NOTCH1 [The Human Chemical-Genetic Interaction Map Project]

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======= NOTCH1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOTCH1
  * **<color #00a2e8>Official Name</color>**: notch receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4851|4851]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P46531|P46531]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOTCH1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOTCH1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/190198|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. [provided by RefSeq, Jan 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). {ECO:0000269|PubMed:20616313}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank 2|
|Ank|
|EGF|
|NOD|
|DUF3454|
|EGF CA|
|NODP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|venous endothelial cell differentiation|
|coronary sinus valve morphogenesis|
|coronary sinus valve development|
|Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation|
|negative regulation of cell proliferation involved in heart valve morphogenesis|
|regulation of aorta morphogenesis|
|cardiac right atrium morphogenesis|
|coronary vein morphogenesis|
|positive regulation of aorta morphogenesis|
|cardiac vascular smooth muscle cell development|
|atrioventricular node development|
|apoptotic process involved in embryonic digit morphogenesis|
|negative regulation of growth rate|
|negative regulation of lymphoid progenitor cell differentiation|
|negative regulation of pro-B cell differentiation|
|MAML1-RBP-Jkappa- ICN1 complex|
|negative regulation of cell proliferation involved in heart morphogenesis|
|mitral valve formation|
|regulation of cell proliferation involved in heart valve morphogenesis|
|inner ear receptor cell fate commitment|
|negative regulation of inner ear receptor cell differentiation|
|negative regulation of mechanoreceptor differentiation|
|positive regulation of artery morphogenesis|
|cell migration involved in endocardial cushion formation|
|regulation of artery morphogenesis|
|growth involved in heart morphogenesis|
|negative regulation of inner ear auditory receptor cell differentiation|
|auditory receptor cell fate commitment|
|negative regulation of extracellular matrix constituent secretion|
|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development|
|cardiac right ventricle formation|
|negative regulation of endothelial cell chemotaxis|
|vasculogenesis involved in coronary vascular morphogenesis|
|positive regulation of apoptotic process involved in development|
|glomerular mesangial cell development|
|compartment pattern specification|
|inhibition of neuroepithelial cell differentiation|
|positive regulation of apoptotic process involved in morphogenesis|
|endocardium morphogenesis|
|cardiac vascular smooth muscle cell differentiation|
|mesangial cell development|
|interleukin-4 secretion|
|positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|
|arterial endothelial cell differentiation|
|glomerular mesangial cell differentiation|
|interleukin-4 production|
|mesangial cell differentiation|
|regulation of pro-B cell differentiation|
|regulation of growth rate|
|regulation of extracellular matrix constituent secretion|
|regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|
|regulation of somitogenesis|
|regulation of lymphoid progenitor cell differentiation|
|cardiac endothelial cell differentiation|
|negative regulation of hematopoietic progenitor cell differentiation|
|glomerular mesangium development|
|blood vessel endothelial cell differentiation|
|atrioventricular valve formation|
|regulation of mechanoreceptor differentiation|
|regulation of inner ear receptor cell differentiation|
|pericyte cell differentiation|
|positive regulation of cardiac epithelial to mesenchymal transition|
|endocardial cell differentiation|
|regulation of inner ear auditory receptor cell differentiation|
|negative regulation of photoreceptor cell differentiation|
|pericardium morphogenesis|
|vascular smooth muscle cell development|
|regulation of extracellular matrix assembly|
|regulation of secondary heart field cardioblast proliferation|
|regulation of photoreceptor cell differentiation|
|coronary artery morphogenesis|
|venous blood vessel morphogenesis|
|negative regulation of calcium ion-dependent exocytosis|
|cardiac ventricle formation|
|regulation of epithelial cell proliferation involved in prostate gland development|
|foregut morphogenesis|
