NFATC4 [The Human Chemical-Genetic Interaction Map Project]

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======= NFATC4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NFATC4
  * **<color #00a2e8>Official Name</color>**: nuclear factor of activated T cells 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4776|4776]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14934|Q14934]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NFATC4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NFATC4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602699|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RHD|
|TIG|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of synapse maturation|
|cellular response to ionomycin|
|response to ionomycin|
|cellular response to ether|
|brain-derived neurotrophic factor receptor signaling pathway|
|negative regulation of chromatin binding|
|calcineurin-NFAT signaling cascade|
|response to ether|
|peroxisome proliferator activated receptor binding|
|negative regulation of pri-miRNA transcription by RNA polymerase II|
|cellular response to lithium ion|
|regulation of synapse maturation|
|calcineurin-mediated signaling|
|negative regulation of dendrite morphogenesis|
|response to lithium ion|
|regulation of chromatin binding|
|nuclear transcription factor complex|
|negative regulation of synapse organization|
|inositol phosphate-mediated signaling|
|branching involved in blood vessel morphogenesis|
|negative regulation of dendrite development|
|smooth muscle cell differentiation|
|long-term memory|
|regulation of pri-miRNA transcription by RNA polymerase II|
|long-term synaptic potentiation|
|cellular response to fatty acid|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|cellular response to UV|
|response to fatty acid|
|positive regulation of tumor necrosis factor production|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|regulation of dendrite morphogenesis|
|negative regulation of cell morphogenesis involved in differentiation|
|negative regulation of protein binding|
|cellular response to light stimulus|
|memory|
|branching morphogenesis of an epithelial tube|
|response to UV|
|negative regulation of neuron apoptotic process|
|calcium-mediated signaling|
|intrinsic apoptotic signaling pathway|
|regulation of tumor necrosis factor production|
|muscle cell development|
|cytokine production|
|regulation of dendrite development|
|positive regulation of synaptic transmission|
|regulation of tumor necrosis factor superfamily cytokine production|
|negative regulation of neuron projection development|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|cellular respiration|
|negative regulation of binding|
|positive regulation of apoptotic signaling pathway|
|cellular response to radiation|
|negative regulation of cell projection organization|
|regulation of synaptic plasticity|
|cellular response to metal ion|
|transcription factor complex|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|cellular response to acid chemical|
|negative regulation of Wnt signaling pathway|
|regulation of synapse organization|
|regulation of protein binding|
|cellular response to inorganic substance|
|negative regulation of neuron differentiation|
|regulation of synapse structure or activity|
|energy derivation by oxidation of organic compounds|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|muscle cell differentiation|
|learning or memory|
|transcription coactivator activity|
|apoptotic signaling pathway|
|negative regulation of neurogenesis|
|cognition|
|regulation of cell morphogenesis involved in differentiation|
|epithelial tube morphogenesis|
|response to light stimulus|
|regulation of neuron death|
|negative regulation of nervous system development|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|angiogenesis|
|transcription factor binding|
|negative regulation of cell development|
|second-messenger-mediated signaling|
|response to acid chemical|
|regulation of Wnt signaling pathway|
|response to metal ion|
|regulation of binding|
|chromatin binding|
|regulation of apoptotic signaling pathway|
|nuclear speck|
|blood vessel morphogenesis|
|generation of precursor metabolites and energy|
|morphogenesis of an epithelium|
|response to radiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|positive regulation of cytokine production|
|muscle structure development|
|transcription by RNA polymerase II|
|blood vessel development|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|inflammatory response|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|vasculature development|
|cardiovascular system development|
|cellular response to lipid|
|heart development|
|response to inorganic substance|
