NFATC3 [The Human Chemical-Genetic Interaction Map Project]

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======= NFATC3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NFATC3
  * **<color #00a2e8>Official Name</color>**: nuclear factor of activated T cells 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4775|4775]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12968|Q12968]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NFATC3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NFATC3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602698|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2. {ECO:0000269|PubMed:18815128}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RHD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of vascular smooth muscle cell differentiation|
|calcineurin-NFAT signaling cascade|
|negative regulation of pri-miRNA transcription by RNA polymerase II|
|regulation of vascular smooth muscle cell differentiation|
|calcineurin-mediated signaling|
|negative regulation of smooth muscle cell differentiation|
|inositol phosphate-mediated signaling|
|nuclear transcription factor complex|
|regulation of smooth muscle cell differentiation|
|regulation of pri-miRNA transcription by RNA polymerase II|
|negative regulation of muscle cell differentiation|
|negative regulation of vasculature development|
|calcium-mediated signaling|
|cytokine production|
|regulation of muscle cell differentiation|
|Fc-epsilon receptor signaling pathway|
|transcription factor complex|
|Fc receptor signaling pathway|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|regulation of vasculature development|
|transcription factor binding|
|second-messenger-mediated signaling|
|chromatin binding|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|transcription by RNA polymerase II|
|immune response-regulating cell surface receptor signaling pathway|
|inflammatory response|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|immune response-regulating signaling pathway|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|DNA-binding transcription factor activity|
|negative regulation of cell differentiation|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of developmental process|
|nucleobase-containing compound biosynthetic process|
|regulation of immune response|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|RNA metabolic process|
|intracellular signal transduction|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.62|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.91|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.71|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.71|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-1.7|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.71|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.72|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.72|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.73|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.74|
|[[:results:exp100|NFN1 1μM R03 exp100]]|1.75|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|1.78|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.78|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.81|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.82|
|[[:results:exp73|LJH685 5μM R02 exp73]]|1.9|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.9|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|2.05|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|2.06|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.09|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|2.13|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|2.16|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.3|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|2.33|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.6|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|2.7|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|3.52|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|4.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:ppp3r1|PPP3R1]]|0.655|
|[[:human genes:p:ppp3ca|PPP3CA]]|0.632|
|[[:human genes:i:itpr1|ITPR1]]|0.547|
|[[:human genes:r:rrm1|RRM1]]|0.517|
|[[:human genes:p:poldip2|POLDIP2]]|0.417|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3329
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NFATC3 Expression in NALM6 Cells: 6.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>