NODAL [The Human Chemical-Genetic Interaction Map Project]

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======= NODAL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NODAL
  * **<color #00a2e8>Official Name</color>**: nodal growth differentiation factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4838|4838]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96S42|Q96S42]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NODAL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NODAL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601265|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which regulates early embryonic development. This protein is required for maintenance of human embryonic stem cell pluripotency and may play a role in human placental development. Mutations in this gene are associated with heterotaxy, a condition characterized by random orientation of visceral organs with respect to the left-right axis. [provided by RefSeq, Aug 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Essential for mesoderm formation and axial patterning during embryonic development. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TGFb propeptide|
|TGF beta|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|polarity specification of proximal/distal axis|
|axial mesodermal cell fate commitment|
|axial mesodermal cell fate specification|
|epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification|
|transforming growth factor beta receptor signaling pathway involved in primitive streak formation|
|left lung morphogenesis|
|axial mesodermal cell differentiation|
|left lung development|
|floor plate morphogenesis|
|axial mesoderm formation|
|type I activin receptor binding|
|trophectodermal cellular morphogenesis|
|positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry|
|negative regulation of chorionic trophoblast cell proliferation|
|axial mesoderm morphogenesis|
|proximal/distal axis specification|
|nodal signaling pathway involved in determination of left/right asymmetry|
|nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry|
|regulation of transcription from RNA polymerase II promoter involved in determination of left/right symmetry|
|specification of axis polarity|
|regulation of chorionic trophoblast cell proliferation|
|positive regulation of mesoderm development|
|regulation of nodal signaling pathway involved in determination of left/right asymmetry|
|regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry|
|formation of anatomical boundary|
|inhibition of neuroepithelial cell differentiation|
|negative regulation of trophoblast cell migration|
|determination of left/right asymmetry in lateral mesoderm|
|embryonic process involved in female pregnancy|
|morphogen activity|
|neural fold formation|
|axial mesoderm development|
|maternal process involved in parturition|
|mesodermal cell fate specification|
|floor plate development|
|regulation of nodal signaling pathway|
|positive regulation of activin receptor signaling pathway|
|mesendoderm development|
|primitive streak formation|
|regulation of trophoblast cell migration|
|nodal signaling pathway|
|lateral mesoderm development|
|positive regulation of SMAD protein signal transduction|
|regulation of timing of cell differentiation|
|mesodermal cell fate commitment|
|regulation of development, heterochronic|
|negative regulation of androgen receptor signaling pathway|
|trophectodermal cell differentiation|
|cell migration involved in gastrulation|
|parturition|
|regulation of mesoderm development|
|morphogenesis of an epithelial fold|
|regulation of SMAD protein signal transduction|
|regulation of activin receptor signaling pathway|
|activin receptor signaling pathway|
|regulation of androgen receptor signaling pathway|
|mesodermal cell differentiation|
|regulation of stem cell population maintenance|
|cell fate commitment involved in formation of primary germ layer|
|positive regulation of vascular endothelial growth factor production|
|gastrulation with mouth forming second|
|proximal/distal pattern formation|
|regulation of vascular endothelial growth factor production|
|maternal placenta development|
|negative regulation of intracellular steroid hormone receptor signaling pathway|
|regulation of gastrulation|
|blastocyst formation|
|negative regulation of epithelial cell differentiation|
|endodermal cell differentiation|
|transforming growth factor beta receptor binding|
|lung morphogenesis|
|embryonic cranial skeleton morphogenesis|
|endoderm formation|
|positive regulation of pathway-restricted SMAD protein phosphorylation|
|digestive tract morphogenesis|
|anterior/posterior axis specification|
|SMAD protein signal transduction|
|negative regulation of reproductive process|
|heart looping|
|regulation of pathway-restricted SMAD protein phosphorylation|
|embryonic pattern specification|
|maternal process involved in female pregnancy|
|determination of heart left/right asymmetry|
|embryonic heart tube morphogenesis|
|cranial skeletal system development|
|mesoderm formation|
|mesoderm morphogenesis|
|endoderm development|
|embryonic heart tube development|
|regulation of intracellular steroid hormone receptor signaling pathway|
|axis specification|
|embryonic placenta development|
|cell fate specification|
|BMP signaling pathway|
|embryonic skeletal system morphogenesis|
|primary neural tube formation|
|blastocyst development|
|transforming growth factor beta receptor signaling pathway|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|cellular response to BMP stimulus|
|response to BMP|
|neural tube formation|
|formation of primary germ layer|
|determination of left/right symmetry|
|embryonic epithelial tube formation|
|determination of bilateral symmetry|
|specification of symmetry|
|mesoderm development|
|liver development|
|embryonic skeletal system development|
|regulation of embryonic development|
|hepaticobiliary system development|
|digestive tract development|
|epithelial tube formation|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|stem cell population maintenance|
|maintenance of cell number|
|regulation of epithelial cell differentiation|
|digestive system development|
|morphogenesis of embryonic epithelium|
|tube formation|
|positive regulation of cysteine-type endopeptidase activity|
|placenta development|
|cellular response to transforming growth factor beta stimulus|
|gastrulation|
|neural tube development|
|regulation of reproductive process|
|response to transforming growth factor beta|
|growth factor activity|
|positive regulation of angiogenesis|
|lung development|
|ameboidal-type cell migration|
|positive regulation of endopeptidase activity|
|respiratory tube development|
|cytokine activity|
|female pregnancy|
|positive regulation of vasculature development|
|positive regulation of epithelial cell proliferation|
|positive regulation of peptidase activity|
|respiratory system development|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|multi-multicellular organism process|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of multi-organism process|
|anterior/posterior pattern specification|
|mesenchyme development|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|skeletal system morphogenesis|
|regulation of cysteine-type endopeptidase activity|
|cell fate commitment|
|heart morphogenesis|
|positive regulation of cell-cell adhesion|
|negative regulation of cell migration|
|positive regulation of DNA-binding transcription factor activity|
|negative regulation of cell motility|
|regulation of angiogenesis|
|embryonic organ morphogenesis|
|regulation of ERK1 and ERK2 cascade|
|epithelial tube morphogenesis|
|negative regulation of cellular component movement|
|regulation of vasculature development|
|negative regulation of locomotion|
|regionalization|
|regulation of epithelial cell proliferation|
|negative regulation of cell development|
|positive regulation of proteolysis|
|in utero embryonic development|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|gland development|
|regulation of endopeptidase activity|
|reproductive structure development|
|regulation of DNA-binding transcription factor activity|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|regulation of peptidase activity|
|positive regulation of cytokine production|
|skeletal system development|
|cellular response to growth factor stimulus|
|vasculature development|
|cardiovascular system development|
|heart development|
|response to growth factor|
|positive regulation of MAPK cascade|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of cytokine production|
|positive regulation of cell death|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of proteolysis|
|brain development|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|head development|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|tube development|
|regulation of cell migration|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|cell migration|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|multi-organism reproductive process|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|epithelium development|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|locomotion|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14593
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NODAL Expression in NALM6 Cells: -0.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>