NEDD4 [The Human Chemical-Genetic Interaction Map Project]

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======= NEDD4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NEDD4
  * **<color #00a2e8>Official Name</color>**: NEDD4 E3 ubiquitin protein ligase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4734|4734]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P46934|P46934]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NEDD4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NEDD4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602278|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WW|
|C2|
|HECT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transmission of virus|
|dissemination or transmission of symbiont from host|
|development involved in symbiotic interaction|
|dissemination or transmission of organism from other organism involved in symbiotic interaction|
|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|
|phosphothreonine residue binding|
|phosphoserine residue binding|
|regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|
|beta-2 adrenergic receptor binding|
|sodium channel inhibitor activity|
|glucocorticoid receptor signaling pathway|
|corticosteroid receptor signaling pathway|
|progesterone receptor signaling pathway|
|negative regulation of sodium ion transmembrane transporter activity|
|negative regulation of vascular endothelial growth factor receptor signaling pathway|
|negative regulation of sodium ion transmembrane transport|
|RNA polymerase binding|
|proline-rich region binding|
|negative regulation of sodium ion transport|
|apicolateral plasma membrane|
|protein targeting to lysosome|
|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|
|receptor catabolic process|
|regulation of vascular endothelial growth factor receptor signaling pathway|
|protein targeting to vacuole|
|protein localization to lysosome|
|protein K63-linked ubiquitination|
|neuromuscular junction development|
|establishment of protein localization to vacuole|
|regulation of sodium ion transmembrane transporter activity|
|regulation of potassium ion transmembrane transporter activity|
|receptor internalization|
|protein localization to vacuole|
|regulation of sodium ion transmembrane transport|
|positive regulation of nucleocytoplasmic transport|
|intracellular steroid hormone receptor signaling pathway|
|negative regulation of ion transmembrane transporter activity|
|negative regulation of transporter activity|
|ubiquitin binding|
|regulation of potassium ion transmembrane transport|
|negative regulation of cation transmembrane transport|
|cellular response to UV|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|regulation of sodium ion transport|
|regulation of dendrite morphogenesis|
|negative regulation of ion transmembrane transport|
|regulation of potassium ion transport|
|receptor metabolic process|
|ubiquitin ligase complex|
|lysosomal transport|
|regulation of nucleocytoplasmic transport|
|cellular response to light stimulus|
|chromatin|
|negative regulation of transmembrane transport|
|regulation of phosphatidylinositol 3-kinase signaling|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|steroid hormone mediated signaling pathway|
|regulation of DNA-templated transcription in response to stress|
|cell cortex|
|vacuolar transport|
|response to UV|
|negative regulation of cellular response to growth factor stimulus|
|negative regulation of ion transport|
|dendritic spine|
|regulation of dendrite development|
|response to calcium ion|
|interaction with host|
|intracellular receptor signaling pathway|
|hormone-mediated signaling pathway|
|regulation of macroautophagy|
|cellular response to radiation|
|cellular response to steroid hormone stimulus|
|positive regulation of intracellular transport|
|positive regulation of protein catabolic process|
|regulation of synapse organization|
|ubiquitin protein ligase activity|
|regulation of synapse structure or activity|
|receptor-mediated endocytosis|
|protein domain specific binding|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|synapse organization|
|regulation of cellular response to growth factor stimulus|
|regulation of transporter activity|
|protein polyubiquitination|
|regulation of cell morphogenesis involved in differentiation|
|response to light stimulus|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|response to steroid hormone|
|regulation of autophagy|
|regulation of cation transmembrane transport|
|proteasomal protein catabolic process|
|regulation of intracellular transport|
|protein targeting|
|response to metal ion|
|regulation of protein catabolic process|
|regulation of metal ion transport|
|regulation of membrane potential|
|positive regulation of catabolic process|
|establishment of protein localization to organelle|
|response to radiation|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|cellular response to lipid|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|response to inorganic substance|
|cellular response to organic cyclic compound|
|modification-dependent macromolecule catabolic process|
|endocytosis|
|regulation of transmembrane transport|
|proteolysis involved in cellular protein catabolic process|
|cellular response to hormone stimulus|
|cellular protein catabolic process|
|regulation of neuron differentiation|
|neuron projection development|
|import into cell|
|protein catabolic process|
|protein ubiquitination|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|viral process|
|regulation of cell projection organization|
|protein localization to organelle|
|protein modification by small protein conjugation|
|cellular response to DNA damage stimulus|
|symbiotic process|
|neuron development|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|cellular macromolecule catabolic process|
|response to hormone|
|regulation of cellular localization|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|Golgi apparatus|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|regulation of catabolic process|
|intracellular protein transport|
|neuron differentiation|
|positive regulation of intracellular signal transduction|
|macromolecule catabolic process|
|regulation of anatomical structure morphogenesis|
|organonitrogen compound catabolic process|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|response to abiotic stimulus|
|cell projection organization|
|negative regulation of transcription, DNA-templated|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|proteolysis|
|locomotion|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|generation of neurons|
|peptide transport|
|negative regulation of biosynthetic process|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp495|IWR1 50μM R08 exp495]]|1.72|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2886
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NEDD4 Expression in NALM6 Cells: 6.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>