NFYA [The Human Chemical-Genetic Interaction Map Project]

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======= NFYA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NFYA
  * **<color #00a2e8>Official Name</color>**: nuclear transcription factor Y subunit alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4800|4800]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P23511|P23511]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NFYA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NFYA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/189903|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'- CCAAT-3' box motif found in the promoters of its target genes. NF- Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1. {ECO:0000269|PubMed:12741956}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CBFB NFYA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CCAAT-binding factor complex|
|regulation of sterol biosynthetic process|
|regulation of cholesterol biosynthetic process|
|protein-DNA complex|
|regulation of cholesterol metabolic process|
|RNA polymerase II transcription factor complex|
|regulation of alcohol biosynthetic process|
|regulation of steroid biosynthetic process|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|regulation of steroid metabolic process|
|regulation of lipid biosynthetic process|
|transcription regulatory region DNA binding|
|rhythmic process|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|transcription by RNA polymerase II|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|DNA-binding transcription factor activity|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|DNA binding|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.35|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-2.02|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-1.95|
|[[:results:exp100|NFN1 1μM R03 exp100]]|1.71|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|1.83|
|[[:results:exp519|RS-1 10μM R08 exp519]]|1.92|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.15|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|2.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.559|
|[[:human genes:p:polr2j3|POLR2J3]]|0.53|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.451|
|[[:human genes:t:tceb3c|TCEB3C]]|0.433|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.429|
|[[:human genes:m:mbtd1|MBTD1]]|0.425|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.424|
|[[:human genes:p:prim1|PRIM1]]|0.419|
|[[:human genes:s:supt5h|SUPT5H]]|0.416|
|[[:human genes:v:vps28|VPS28]]|0.408|
|[[:human genes:p:prpf19|PRPF19]]|0.406|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1302
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NFYA Expression in NALM6 Cells: 6.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>