NLRP3 [The Human Chemical-Genetic Interaction Map Project]

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======= NLRP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NLRP3
  * **<color #00a2e8>Official Name</color>**: NLR family pyrin domain containing 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=114548|114548]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96P20|Q96P20]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NLRP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NLRP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606416|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PAAD DAPIN|
|NACHT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NLRP3 inflammasome complex assembly|
|interleukin-18 production|
|cytokine secretion involved in immune response|
|cellular response to peptidoglycan|
|positive regulation of T-helper 2 cell cytokine production|
|NLRP3 inflammasome complex|
|positive regulation of T-helper 2 cell differentiation|
|positive regulation of T-helper 17 cell differentiation|
|positive regulation of T-helper 17 type immune response|
|response to peptidoglycan|
|interleukin-1 secretion|
|regulation of T-helper 2 cell cytokine production|
|regulation of T-helper 2 cell differentiation|
|negative regulation of acute inflammatory response|
|positive regulation of interleukin-5 production|
|interleukin-1 beta production|
|positive regulation of interleukin-13 production|
|negative regulation of interleukin-1 beta secretion|
|interleukin-1 production|
|positive regulation of type 2 immune response|
|regulation of T-helper 17 cell differentiation|
|peptidoglycan binding|
|negative regulation of interleukin-1 secretion|
|positive regulation of T cell cytokine production|
|regulation of T-helper 17 type immune response|
|positive regulation of T-helper cell differentiation|
|regulation of interleukin-5 production|
|regulation of interleukin-13 production|
|cytokine production involved in immune response|
|negative regulation of NIK/NF-kappaB signaling|
|detection of biotic stimulus|
|positive regulation of interleukin-4 production|
|negative regulation of interleukin-1 beta production|
|regulation of interleukin-4 production|
|positive regulation of CD4-positive, alpha-beta T cell differentiation|
|regulation of type 2 immune response|
|regulation of T cell cytokine production|
|negative regulation of interleukin-1 production|
|positive regulation of interleukin-1 beta secretion|
|positive regulation of CD4-positive, alpha-beta T cell activation|
|regulation of T-helper cell differentiation|
|positive regulation of interleukin-1 secretion|
|regulation of acute inflammatory response|
|regulation of CD4-positive, alpha-beta T cell differentiation|
|positive regulation of alpha-beta T cell differentiation|
|regulation of interleukin-1 beta secretion|
|cytokine secretion|
|positive regulation of T cell mediated immunity|
|positive regulation of interleukin-1 beta production|
|positive regulation of cytokine production involved in immune response|
|regulation of interleukin-1 secretion|
|positive regulation of interleukin-1 production|
|regulation of CD4-positive, alpha-beta T cell activation|
|positive regulation of alpha-beta T cell activation|
|regulation of alpha-beta T cell differentiation|
|negative regulation of cytokine secretion|
|regulation of T cell mediated immunity|
|regulation of interleukin-1 beta production|
|positive regulation of T cell differentiation|
|negative regulation of NF-kappaB transcription factor activity|
|regulation of cytokine production involved in immune response|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of alpha-beta T cell activation|
|defense response to Gram-positive bacterium|
|positive regulation of lymphocyte differentiation|
|regulation of interleukin-1 production|
|positive regulation of production of molecular mediator of immune response|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of adaptive immune response|
|regulation of NIK/NF-kappaB signaling|
|negative regulation of protein secretion|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of leukocyte mediated immunity|
|negative regulation of inflammatory response|
|regulation of T cell differentiation|
|negative regulation of peptide secretion|
|positive regulation of cytokine secretion|
|regulation of production of molecular mediator of immune response|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of leukocyte differentiation|
|cytokine production|
|regulation of lymphocyte mediated immunity|
|positive regulation of cysteine-type endopeptidase activity|
|positive regulation of NF-kappaB transcription factor activity|
|protein secretion|
|establishment of protein localization to extracellular region|
|negative regulation of DNA-binding transcription factor activity|
|regulation of adaptive immune response|
|protein localization to extracellular region|
|regulation of lymphocyte differentiation|
|positive regulation of endopeptidase activity|
|peptide secretion|
|production of molecular mediator of immune response|
|negative regulation of protein transport|
|cellular response to lipopolysaccharide|
|negative regulation of establishment of protein localization|
|positive regulation of hemopoiesis|
|defense response to virus|
|positive regulation of peptidase activity|
|cellular response to molecule of bacterial origin|
|positive regulation of T cell activation|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|regulation of leukocyte mediated immunity|
|negative regulation of defense response|
|cellular response to biotic stimulus|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|negative regulation of secretion|
|regulation of cysteine-type endopeptidase activity|
|positive regulation of cell-cell adhesion|
|positive regulation of DNA-binding transcription factor activity|
|positive regulation of protein secretion|
|regulation of leukocyte differentiation|
|negative regulation of cytokine production|
|response to virus|
|protein deubiquitination|
|positive regulation of peptide secretion|
|regulation of leukocyte cell-cell adhesion|
|protein modification by small protein removal|
|response to lipopolysaccharide|
|regulation of T cell activation|
|response to molecule of bacterial origin|
|defense response to bacterium|
|transcription factor binding|
|regulation of inflammatory response|
|positive regulation of proteolysis|
|positive regulation of lymphocyte activation|
|negative regulation of response to external stimulus|
|regulation of cell-cell adhesion|
|positive regulation of secretion by cell|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|regulation of endopeptidase activity|
|sequence-specific DNA binding|
|positive regulation of protein transport|
|regulation of DNA-binding transcription factor activity|
|positive regulation of secretion|
|regulation of peptidase activity|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|negative regulation of transport|
|regulation of peptide secretion|
|inflammatory response|
|negative regulation of intracellular signal transduction|
|regulation of lymphocyte activation|
|protein complex oligomerization|
|cellular response to lipid|
|cellular response to organonitrogen compound|
|regulation of leukocyte activation|
|Golgi membrane|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|cellular response to nitrogen compound|
|regulation of cell adhesion|
|response to bacterium|
|detection of stimulus|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of protein transport|
|regulation of proteolysis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|innate immune response|
|positive regulation of hydrolase activity|
|regulation of secretion|
|cellular protein-containing complex assembly|
|response to lipid|
|positive regulation of immune response|
|apoptotic process|
|defense response to other organism|
|positive regulation of cell differentiation|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|response to organonitrogen compound|
|secretion by cell|
|endoplasmic reticulum|
|regulation of protein localization|
|export from cell|
|programmed cell death|
|cellular response to oxygen-containing compound|
|identical protein binding|
|response to nitrogen compound|
|cell death|
|immune effector process|
|regulation of response to external stimulus|
|secretion|
|negative regulation of molecular function|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|proteolysis|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|protein transport|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|amide transport|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11069
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NLRP3 Expression in NALM6 Cells: 1.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>