|regulation of cardioblast proliferation|
|mitral valve morphogenesis|
|cardiac muscle cell myoblast differentiation|
|regulation of cardiac epithelial to mesenchymal transition|
|prostate glandular acinus development|
|Notch signaling involved in heart development|
|cardiac chamber formation|
|cellular response to follicle-stimulating hormone stimulus|
|negative regulation of extracellular matrix organization|
|mitral valve development|
|distal tubule development|
|positive regulation of astrocyte differentiation|
|regulation of apoptotic process involved in morphogenesis|
|cardiac conduction system development|
|regulation of apoptotic process involved in development|
|epithelial cell differentiation involved in prostate gland development|
|collecting duct development|
|endocardium development|
|negative regulation of oligodendrocyte differentiation|
|regulation of timing of cell differentiation|
|epithelial to mesenchymal transition involved in endocardial cushion formation|
|heart valve formation|
|left/right axis specification|
|cardioblast differentiation|
|cell migration involved in heart development|
|epithelial cell fate commitment|
|negative regulation of epidermal cell differentiation|
|negative regulation of glial cell proliferation|
|regulation of transcription from RNA polymerase II promoter involved in heart development|
|cardiac muscle cell proliferation|
|cardiac left ventricle morphogenesis|
|vascular smooth muscle cell differentiation|
|regulation of development, heterochronic|
|negative regulation of cell migration involved in sprouting angiogenesis|
|striated muscle cell proliferation|
|venous blood vessel development|
|positive regulation of endothelial cell differentiation|
|apoptotic process involved in morphogenesis|
|coronary vasculature morphogenesis|
|ventricular trabecula myocardium morphogenesis|
|positive regulation of keratinocyte differentiation|
|response to follicle-stimulating hormone|
|regulation of cell proliferation involved in heart morphogenesis|
|negative regulation of anoikis|
|pulmonary valve morphogenesis|
|muscle cell proliferation|
|negative regulation of epidermis development|
|positive regulation of transcription of Notch receptor target|
|cellular response to gonadotropin stimulus|
|glomerulus vasculature development|
|negative regulation of myotube differentiation|
|pericardium development|
|kidney vasculature development|
|endocardial cushion formation|
|renal system vasculature development|
|response to muramyl dipeptide|
|cardiac right ventricle morphogenesis|
|negative regulation of stem cell differentiation|
|pulmonary valve development|
|left/right pattern formation|
|regulation of endothelial cell chemotaxis|
|prostate gland epithelium morphogenesis|
|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|
|positive regulation of neuroblast proliferation|
|somatic stem cell division|
|neuronal stem cell population maintenance|
|atrioventricular valve morphogenesis|
|cell surface receptor signaling pathway involved in heart development|
|inflammatory response to antigenic stimulus|
|positive regulation of epidermal cell differentiation|
|regulation of anoikis|
|negative regulation of sprouting angiogenesis|
|prostate gland morphogenesis|
|negative regulation of glial cell differentiation|
|negative regulation of myoblast differentiation|
|negative regulation of regulated secretory pathway|
|hair follicle morphogenesis|
|positive regulation of cardiac muscle cell proliferation|
|inner ear auditory receptor cell differentiation|
|atrioventricular valve development|
|negative regulation of cardiac muscle hypertrophy|
|Notch binding|
|cardiac muscle tissue growth|
|apoptotic process involved in development|
|regulation of astrocyte differentiation|
|aortic valve morphogenesis|
|cardiac epithelial to mesenchymal transition|
|response to gonadotropin|
|negative regulation of biomineralization|
|negative regulation of muscle hypertrophy|
|embryonic hindlimb morphogenesis|
|heart growth|
|negative regulation of biomineral tissue development|
|epidermis morphogenesis|
|homeostasis of number of cells within a tissue|
|regulation of glial cell proliferation|
|epithelial cell differentiation involved in kidney development|
|cardiac atrium morphogenesis|
|positive regulation of transcription from RNA polymerase II promoter in response to stress|
|enzyme inhibitor activity|
|aortic valve development|
|negative regulation of blood vessel endothelial cell migration|
