NLRC3 [The Human Chemical-Genetic Interaction Map Project]

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======= NLRC3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NLRC3
  * **<color #00a2e8>Official Name</color>**: NLR family CARD domain containing 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=197358|197358]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7RTR2|Q7RTR2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NLRC3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NLRC3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615648|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption of STING-dependent activation of the innate immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Negative regulator of the innate immune response (PubMed:15705585, PubMed:22863753, PubMed:25277106). Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA:dT), but not poly(I:C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1) (By similarity) (PubMed:22863753). May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating 'Lys-63'- linked ubiquitination and leaving unchanged the degradative 'Lys- 48'-linked ubiquitination (PubMed:22863753). Inhibits the PI3K- AKT-mTOR pathway possibly by directly interacting with the posphatidylinositol 3-kinase regulatory subunit p85 (PIK3R1/PIK3R2) and disrupting the association between PIK3R1/PIK3R2 and the catalytic subunit p110 (PIK3CA/PIK3CB/PIK3CD) and reducing PIK3R1/PIK3R2 activation. Via its regulation of the PI3K-AKT-mTOR pathway, controls cell proliferation, predominantly in intestinal epithelial cells (By similarity). May also affect NOD1- or NOD2-mediated NF-kappa-B activation (PubMed:25277106). Might also affect the inflammatory response by preventing NLRP3 inflammasome formation, CASP1 cleavage and IL1B maturation (PubMed:25277106). {ECO:0000250|UniProtKB:Q5DU56, ECO:0000269|PubMed:15705585, ECO:0000269|PubMed:22863753, ECO:0000269|PubMed:25277106}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NACHT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of interferon-alpha production|
|negative regulation of NLRP3 inflammasome complex assembly|
|phosphatidylinositol 3-kinase regulatory subunit binding|
|negative regulation of phosphatidylinositol 3-kinase signaling|
|negative regulation of interferon-beta production|
|regulation of NLRP3 inflammasome complex assembly|
|negative regulation of cytokine production involved in inflammatory response|
|negative regulation of NIK/NF-kappaB signaling|
|negative regulation of fibroblast proliferation|
|regulation of interferon-alpha production|
|regulation of cytokine production involved in inflammatory response|
|negative regulation of I-kappaB kinase/NF-kappaB signaling|
|negative regulation of interleukin-6 production|
|negative regulation of type I interferon production|
|regulation of interferon-beta production|
|negative regulation of innate immune response|
|negative regulation of tumor necrosis factor production|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|I-kappaB kinase/NF-kappaB signaling|
|regulation of fibroblast proliferation|
|negative regulation of NF-kappaB transcription factor activity|
|negative regulation of response to biotic stimulus|
|regulation of NIK/NF-kappaB signaling|
|regulation of phosphatidylinositol 3-kinase signaling|
|negative regulation of epithelial cell proliferation|
|regulation of type I interferon production|
|negative regulation of protein complex assembly|
|negative regulation of inflammatory response|
|regulation of interleukin-6 production|
|regulation of tumor necrosis factor production|
|negative regulation of immune response|
|regulation of tumor necrosis factor superfamily cytokine production|
|microtubule organizing center|
|negative regulation of DNA-binding transcription factor activity|
|negative regulation of defense response|
|negative regulation of multi-organism process|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|T cell activation|
|negative regulation of cytokine production|
|regulation of epithelial cell proliferation|
|regulation of inflammatory response|
|negative regulation of response to external stimulus|
|lymphocyte activation|
|regulation of DNA-binding transcription factor activity|
|negative regulation of immune system process|
|regulation of protein complex assembly|
|regulation of innate immune response|
|negative regulation of intracellular signal transduction|
|regulation of response to biotic stimulus|
|negative regulation of cell population proliferation|
|regulation of cytokine production|
|perinuclear region of cytoplasm|
|negative regulation of cellular component organization|
|molecular function|
|regulation of defense response|
|regulation of multi-organism process|
|leukocyte activation|
|regulation of cellular component biogenesis|
|cell activation|
|regulation of response to external stimulus|
|negative regulation of molecular function|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|ATP binding|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|intracellular signal transduction|
|regulation of intracellular signal transduction|
</modal>
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 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5560
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NLRC3 Expression in NALM6 Cells: 4.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>