NLRP12 [The Human Chemical-Genetic Interaction Map Project]

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======= NLRP12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NLRP12
  * **<color #00a2e8>Official Name</color>**: NLR family pyrin domain containing 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=91662|91662]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P59046|P59046]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NLRP12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NLRP12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609648|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PAAD DAPIN|
|NACHT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of Toll signaling pathway|
|regulation of interleukin-18 biosynthetic process|
|regulation of Toll signaling pathway|
|negative regulation of interleukin-6 biosynthetic process|
|positive regulation of MHC class I biosynthetic process|
|regulation of MHC class I biosynthetic process|
|regulation of interleukin-18 production|
|negative regulation of protein autophosphorylation|
|cysteine-type endopeptidase activator activity involved in apoptotic process|
|negative regulation of interleukin-1 secretion|
|dendritic cell migration|
|negative regulation of NIK/NF-kappaB signaling|
|regulation of interleukin-6 biosynthetic process|
|negative regulation of cytokine biosynthetic process|
|positive regulation of interleukin-1 beta secretion|
|negative regulation of interleukin-1 production|
|positive regulation of interleukin-1 secretion|
|negative regulation of I-kappaB kinase/NF-kappaB signaling|
|negative regulation of interleukin-6 production|
|regulation of interleukin-1 beta secretion|
|regulation of protein autophosphorylation|
|positive regulation of interleukin-1 beta production|
|regulation of interleukin-1 secretion|
|positive regulation of interleukin-1 production|
|negative regulation of ERK1 and ERK2 cascade|
|negative regulation of cytokine secretion|
|positive regulation of NIK/NF-kappaB signaling|
|regulation of interleukin-1 beta production|
|negative regulation of NF-kappaB transcription factor activity|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of interleukin-1 production|
|regulation of cytokine biosynthetic process|
|regulation of NIK/NF-kappaB signaling|
|negative regulation of protein secretion|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of inflammatory response|
|negative regulation of peptide secretion|
|positive regulation of inflammatory response|
|positive regulation of cytokine secretion|
|regulation of interleukin-6 production|
|positive regulation of cysteine-type endopeptidase activity|
|negative regulation of DNA-binding transcription factor activity|
|negative regulation of MAPK cascade|
|positive regulation of endopeptidase activity|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|positive regulation of peptidase activity|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|negative regulation of defense response|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of secretion|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of cysteine-type endopeptidase activity|
|positive regulation of protein secretion|
|negative regulation of cytokine production|
|positive regulation of peptide secretion|
|regulation of ERK1 and ERK2 cascade|
|regulation of inflammatory response|
|positive regulation of proteolysis|
|negative regulation of response to external stimulus|
|leukocyte migration|
|positive regulation of secretion by cell|
|negative regulation of protein phosphorylation|
|regulation of endopeptidase activity|
|positive regulation of protein transport|
|regulation of DNA-binding transcription factor activity|
|positive regulation of secretion|
|regulation of peptidase activity|
|negative regulation of phosphorylation|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|positive regulation of defense response|
|negative regulation of transport|
|regulation of peptide secretion|
|negative regulation of intracellular signal transduction|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|positive regulation of response to external stimulus|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of protein transport|
|regulation of proteolysis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|positive regulation of hydrolase activity|
|regulation of secretion|
|cell migration|
|positive regulation of transport|
|cellular response to cytokine stimulus|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|1.74|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15380
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NLRP12 Expression in NALM6 Cells: 2.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>