NEMF [The Human Chemical-Genetic Interaction Map Project]

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======= NEMF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NEMF
  * **<color #00a2e8>Official Name</color>**: nuclear export mediator factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9147|9147]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60524|O60524]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NEMF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NEMF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608378|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a component of the ribosome quality control complex. The encoded protein facilitates the recognition and ubiquitination of stalled 60S subunits by the ubiquitin ligase listerin. A similar protein in fly functions as a tumor suppressor. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF814|
|DUF3441|
|FbpA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RQC complex|
|ribosome-associated ubiquitin-dependent protein catabolic process|
|rescue of stalled ribosome|
|ribosomal large subunit binding|
|tRNA binding|
|translational elongation|
|nuclear export|
|nucleocytoplasmic transport|
|nuclear transport|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|regulation of translation|
|translation|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|posttranscriptional regulation of gene expression|
|ubiquitin-dependent protein catabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|cellular amide metabolic process|
|cellular macromolecule catabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|proteolysis|
|organonitrogen compound biosynthetic process|
|intracellular transport|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-2.61|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.3|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-2.07|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.87|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.84|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.8|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.8|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-1.75|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.7|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|1.71|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|1.77|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.441|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4841
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NEMF Expression in NALM6 Cells: 6.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>