NOL8 [The Human Chemical-Genetic Interaction Map Project]

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======= NOL8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOL8
  * **<color #00a2e8>Official Name</color>**: nucleolar protein 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55035|55035]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q76FK4|Q76FK4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOL8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOL8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611534|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to nucleolus|
|ribonucleoprotein complex|
|protein localization to nucleus|
|rRNA processing|
|rRNA metabolic process|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|protein localization to organelle|
|nucleolus|
|RNA processing|
|RNA binding|
|cellular protein localization|
|cellular macromolecule localization|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.82|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|1.91|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|1.97|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:ddt|DDT]]|0.514|
|[[:human genes:n:nupl1|NUPL1]]|0.485|
|[[:human genes:d:ddtl|DDTL]]|0.478|
|[[:human genes:t:ticrr|TICRR]]|0.453|
|[[:human genes:z:znf830|ZNF830]]|0.449|
|[[:human genes:p:psma6|PSMA6]]|0.446|
|[[:human genes:t:twistnb|TWISTNB]]|0.445|
|[[:human genes:p:psmd1|PSMD1]]|0.44|
|[[:human genes:o:or10g3|OR10G3]]|0.439|
|[[:human genes:h:hap1|HAP1]]|0.436|
|[[:human genes:m:mt1e|MT1E]]|0.435|
|[[:human genes:c:copa|COPA]]|0.434|
|[[:human genes:c:chd4|CHD4]]|0.434|
|[[:human genes:p:psmb4|PSMB4]]|0.431|
|[[:human genes:s:ssh2|SSH2]]|0.431|
|[[:human genes:p:psmc6|PSMC6]]|0.428|
|[[:human genes:s:syt9|SYT9]]|0.428|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.427|
|[[:human genes:g:gid4|GID4]]|0.425|
|[[:human genes:c:copb1|COPB1]]|0.425|
|[[:human genes:t:tfip11|TFIP11]]|0.42|
|[[:human genes:c:cactin|CACTIN]]|0.419|
|[[:human genes:a:ankle2|ANKLE2]]|0.418|
|[[:human genes:t:tceb3c|TCEB3C]]|0.415|
|[[:human genes:p:psmd11|PSMD11]]|0.414|
|[[:human genes:l:lrr1|LRR1]]|0.41|
|[[:human genes:r:rrp15|RRP15]]|0.408|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.407|
|[[:human genes:x:xylt2|XYLT2]]|0.406|
|[[:human genes:p:polr2f|POLR2F]]|0.404|
|[[:human genes:m:med14|MED14]]|0.402|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 111/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|5/28|
|bone|4/26|
|breast|3/33|
|central nervous system|6/56|
|cervix|0/4|
|colorectal|3/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|3/21|
|liver|6/20|
|lung|14/75|
|lymphocyte|2/16|
|ovary|7/26|
|pancreas|2/24|
|peripheral nervous system|2/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|8/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1770
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOL8 Expression in NALM6 Cells: 7.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>