NKAP [The Human Chemical-Genetic Interaction Map Project]

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======= NKAP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NKAP
  * **<color #00a2e8>Official Name</color>**: NFKB activating protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79576|79576]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N5F7|Q8N5F7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NKAP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NKAP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300766|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6. [provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter. {ECO:0000269|PubMed:14550261, ECO:0000269|PubMed:19409814}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SynMuv product|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hematopoietic stem cell proliferation|
|granulocyte differentiation|
|positive regulation of alpha-beta T cell differentiation|
|T cell differentiation in thymus|
|stem cell proliferation|
|positive regulation of alpha-beta T cell activation|
|regulation of alpha-beta T cell differentiation|
|chromatin DNA binding|
|positive regulation of T cell differentiation|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|myeloid leukocyte differentiation|
|Notch signaling pathway|
|T cell differentiation|
|stem cell population maintenance|
|maintenance of cell number|
|regulation of T cell differentiation|
|positive regulation of leukocyte differentiation|
|regulation of lymphocyte differentiation|
|positive regulation of hemopoiesis|
|positive regulation of T cell activation|
|positive regulation of leukocyte cell-cell adhesion|
|myeloid cell differentiation|
|T cell activation|
|lymphocyte differentiation|
|positive regulation of cell-cell adhesion|
|regulation of leukocyte differentiation|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|leukocyte differentiation|
|positive regulation of lymphocyte activation|
|lymphocyte activation|
|chromatin binding|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|regulation of hemopoiesis|
|regulation of lymphocyte activation|
|cell population proliferation|
|hemopoiesis|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|regulation of cell activation|
|immune system development|
|regulation of cell adhesion|
|negative regulation of transcription by RNA polymerase II|
|leukocyte activation|
|positive regulation of cell differentiation|
|cell activation|
|positive regulation of immune system process|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of immune system process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp116|AICAR 240μM R03 exp116]]|-2.33|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-2.01|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.92|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|-1.74|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.73|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.7|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|1.73|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|1.73|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|1.76|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|1.82|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|1.98|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|2.07|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.61|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.441|
|[[:human genes:r:rad51|RAD51]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 606/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|24/28|
|blood|24/26|
|bone|25/26|
|breast|23/30|
|central nervous system|42/49|
|cervix|3/4|
|colorectal|16/17|
|esophagus|9/11|
|fibroblast|1/1|
|gastric|13/14|
|kidney|15/18|
|liver|13/19|
|lung|61/72|
|lymphocyte|15/16|
|ovary|22/25|
|pancreas|17/22|
|peripheral nervous system|13/15|
|plasma cell|12/12|
|prostate|1/1|
|skin|19/20|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|26/28|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1915
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NKAP Expression in NALM6 Cells: 5.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>