|heart trabecula morphogenesis|
|regulation of neuroblast proliferation|
|smooth muscle cell differentiation|
|positive regulation of BMP signaling pathway|
|regulation of endothelial cell differentiation|
|positive regulation of cardiac muscle tissue growth|
|stem cell division|
|negative regulation of animal organ morphogenesis|
|negative regulation of exocytosis|
|hair cell differentiation|
|positive regulation of viral genome replication|
|endocardial cushion morphogenesis|
|cardiac atrium development|
|myoblast differentiation|
|hindlimb morphogenesis|
|regulation of animal organ formation|
|positive regulation of heart growth|
|semi-lunar valve development|
|regulation of cell migration involved in sprouting angiogenesis|
|negative regulation of striated muscle cell differentiation|
|regulation of extracellular matrix organization|
|glandular epithelial cell differentiation|
|positive regulation of stem cell proliferation|
|regulation of oligodendrocyte differentiation|
|positive regulation of epidermis development|
|regulation of cardiac muscle cell proliferation|
|cellular response to vascular endothelial growth factor stimulus|
|regulation of heart morphogenesis|
|cell differentiation involved in kidney development|
|negative regulation of gliogenesis|
|negative regulation of epithelial cell differentiation|
|prostate gland development|
|regulation of keratinocyte differentiation|
|ventricular septum morphogenesis|
|positive regulation of glial cell differentiation|
|regulation of calcium ion-dependent exocytosis|
|negative regulation of osteoblast differentiation|
|endocardial cushion development|
|positive regulation of cardiac muscle tissue development|
|neuroepithelial cell differentiation|
|coronary vasculature development|
|trabecula morphogenesis|
|positive regulation of epithelial to mesenchymal transition|
|negative regulation of cold-induced thermogenesis|
|positive regulation of organ growth|
|cytokine secretion|
|ventricular cardiac muscle tissue morphogenesis|
|digestive tract morphogenesis|
|morphogenesis of an epithelial sheet|
|negative regulation of endothelial cell migration|
|negative regulation of BMP signaling pathway|
|mesenchyme morphogenesis|
|skeletal muscle cell differentiation|
|glomerulus development|
|heart valve morphogenesis|
|inner ear receptor cell differentiation|
|positive regulation of neural precursor cell proliferation|
|positive regulation of Notch signaling pathway|
|regulation of myoblast differentiation|
|astrocyte differentiation|
|cell differentiation in spinal cord|
|ventricular cardiac muscle tissue development|
|negative regulation of muscle cell differentiation|
|regulation of cardiac muscle hypertrophy|
|sprouting angiogenesis|
|negative regulation of chemotaxis|
|mechanoreceptor differentiation|
|regulation of myotube differentiation|
|regulation of cardiac muscle tissue growth|
|regulation of muscle hypertrophy|
|positive regulation of epithelial cell differentiation|
|heart looping|
|heart valve development|
|positive regulation of viral life cycle|
|embryonic digit morphogenesis|
|regulation of epidermal cell differentiation|
|artery morphogenesis|
|negative regulation of cell-substrate adhesion|
|tissue regeneration|
|adherens junction|
|positive regulation of Ras protein signal transduction|
|regulation of heart growth|
|neuron fate commitment|
|cardiac cell development|
|regulation of stem cell proliferation|
|embryonic heart tube morphogenesis|
|negative regulation of epithelial cell migration|
|determination of heart left/right asymmetry|
|cardiac muscle tissue morphogenesis|
|vasculogenesis|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle organ development|
|positive regulation of gliogenesis|
|regulation of glial cell differentiation|
|regulation of sprouting angiogenesis|
|oligodendrocyte differentiation|
|epithelial to mesenchymal transition|
|positive regulation of muscle tissue development|
|chromatin DNA binding|
|positive regulation of small GTPase mediated signal transduction|
|hair follicle development|
|ventricular septum development|
|outflow tract morphogenesis|
|negative regulation of ossification|
|cardiac ventricle morphogenesis|
|cardiac septum morphogenesis|
|endoderm development|
|skin epidermis development|
|animal organ regeneration|
|hair cycle process|
|molting cycle process|
|embryonic heart tube development|
|regulation of transcription from RNA polymerase II promoter in response to hypoxia|
|nephron tubule development|
