NKX2-3 [The Human Chemical-Genetic Interaction Map Project]

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======= NKX2-3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NKX2-3
  * **<color #00a2e8>Official Name</color>**: NK2 homeobox 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=159296|159296]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TAU0|Q8TAU0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NKX2-3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NKX2-3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606727|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a homeodomain-containing transcription factor. The encoded protein is a member of the NKX family of homeodomain transcription factors. Studies of similar proteins in mouse and rat have indicated a potential role in cellular differentiation.[provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|post-embryonic digestive tract morphogenesis|
|plasma cell differentiation|
|mucosal-associated lymphoid tissue development|
|Peyers patch development|
|post-embryonic animal morphogenesis|
|lymph node development|
|mature B cell differentiation involved in immune response|
|mature B cell differentiation|
|macrophage differentiation|
|spleen development|
|CD4-positive, alpha-beta T cell differentiation|
|CD4-positive, alpha-beta T cell activation|
|B cell activation involved in immune response|
|digestive tract morphogenesis|
|alpha-beta T cell differentiation|
|alpha-beta T cell activation|
|leukocyte homeostasis|
|triglyceride metabolic process|
|odontogenesis of dentin-containing tooth|
|post-embryonic development|
|acylglycerol metabolic process|
|gland morphogenesis|
|neutral lipid metabolic process|
|B cell differentiation|
|lymphocyte activation involved in immune response|
|myeloid leukocyte differentiation|
|odontogenesis|
|digestive tract development|
|T cell differentiation|
|digestive system development|
|B cell activation|
|homeostasis of number of cells|
|myeloid cell differentiation|
|T cell activation|
|lymphocyte differentiation|
|leukocyte differentiation|
|leukocyte migration|
|glycerolipid metabolic process|
|lymphocyte activation|
|gland development|
|sequence-specific DNA binding|
|cellular component|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|immune system development|
|tube morphogenesis|
|DNA-binding transcription factor activity|
|molecular function|
|tube development|
|leukocyte activation|
|cellular lipid metabolic process|
|animal organ morphogenesis|
|cell migration|
|cell activation|
|cell motility|
|localization of cell|
|immune effector process|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|locomotion|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of RNA metabolic process|
|tissue development|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13249
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NKX2-3 Expression in NALM6 Cells: -3.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>