NEDD4L [The Human Chemical-Genetic Interaction Map Project]

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======= NEDD4L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NEDD4L
  * **<color #00a2e8>Official Name</color>**: NEDD4 like E3 ubiquitin protein ligase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23327|23327]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96PU5|Q96PU5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NEDD4L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NEDD4L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606384|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HECT|
|C2|
|WW|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of caveolin-mediated endocytosis|
|regulation of caveolin-mediated endocytosis|
|sodium channel inhibitor activity|
|potassium channel inhibitor activity|
|negative regulation of sodium ion transmembrane transporter activity|
|negative regulation of sodium ion transmembrane transport|
|negative regulation of protein localization to cell surface|
|cellular sodium ion homeostasis|
|negative regulation of sodium ion transport|
|negative regulation of potassium ion transmembrane transporter activity|
|ventricular cardiac muscle cell action potential|
|positive regulation of dendrite extension|
|negative regulation of potassium ion transmembrane transport|
|regulation of dendrite extension|
|negative regulation of potassium ion transport|
|multivesicular body|
|sodium ion homeostasis|
|regulation of membrane repolarization|
|sodium channel regulator activity|
|regulation of protein localization to cell surface|
|cardiac muscle cell action potential involved in contraction|
|potassium channel regulator activity|
|excretion|
|cardiac muscle cell contraction|
|regulation of membrane depolarization|
|cardiac muscle cell action potential|
|protein K48-linked ubiquitination|
|regulation of sodium ion transmembrane transporter activity|
|regulation of potassium ion transmembrane transporter activity|
|protein monoubiquitination|
|regulation of sodium ion transmembrane transport|
|negative regulation of ion transmembrane transporter activity|
|water homeostasis|
|cardiac muscle contraction|
|negative regulation of transporter activity|
|regulation of potassium ion transmembrane transport|
|negative regulation of cation transmembrane transport|
|heart contraction|
|regulation of sodium ion transport|
|actin-mediated cell contraction|
|regulation of dendrite morphogenesis|
|action potential|
|regulation of potassium ion transport|
|negative regulation of ion transmembrane transport|
|heart process|
|positive regulation of endocytosis|
|cellular monovalent inorganic cation homeostasis|
|striated muscle contraction|
|actin filament-based movement|
|negative regulation of cellular protein localization|
|negative regulation of transmembrane transport|
|ion channel binding|
|monovalent inorganic cation homeostasis|
|negative regulation of ion transport|
|regulation of dendrite development|
|sodium ion transport|
|positive regulation of cell growth|
|positive regulation of developmental growth|
|viral life cycle|
|regulation of endocytosis|
|positive regulation of protein catabolic process|
|ubiquitin protein ligase activity|
|ubiquitin-protein transferase activity|
|muscle contraction|
|regulation of ion transmembrane transporter activity|
|positive regulation of growth|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|positive regulation of neuron projection development|
|regulation of protein stability|
|protein polyubiquitination|
|muscle system process|
|regulation of cell morphogenesis involved in differentiation|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|regulation of developmental growth|
|regulation of cation transmembrane transport|
|proteasomal protein catabolic process|
|positive regulation of neuron differentiation|
|response to metal ion|
|positive regulation of cell projection organization|
|regulation of protein catabolic process|
|regulation of metal ion transport|
|blood circulation|
|circulatory system process|
|monovalent inorganic cation transport|
|regulation of cell growth|
|regulation of membrane potential|
|positive regulation of catabolic process|
|positive regulation of neurogenesis|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|response to inorganic substance|
|positive regulation of nervous system development|
|regulation of cellular protein localization|
|positive regulation of cell development|
|modification-dependent macromolecule catabolic process|
|regulation of vesicle-mediated transport|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|actin filament-based process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|regulation of neuron differentiation|
|regulation of growth|
|protein catabolic process|
|protein ubiquitination|
|regulation of plasma membrane bounded cell projection organization|
|regulation of ion transport|
|viral process|
|cation homeostasis|
|regulation of cell projection organization|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|protein modification by small protein conjugation|
|symbiotic process|
|ion homeostasis|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|cation transport|
|negative regulation of transcription by RNA polymerase II|
|cellular homeostasis|
|cellular macromolecule catabolic process|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|ion transmembrane transport|
|positive regulation of cell differentiation|
|Golgi apparatus|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|regulation of catabolic process|
|regulation of protein localization|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|regulation of anatomical structure morphogenesis|
|chemical homeostasis|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|proteolysis|
|transmembrane transport|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|ion transport|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|neurogenesis|
|homeostatic process|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10834
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.53 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NEDD4L Expression in NALM6 Cells: 4.53'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>