|regulation of cardiac muscle tissue development|
|muscle tissue morphogenesis|
|renal tubule development|
|positive regulation of animal organ morphogenesis|
|endothelial cell differentiation|
|mesenchymal cell development|
|regulation of epithelial to mesenchymal transition|
|positive regulation of receptor signaling pathway via JAK-STAT|
|regulation of hematopoietic progenitor cell differentiation|
|regulation of muscle adaptation|
|regulation of epidermis development|
|artery development|
|axis specification|
|muscle organ morphogenesis|
|acrosomal vesicle|
|regulation of neural precursor cell proliferation|
|regulation of BMP signaling pathway|
|positive regulation of receptor signaling pathway via STAT|
|cell fate specification|
|regulation of blood vessel endothelial cell migration|
|hair cycle|
|molting cycle|
|regulation of biomineral tissue development|
|regulation of biomineralization|
|regulation of viral genome replication|
|regulation of organ growth|
|endothelium development|
|columnar/cuboidal epithelial cell differentiation|
|nephron epithelium development|
|organ growth|
|gland morphogenesis|
|regulation of striated muscle cell differentiation|
|regulation of Notch signaling pathway|
|negative regulation of angiogenesis|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|negative regulation of blood vessel morphogenesis|
|spinal cord development|
|positive regulation of viral process|
|cardiac septum development|
|regulation of osteoblast differentiation|
|developmental growth involved in morphogenesis|
|negative regulation of vasculature development|
|cardiocyte differentiation|
|regulation of gliogenesis|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of stem cell differentiation|
|determination of left/right symmetry|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|skeletal muscle tissue development|
|determination of bilateral symmetry|
|nephron development|
|specification of symmetry|
|embryonic appendage morphogenesis|
|regulation of DNA-templated transcription in response to stress|
|Notch signaling pathway|
|liver development|
|embryonic limb morphogenesis|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|hepaticobiliary system development|
|regulation of embryonic development|
|kidney epithelium development|
|regulation of receptor signaling pathway via JAK-STAT|
|branching morphogenesis of an epithelial tube|
|digestive tract development|
|regulation of striated muscle tissue development|
|skeletal muscle organ development|
|regulation of receptor signaling pathway via STAT|
|stem cell population maintenance|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|transmembrane signaling receptor activity|
|maintenance of cell number|
|negative regulation of hemopoiesis|
|regulation of epithelial cell differentiation|
|digestive system development|
|regulation of cold-induced thermogenesis|
|regulation of viral life cycle|
|cell cycle arrest|
|tube formation|
|negative regulation of cellular response to growth factor stimulus|
|muscle cell development|
|appendage morphogenesis|
|limb morphogenesis|
|cytokine production|
|regulation of muscle cell differentiation|
|regeneration|
|mesenchymal cell differentiation|
|regulation of endothelial cell migration|
|stem cell differentiation|
|protein secretion|
|establishment of protein localization to extracellular region|
|morphogenesis of a branching epithelium|
|neural tube development|
|regulation of reproductive process|
|response to corticosteroid|
|cardiac muscle tissue development|
|regulation of regulated secretory pathway|
|protein localization to extracellular region|
|morphogenesis of a branching structure|
|lung development|
|cardiac chamber development|
|glial cell differentiation|
|positive regulation of developmental growth|
|respiratory tube development|
|peptide secretion|
|negative regulation of canonical Wnt signaling pathway|
|transcription initiation from RNA polymerase II promoter|
|appendage development|
|limb development|
|positive regulation of vasculature development|
|cellular response to hypoxia|
|positive regulation of epithelial cell proliferation|
|tissue homeostasis|
|regulation of ossification|
|epithelial cell development|
|inner ear development|
|respiratory system development|
|cellular response to decreased oxygen levels|
|homeostasis of number of cells|
|negative regulation of secretion by cell|
|receptor complex|
|regulation of viral process|
|negative regulation of Wnt signaling pathway|