|cellular response to organic cyclic compound|
|tissue morphogenesis|
|behavior|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|RNA biosynthetic process|
|tube morphogenesis|
|regulation of neuron differentiation|
|DNA-binding transcription factor activity|
|regulation of cytokine production|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|cellular response to DNA damage stimulus|
|regulation of neurogenesis|
|tube development|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|response to organic cyclic compound|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|oxidation-reduction process|
|negative regulation of cell death|
|programmed cell death|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|cell death|
|nucleobase-containing compound biosynthetic process|
|epithelium development|
|negative regulation of molecular function|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|RNA metabolic process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.506|
|[[:human genes:p:prim1|PRIM1]]|0.497|
|[[:human genes:p:psmb4|PSMB4]]|0.495|
|[[:human genes:n:nup160|NUP160]]|0.485|
|[[:human genes:o:orc1|ORC1]]|0.485|
|[[:human genes:r:rps2|RPS2]]|0.484|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.481|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.479|
|[[:human genes:p:polr2j3|POLR2J3]]|0.479|
|[[:human genes:r:rps12|RPS12]]|0.475|
|[[:human genes:c:copg1|COPG1]]|0.473|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.469|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.468|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.468|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.467|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.467|
|[[:human genes:r:rpl35|RPL35]]|0.467|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.467|
|[[:human genes:t:tceb3c|TCEB3C]]|0.464|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.462|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.461|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.461|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.46|
|[[:human genes:t:twistnb|TWISTNB]]|0.46|
|[[:human genes:k:kctd17|KCTD17]]|0.459|
|[[:human genes:a:acsf2|ACSF2]]|0.458|
|[[:human genes:c:ccna2|CCNA2]]|0.455|
|[[:human genes:v:vasn|VASN]]|0.455|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.454|
|[[:human genes:t:tfip11|TFIP11]]|0.453|
|[[:human genes:c:cbwd3|CBWD3]]|0.453|
|[[:human genes:t:timeless|TIMELESS]]|0.45|
|[[:human genes:n:nupl1|NUPL1]]|0.45|
|[[:human genes:c:cbwd5|CBWD5]]|0.449|
|[[:human genes:u:upf1|UPF1]]|0.447|
|[[:human genes:r:rrp7a|RRP7A]]|0.446|
|[[:human genes:c:cbwd6|CBWD6]]|0.445|
|[[:human genes:t:traip|TRAIP]]|0.443|
|[[:human genes:s:sap30bp|SAP30BP]]|0.441|
|[[:human genes:u:utp3|UTP3]]|0.441|
|[[:human genes:r:rbm39|RBM39]]|0.44|
|[[:human genes:t:tspy8|TSPY8]]|0.439|
|[[:human genes:a:aatf|AATF]]|0.438|
|[[:human genes:p:psmb1|PSMB1]]|0.438|
|[[:human genes:p:pola1|POLA1]]|0.438|
|[[:human genes:p:psma7|PSMA7]]|0.435|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.435|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.435|
|[[:human genes:r:rps28|RPS28]]|0.434|
|[[:human genes:n:nsf|NSF]]|0.434|
|[[:human genes:h:hap1|HAP1]]|0.434|
|[[:human genes:c:chd4|CHD4]]|0.433|
|[[:human genes:n:nup133|NUP133]]|0.431|
|[[:human genes:d:dtl|DTL]]|0.431|
|[[:human genes:p:psmb2|PSMB2]]|0.431|
|[[:human genes:p:pole|POLE]]|0.428|
|[[:human genes:d:ddtl|DDTL]]|0.428|
|[[:human genes:p:psmc2|PSMC2]]|0.428|
|[[:human genes:m:med17|MED17]]|0.428|
|[[:human genes:o:orc6|ORC6]]|0.427|
|[[:human genes:p:psmb3|PSMB3]]|0.427|
|[[:human genes:a:akirin2|AKIRIN2]]|0.427|
|[[:human genes:g:gid4|GID4]]|0.424|
|[[:human genes:w:wdr75|WDR75]]|0.42|
|[[:human genes:c:cdc45|CDC45]]|0.42|
|[[:human genes:p:pigs|PIGS]]|0.419|
|[[:human genes:c:col2a1|COL2A1]]|0.418|
|[[:human genes:p:polr2f|POLR2F]]|0.414|
|[[:human genes:m:mrs2|MRS2]]|0.414|
|[[:human genes:m:mt1e|MT1E]]|0.413|
|[[:human genes:z:znf655|ZNF655]]|0.413|
|[[:human genes:p:psma6|PSMA6]]|0.411|
|[[:human genes:e:eftud2|EFTUD2]]|0.41|
|[[:human genes:p:psap|PSAP]]|0.408|
|[[:human genes:c:cdc73|CDC73]]|0.406|
|[[:human genes:z:znf574|ZNF574]]|0.405|
|[[:human genes:t:ticrr|TICRR]]|0.405|
|[[:human genes:c:cope|COPE]]|0.404|
|[[:human genes:r:rpl9|RPL9]]|0.403|
|[[:human genes:a:arcn1|ARCN1]]|0.403|
|[[:human genes:g:gga3|GGA3]]|0.402|
|[[:human genes:c:copz1|COPZ1]]|0.402|
|[[:human genes:c:copb1|COPB1]]|0.402|
|[[:human genes:g:gpr114|GPR114]]|0.4|
|[[:human genes:p:polr2l|POLR2L]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2223
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NFATC4 Expression in NALM6 Cells: 5.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>