NFATC2 [The Human Chemical-Genetic Interaction Map Project]

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======= NFATC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NFATC2
  * **<color #00a2e8>Official Name</color>**: nuclear factor of activated T cells 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4773|4773]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13469|Q13469]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NFATC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NFATC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600490|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TIG|
|RHD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of vascular smooth muscle cell differentiation|
|calcineurin-NFAT signaling cascade|
|regulation of vascular smooth muscle cell differentiation|
|calcineurin-mediated signaling|
|negative regulation of smooth muscle cell differentiation|
|positive regulation of myoblast fusion|
|regulation of myoblast fusion|
|inositol phosphate-mediated signaling|
|nuclear transcription factor complex|
|positive regulation of syncytium formation by plasma membrane fusion|
|myotube cell development|
|regulation of syncytium formation by plasma membrane fusion|
|regulation of regulatory T cell differentiation|
|regulation of smooth muscle cell differentiation|
|positive regulation of myotube differentiation|
|positive regulation of B cell proliferation|
|phosphatase binding|
|negative regulation of muscle cell differentiation|
|regulation of myotube differentiation|
|myotube differentiation|
|positive regulation of striated muscle cell differentiation|
|regulation of B cell proliferation|
|positive regulation of muscle cell differentiation|
|regulation of striated muscle cell differentiation|
|negative regulation of vasculature development|
|B cell receptor signaling pathway|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|striated muscle cell development|
|positive regulation of leukocyte proliferation|
|regulation of T cell differentiation|
|calcium-mediated signaling|
|muscle cell development|
|cytokine production|
|regulation of muscle cell differentiation|
|ribonucleoprotein complex|
|positive regulation of B cell activation|
|regulation of lymphocyte differentiation|
|Fc-epsilon receptor signaling pathway|
|striated muscle cell differentiation|
|transcription factor complex|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|regulation of leukocyte proliferation|
|nuclear chromatin|
|Fc receptor signaling pathway|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|muscle cell differentiation|
|regulation of leukocyte differentiation|
|antigen receptor-mediated signaling pathway|
|regulation of T cell activation|
|regulation of vasculature development|
|transcription factor binding|
|second-messenger-mediated signaling|
|positive regulation of lymphocyte activation|
|chromatin binding|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|immune response-activating cell surface receptor signaling pathway|
|regulation of hemopoiesis|
|muscle structure development|
|immune response-regulating cell surface receptor signaling pathway|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|regulation of lymphocyte activation|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|activation of immune response|
|regulation of cell activation|
|DNA-binding transcription factor activity|
|negative regulation of cell differentiation|
|cellular response to DNA damage stimulus|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|cell migration|
|positive regulation of cell differentiation|
|response to drug|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|locomotion|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of immune system process|
|intracellular signal transduction|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8876
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NFATC2 Expression in NALM6 Cells: 2.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>