NEUROG1 [The Human Chemical-Genetic Interaction Map Project]

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======= NEUROG1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NEUROG1
  * **<color #00a2e8>Official Name</color>**: neurogenin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4762|4762]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92886|Q92886]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NEUROG1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NEUROG1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601726|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HLH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hard palate morphogenesis|
|mastication|
|negative regulation of saliva secretion|
|learned vocalization behavior|
|negative regulation of relaxation of muscle|
|vestibulocochlear nerve formation|
|thorax and anterior abdomen determination|
|positive regulation of exit from mitosis|
|zygotic determination of anterior/posterior axis, embryo|
|vestibulocochlear nerve morphogenesis|
|regulation of saliva secretion|
|cranial nerve formation|
|peristalsis|
|vestibulocochlear nerve development|
|learned vocalization behavior or vocal learning|
|regulation of relaxation of muscle|
|trigeminal nerve development|
|auditory behavior|
|genitalia morphogenesis|
|sequence-specific double-stranded DNA binding|
|mechanosensory behavior|
|anterior/posterior axis specification, embryo|
|tripartite regional subdivision|
|vocalization behavior|
|craniofacial suture morphogenesis|
|phasic smooth muscle contraction|
|blastoderm segmentation|
|negative regulation of digestive system process|
|regulation of exit from mitosis|
|cochlea morphogenesis|
|response to auditory stimulus|
|cranial nerve morphogenesis|
|embryonic axis specification|
|regulation of digestive system process|
|genitalia development|
|anterior/posterior axis specification|
|E-box binding|
|cochlea development|
|cranial nerve development|
|neuromuscular process controlling balance|
|smooth muscle contraction|
|positive regulation of mitotic nuclear division|
|embryonic pattern specification|
|positive regulation of nuclear division|
|cranial skeletal system development|
|digestive system process|
|positive regulation of mitotic cell cycle phase transition|
|nerve development|
|axis specification|
|positive regulation of cell cycle phase transition|
|segmentation|
|inner ear morphogenesis|
|neuromuscular process|
|digestion|
|bone morphogenesis|
|ear morphogenesis|
|perikaryon|
|regulation of muscle organ development|
|positive regulation of mitotic cell cycle|
|regulation of mitotic nuclear division|
|regulation of nuclear division|
|inner ear development|
|bone development|
|response to mechanical stimulus|
|anterior/posterior pattern specification|
|ear development|
|negative regulation of secretion|
|regulation of muscle system process|
|skeletal system morphogenesis|
|cell fate commitment|
|muscle contraction|
|sensory organ morphogenesis|
|learning or memory|
|positive regulation of DNA-binding transcription factor activity|
|sex differentiation|
|positive regulation of cell cycle process|
|embryonic organ morphogenesis|
|cognition|
|muscle system process|
|regionalization|
|positive regulation of neuron differentiation|
|positive regulation of cell cycle|
|chromatin binding|
|regulation of mitotic cell cycle phase transition|
|reproductive structure development|
|regulation of DNA-binding transcription factor activity|
|reproductive system development|
|embryonic organ development|
|pattern specification process|
|regulation of cell cycle phase transition|
|positive regulation of neurogenesis|
|negative regulation of transport|
|skeletal system development|
|regulation of body fluid levels|
|positive regulation of nervous system development|
|positive regulation of cell development|
|sensory organ development|
|embryonic morphogenesis|
|behavior|
|regulation of system process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|regulation of neuron differentiation|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|regulation of cell cycle process|
|regulation of secretion|
|regulation of neurogenesis|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|embryo development|
|neuron differentiation|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|regulation of organelle organization|
|positive regulation of developmental process|
|nervous system process|
|reproductive process|
|reproduction|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-2.28|
|[[:results:exp73|LJH685 5μM R02 exp73]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5428
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NEUROG1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>