NKX2-2 [The Human Chemical-Genetic Interaction Map Project]

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======= NKX2-2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NKX2-2
  * **<color #00a2e8>Official Name</color>**: NK2 homeobox 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4821|4821]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95096|O95096]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NKX2-2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NKX2-2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604612|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|type B pancreatic cell fate commitment|
|ventral spinal cord interneuron fate determination|
|cell fate determination involved in pattern specification|
|pancreatic A cell fate commitment|
|pancreatic PP cell fate commitment|
|pancreatic PP cell differentiation|
|spinal cord oligodendrocyte cell fate specification|
|spinal cord oligodendrocyte cell differentiation|
|glial cell fate specification|
|oligodendrocyte cell fate commitment|
|oligodendrocyte cell fate specification|
|pancreatic A cell differentiation|
|neuron fate determination|
|optic nerve development|
|type B pancreatic cell development|
|glial cell fate commitment|
|epithelial cell fate commitment|
|cell fate commitment involved in pattern specification|
|ventral spinal cord interneuron fate commitment|
|ventral spinal cord interneuron differentiation|
|glandular epithelial cell development|
|type B pancreatic cell differentiation|
|enteroendocrine cell differentiation|
|spinal cord dorsal/ventral patterning|
|positive regulation of oligodendrocyte differentiation|
|spinal cord patterning|
|proximal promoter sequence-specific DNA binding|
|neuron fate specification|
|spinal cord motor neuron differentiation|
|endocrine pancreas development|
|glandular epithelial cell differentiation|
|regulation of oligodendrocyte differentiation|
|cell fate determination|
|positive regulation of glial cell differentiation|
|oligodendrocyte development|
|response to progesterone|
|ventral spinal cord development|
|columnar/cuboidal epithelial cell development|
|cranial nerve development|
|astrocyte differentiation|
|cell differentiation in spinal cord|
|neuron fate commitment|
|positive regulation of gliogenesis|
|oligodendrocyte differentiation|
|regulation of glial cell differentiation|
|pancreas development|
|smoothened signaling pathway|
|nerve development|
|dorsal/ventral pattern formation|
|cell fate specification|
|columnar/cuboidal epithelial cell differentiation|
|glial cell development|
|spinal cord development|
|regulation of gliogenesis|
|endocrine system development|
|digestive tract development|
|response to glucose|
|digestive system development|
|response to hexose|
|response to monosaccharide|
|glial cell differentiation|
|response to carbohydrate|
|central nervous system neuron differentiation|
|epithelial cell development|
|response to ketone|
|gliogenesis|
|negative regulation of neuron differentiation|
|cell fate commitment|
|positive regulation of DNA-binding transcription factor activity|
|transcription coactivator activity|
|negative regulation of neurogenesis|
|negative regulation of nervous system development|
|response to steroid hormone|
|transcription factor binding|
|regionalization|
|negative regulation of cell development|
|positive regulation of neuron differentiation|
|chromatin binding|
|sequence-specific DNA binding|
|regulation of DNA-binding transcription factor activity|
|pattern specification process|
|positive regulation of neurogenesis|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|positive regulation of nervous system development|
|positive regulation of cell development|
|regulation of neuron differentiation|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|negative regulation of cell differentiation|
|brain development|
|head development|
|regulation of neurogenesis|
|tube development|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|central nervous system development|
|neuron differentiation|
|response to drug|
|epithelium development|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of developmental process|
|response to endogenous stimulus|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16450
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NKX2-2 Expression in NALM6 Cells: -2.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>