NME5 [The Human Chemical-Genetic Interaction Map Project]

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======= NME5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NME5
  * **<color #00a2e8>Official Name</color>**: NME/NM23 family member 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8382|8382]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P56597|P56597]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NME5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NME5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603575|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NDK|
|Dpy-30|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|UTP biosynthetic process|
|GTP biosynthetic process|
|UTP metabolic process|
|CTP metabolic process|
|guanosine-containing compound biosynthetic process|
|CTP biosynthetic process|
|pyrimidine ribonucleoside triphosphate biosynthetic process|
|pyrimidine ribonucleoside triphosphate metabolic process|
|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|pyrimidine nucleoside triphosphate biosynthetic process|
|nucleoside diphosphate kinase activity|
|pyrimidine ribonucleotide biosynthetic process|
|ribonucleoside biosynthetic process|
|purine ribonucleoside biosynthetic process|
|pyrimidine nucleoside triphosphate metabolic process|
|purine nucleoside biosynthetic process|
|pyrimidine ribonucleotide metabolic process|
|GTP metabolic process|
|ventricular system development|
|epithelial cilium movement involved in extracellular fluid movement|
|regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|extracellular transport|
|nucleoside biosynthetic process|
|guanosine-containing compound metabolic process|
|glycosyl compound biosynthetic process|
|sperm flagellum|
|negative regulation of oxidative stress-induced cell death|
|purine ribonucleoside triphosphate biosynthetic process|
|negative regulation of cellular response to oxidative stress|
|purine nucleoside triphosphate biosynthetic process|
|pyrimidine nucleotide biosynthetic process|
|negative regulation of response to oxidative stress|
|ribonucleoside triphosphate biosynthetic process|
|pyrimidine-containing compound biosynthetic process|
|purine ribonucleoside triphosphate metabolic process|
|cilium movement|
|nucleoside diphosphate phosphorylation|
|purine ribonucleoside metabolic process|
|nucleotide phosphorylation|
|pyrimidine nucleotide metabolic process|
|nucleoside triphosphate biosynthetic process|
|regulation of oxidative stress-induced cell death|
|purine nucleoside metabolic process|
|ribonucleoside triphosphate metabolic process|
|purine nucleoside triphosphate metabolic process|
|regulation of cellular response to oxidative stress|
|ribonucleoside metabolic process|
|nucleoside diphosphate metabolic process|
|regulation of response to oxidative stress|
|nucleoside triphosphate metabolic process|
|negative regulation of intrinsic apoptotic signaling pathway|
|pyrimidine-containing compound metabolic process|
|nucleobase-containing small molecule biosynthetic process|
|nucleoside metabolic process|
|glycosyl compound metabolic process|
|purine ribonucleotide biosynthetic process|
|spermatid development|
|purine nucleotide biosynthetic process|
|spermatid differentiation|
|regulation of intrinsic apoptotic signaling pathway|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|microtubule-based transport|
|negative regulation of apoptotic signaling pathway|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|germ cell development|
|microtubule-based movement|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|cilium assembly|
|cellular process involved in reproduction in multicellular organism|
|purine-containing compound metabolic process|
|cilium organization|
|regulation of apoptotic signaling pathway|
|nucleotide metabolic process|
|plasma membrane bounded cell projection assembly|
|cellular component|
|nucleoside phosphate metabolic process|
|cell projection assembly|
|negative regulation of intracellular signal transduction|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|spermatogenesis|
|male gamete generation|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|developmental process involved in reproduction|
|microtubule-based process|
|gamete generation|
|regulation of cellular response to stress|
|brain development|
|organelle assembly|
|head development|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|organophosphate metabolic process|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|central nervous system development|
|negative regulation of cell death|
|multi-organism reproductive process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of signal transduction|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|regulation of response to stress|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|cell development|
|regulation of cell death|
|small molecule metabolic process|
|regulation of intracellular signal transduction|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-2.02|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16253
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.72 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NME5 Expression in NALM6 Cells: -1.72'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>