NEK1 [The Human Chemical-Genetic Interaction Map Project]

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======= NEK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NEK1
  * **<color #00a2e8>Official Name</color>**: NIMA related kinase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4750|4750]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96PY6|Q96PY6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NEK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NEK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604588|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pericentriolar material|
|14-3-3 protein binding|
|DNA damage response, detection of DNA damage|
|kinase activity|
|protein tyrosine kinase activity|
|stress-activated protein kinase signaling cascade|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|protein kinase activity|
|activation of protein kinase activity|
|cilium assembly|
|protein serine/threonine kinase activity|
|cilium organization|
|signal transduction by protein phosphorylation|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|centrosome|
|cell division|
|positive regulation of protein kinase activity|
|positive regulation of kinase activity|
|positive regulation of transferase activity|
|detection of stimulus|
|organelle assembly|
|cellular response to DNA damage stimulus|
|regulation of protein kinase activity|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|protein phosphorylation|
|regulation of transferase activity|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cell projection organization|
|positive regulation of protein modification process|
|phosphorylation|
|cell cycle|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|ATP binding|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-1.81|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.77|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.71|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|1.71|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.88|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.92|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|2.05|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|2.27|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10673
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NEK1 Expression in NALM6 Cells: 4.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>