NME2 [The Human Chemical-Genetic Interaction Map Project]

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======= NME2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NME2
  * **<color #00a2e8>Official Name</color>**: NME/NM23 nucleoside diphosphate kinase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4831|4831]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P22392|P22392]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NME2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NME2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/156491|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity. {ECO:0000269|PubMed:15249197, ECO:0000269|PubMed:20946858, ECO:0000269|PubMed:8392752}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NDK|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein histidine kinase activity|
|peptidyl-histidine phosphorylation|
|G-quadruplex DNA binding|
|UTP biosynthetic process|
|intermediate filament binding|
|peptidyl-histidine modification|
|GTP biosynthetic process|
|UTP metabolic process|
|CTP metabolic process|
|guanosine-containing compound biosynthetic process|
|CTP biosynthetic process|
|pyrimidine ribonucleoside triphosphate biosynthetic process|
|positive regulation of keratinocyte differentiation|
|pyrimidine ribonucleoside triphosphate metabolic process|
|nucleoside diphosphate kinase activity|
|pyrimidine nucleoside triphosphate biosynthetic process|
|pyrimidine ribonucleotide biosynthetic process|
|ribonucleoside biosynthetic process|
|purine ribonucleoside biosynthetic process|
|pyrimidine nucleoside triphosphate metabolic process|
|purine nucleoside biosynthetic process|
|fatty acid binding|
|pyrimidine ribonucleotide metabolic process|
|positive regulation of epidermal cell differentiation|
|GTP metabolic process|
|nucleobase-containing small molecule interconversion|
|response to growth hormone|
|cell periphery|
|positive regulation of epidermis development|
|nucleoside biosynthetic process|
|guanosine-containing compound metabolic process|
|regulation of keratinocyte differentiation|
|glycosyl compound biosynthetic process|
|purine ribonucleoside triphosphate biosynthetic process|
|purine nucleoside triphosphate biosynthetic process|
|negative regulation of myeloid leukocyte differentiation|
|pyrimidine nucleotide biosynthetic process|
|ribonucleoside triphosphate biosynthetic process|
|cellular response to fatty acid|
|pyrimidine-containing compound biosynthetic process|
|positive regulation of epithelial cell differentiation|
|purine ribonucleoside triphosphate metabolic process|
|nucleoside diphosphate phosphorylation|
|purine ribonucleoside metabolic process|
|regulation of epidermal cell differentiation|
|nucleotide phosphorylation|
|pyrimidine nucleotide metabolic process|
|nucleoside triphosphate biosynthetic process|
|purine nucleoside metabolic process|
|ribonucleoside triphosphate metabolic process|
|purine nucleoside triphosphate metabolic process|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|cellular response to monosaccharide stimulus|
|GDP binding|
|ribonucleoside metabolic process|
|negative regulation of myeloid cell differentiation|
|cellular response to carbohydrate stimulus|
|nucleoside diphosphate metabolic process|
|response to fatty acid|
|regulation of epidermis development|
|cellular glucose homeostasis|
|nucleoside triphosphate metabolic process|
|ruffle|
|integrin-mediated signaling pathway|
|negative regulation of leukocyte differentiation|
|mitochondrial membrane|
|pyrimidine-containing compound metabolic process|
|nucleobase-containing small molecule biosynthetic process|
|nucleoside metabolic process|
|regulation of myeloid leukocyte differentiation|
|secretory granule lumen|
|intermediate filament|
|ficolin-1-rich granule lumen|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|glycosyl compound metabolic process|
|negative regulation of hemopoiesis|
|response to glucose|
|regulation of epithelial cell differentiation|
|response to hexose|
|cAMP-mediated signaling|
|response to monosaccharide|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|response to carbohydrate|
|cyclic-nucleotide-mediated signaling|
|lamellipodium|
|glucose homeostasis|
|carbohydrate homeostasis|
|positive regulation of epithelial cell proliferation|
|protein autophosphorylation|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|cellular response to acid chemical|
|regulation of myeloid cell differentiation|
|cellular response to oxidative stress|
|nucleotide biosynthetic process|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|nucleoside phosphate biosynthetic process|
|regulation of leukocyte differentiation|
|positive regulation of neuron projection development|
|transcription coactivator activity|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|regulation of epithelial cell proliferation|
|ribose phosphate metabolic process|
|second-messenger-mediated signaling|
|response to acid chemical|
|enzyme binding|
|protein serine/threonine kinase activity|
|purine-containing compound metabolic process|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|response to oxidative stress|
|response to peptide hormone|
|focal adhesion|
|negative regulation of immune system process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|regulation of hemopoiesis|
|positive regulation of neurogenesis|
|response to peptide|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|regulation of neuron projection development|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|protein complex oligomerization|
|cellular response to lipid|
|myeloid cell activation involved in immune response|
|positive regulation of nervous system development|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|positive regulation of cell development|
|myeloid leukocyte activation|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|regulated exocytosis|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|cellular chemical homeostasis|
|leukocyte mediated immunity|
|exocytosis|
|regulation of neurogenesis|
|response to lipid|
|peptidyl-amino acid modification|
|organophosphate metabolic process|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|response to hormone|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|leukocyte activation|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|protein phosphorylation|
|negative regulation of cell death|
|response to organonitrogen compound|
|secretion by cell|
|carbohydrate derivative metabolic process|
|export from cell|
|cellular response to oxygen-containing compound|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|nucleobase-containing compound biosynthetic process|
|chemical homeostasis|
|secretion|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|G protein-coupled receptor signaling pathway|
|positive regulation of developmental process|
|organonitrogen compound biosynthetic process|
|DNA binding|
|response to endogenous stimulus|
|ATP binding|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15125
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NME2 Expression in NALM6 Cells: 6.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>