NOC4L [The Human Chemical-Genetic Interaction Map Project]

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======= NOC4L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOC4L
  * **<color #00a2e8>Official Name</color>**: nucleolar complex associated 4 homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79050|79050]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BVI4|Q9BVI4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOC4L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOC4L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612819|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CBF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Noc4p-Nop14p complex|
|small-subunit processome|
|rRNA processing|
|rRNA metabolic process|
|nuclear membrane|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|nucleolus|
|RNA processing|
|RNA binding|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.94|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.87|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.71|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.463|
|[[:human genes:r:rps5|RPS5]]|0.444|
|[[:human genes:n:nob1|NOB1]]|0.423|
|[[:human genes:i:ik|IK]]|0.419|
|[[:human genes:r:rps3a|RPS3A]]|0.416|
|[[:human genes:r:rrp7a|RRP7A]]|0.413|
|[[:human genes:c:chd4|CHD4]]|0.412|
|[[:human genes:e:exosc1|EXOSC1]]|0.407|
|[[:human genes:l:lrr1|LRR1]]|0.407|
|[[:human genes:a:aatf|AATF]]|0.405|
|[[:human genes:r:rps19|RPS19]]|0.404|
|[[:human genes:p:prim1|PRIM1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 646/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|26/28|
|blood|21/28|
|bone|23/26|
|breast|24/33|
|central nervous system|55/56|
|cervix|3/4|
|colorectal|15/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|14/16|
|kidney|17/21|
|liver|17/20|
|lung|65/75|
|lymphocyte|14/16|
|ovary|23/26|
|pancreas|24/24|
|peripheral nervous system|14/16|
|plasma cell|11/15|
|prostate|0/1|
|skin|22/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|19/22|
|urinary tract|27/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 903
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOC4L Expression in NALM6 Cells: 4.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>