NFATC1 [The Human Chemical-Genetic Interaction Map Project]

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======= NFATC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NFATC1
  * **<color #00a2e8>Official Name</color>**: nuclear factor of activated T cells 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4772|4772]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95644|O95644]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NFATC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NFATC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600489|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RHD|
|TIG|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase II transcription coactivator binding|
|mitogen-activated protein kinase p38 binding|
|negative regulation of vascular smooth muscle cell differentiation|
|FK506 binding|
|calcineurin-NFAT signaling cascade|
|regulation of vascular smooth muscle cell differentiation|
|calcineurin-mediated signaling|
|negative regulation of smooth muscle cell differentiation|
|pulmonary valve morphogenesis|
|pulmonary valve development|
|nuclear transcription factor complex|
|inositol phosphate-mediated signaling|
|aortic valve morphogenesis|
|regulation of smooth muscle cell differentiation|
|aortic valve development|
|semi-lunar valve development|
|Wnt signaling pathway, calcium modulating pathway|
|heart valve morphogenesis|
|negative regulation of muscle cell differentiation|
|heart valve development|
|RNA polymerase II transcription factor binding|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|negative regulation of vasculature development|
|non-canonical Wnt signaling pathway|
|calcium-mediated signaling|
|cytokine production|
|regulation of muscle cell differentiation|
|Fc-epsilon receptor signaling pathway|
|transcription factor complex|
|negative regulation of Wnt signaling pathway|
|nuclear chromatin|
|Fc receptor signaling pathway|
|nuclear body|
|regulation of vasculature development|
|transcription factor binding|
|second-messenger-mediated signaling|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|chromatin binding|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|immune response-regulating cell surface receptor signaling pathway|
|transcription by RNA polymerase II|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|heart development|
|immune response-regulating signaling pathway|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|DNA-binding transcription factor activity|
|negative regulation of cell differentiation|
|circulatory system development|
|negative regulation of developmental process|
|nucleobase-containing compound biosynthetic process|
|cell-cell signaling|
|regulation of immune response|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of signal transduction|
|organic cyclic compound biosynthetic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|RNA metabolic process|
|intracellular signal transduction|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-2.34|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|-2.02|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15144
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.22 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NFATC1 Expression in NALM6 Cells: 3.22'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>