cellular localization|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|positive regulation of phosphorylation|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of protein modification process|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4142
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NECAB2 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>