NLRP7 [The Human Chemical-Genetic Interaction Map Project]

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======= NLRP7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NLRP7
  * **<color #00a2e8>Official Name</color>**: NLR family pyrin domain containing 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=199713|199713]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WX94|Q8WX94]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NLRP7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NLRP7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609661|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibits CASP1/caspase-1-dependent IL1B secretion. {ECO:0000269|PubMed:15817483}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PAAD DAPIN|
|NACHT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of aspartic-type peptidase activity|
|aspartic-type endopeptidase inhibitor activity|
|interleukin-1 binding|
|regulation of aspartic-type peptidase activity|
|caspase binding|
|negative regulation of interleukin-1 beta secretion|
|negative regulation of cytokine production involved in inflammatory response|
|negative regulation of interleukin-1 secretion|
|negative regulation of interleukin-1 beta production|
|positive regulation of interleukin-1 beta secretion|
|negative regulation of protein processing|
|negative regulation of protein maturation|
|negative regulation of interleukin-1 production|
|positive regulation of interleukin-1 secretion|
|regulation of cytokine production involved in inflammatory response|
|regulation of interleukin-1 beta secretion|
|positive regulation of interleukin-1 beta production|
|regulation of interleukin-1 secretion|
|positive regulation of interleukin-1 production|
|regulation of protein processing|
|negative regulation of cytokine secretion|
|regulation of protein maturation|
|regulation of interleukin-1 beta production|
|regulation of interleukin-1 production|
|negative regulation of protein secretion|
|negative regulation of inflammatory response|
|negative regulation of peptide secretion|
|positive regulation of cytokine secretion|
|cellular response to interleukin-1|
|negative regulation of protein transport|
|cellular response to lipopolysaccharide|
|negative regulation of establishment of protein localization|
|cellular response to molecule of bacterial origin|
|response to interleukin-1|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|negative regulation of defense response|
|cellular response to biotic stimulus|
|negative regulation of secretion|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|positive regulation of protein secretion|
|negative regulation of cytokine production|
|positive regulation of peptide secretion|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|regulation of inflammatory response|
|negative regulation of proteolysis|
|negative regulation of response to external stimulus|
|positive regulation of secretion by cell|
|regulation of endopeptidase activity|
|positive regulation of protein transport|
|positive regulation of secretion|
|regulation of peptidase activity|
|positive regulation of cytokine production|
|cellular component|
|negative regulation of hydrolase activity|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|negative regulation of transport|
|regulation of peptide secretion|
|cellular response to lipid|
|response to bacterium|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of proteolysis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|negative regulation of catalytic activity|
|regulation of secretion|
|response to lipid|
|positive regulation of transport|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|regulation of response to stress|
|ATP binding|
|response to oxygen-containing compound|
|negative regulation of response to stimulus|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|1.75|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|1.84|
|[[:results:exp302|35°C R06 exp302]]|2.1|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3532
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NLRP7 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>