|regulation of cell-substrate adhesion|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of chemotaxis|
|gliogenesis|
|cellular response to oxygen levels|
|DNA-templated transcription, initiation|
|anterior/posterior pattern specification|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of epithelial cell migration|
|ear development|
|mesenchyme development|
|regulation of exocytosis|
|connective tissue development|
|negative regulation of neuron differentiation|
|negative regulation of secretion|
|regulation of muscle system process|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of Ras protein signal transduction|
|negative regulation of growth|
|muscle cell differentiation|
|cell fate commitment|
|heart morphogenesis|
|regulation of animal organ morphogenesis|
|negative regulation of cell migration|
|positive regulation of growth|
|kidney development|
|regulation of cellular response to growth factor stimulus|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|keratinocyte differentiation|
|regulation of canonical Wnt signaling pathway|
|striated muscle tissue development|
|renal system development|
|regulation of angiogenesis|
|embryonic organ morphogenesis|
|negative regulation of neurogenesis|
|regulation of ERK1 and ERK2 cascade|
|muscle organ development|
|muscle tissue development|
|epithelial tube morphogenesis|
|negative regulation of cellular component movement|
|negative regulation of nervous system development|
|response to lipopolysaccharide|
|epidermal cell differentiation|
|angiogenesis|
|urogenital system development|
|apical plasma membrane|
|regulation of vasculature development|
|negative regulation of locomotion|
|multicellular organismal homeostasis|
|response to molecule of bacterial origin|
|response to steroid hormone|
|regulation of developmental growth|
|regionalization|
|regulation of epithelial cell proliferation|
|negative regulation of cell development|
|anatomical structure homeostasis|
|response to hypoxia|
|regulation of small GTPase mediated signal transduction|
|humoral immune response|
|cilium assembly|
|enzyme binding|
|response to decreased oxygen levels|
|regulation of Wnt signaling pathway|
|negative regulation of response to external stimulus|
|cilium organization|
|axonogenesis|
|in utero embryonic development|
|response to oxygen levels|
|skin development|
|forebrain development|
|developmental growth|
|growth|
|blood vessel morphogenesis|
|axon development|
|gland development|
|epidermis development|
|reproductive structure development|
|reproductive system development|
|morphogenesis of an epithelium|
|cell morphogenesis involved in neuron differentiation|
|embryonic organ development|
|pattern specification process|
|negative regulation of immune system process|
|plasma membrane bounded cell projection assembly|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of hemopoiesis|
|cell projection assembly|
|positive regulation of neurogenesis|
|response to peptide|
|muscle structure development|
|wound healing|
|neuron projection morphogenesis|
|transcription by RNA polymerase II|
|plasma membrane bounded cell projection morphogenesis|
|negative regulation of transport|
|blood vessel development|
|protein heterodimerization activity|
|cell projection morphogenesis|
|cell division|
|inflammatory response|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|positive regulation of multi-organism process|
|vasculature development|
|cell part morphogenesis|
|cardiovascular system development|
|positive regulation of cell motility|
|heart development|
|response to growth factor|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|spermatogenesis|
|sensory organ development|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|male gamete generation|
|tissue morphogenesis|
|embryonic morphogenesis|
|response to wounding|
|negative regulation of cell cycle|
|regulation of system process|
|cellular response to hormone stimulus|
|cell surface|
|Golgi membrane|
|chordate embryonic development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|tube morphogenesis|
|regulation of neuron differentiation|
|neuron projection development|
|developmental process involved in reproduction|
|regulation of growth|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|epithelial cell differentiation|
|response to bacterium|
|gamete generation|
|positive regulation of cell death|
|negative regulation of cellular component organization|
|negative regulation of cell differentiation|
|calcium ion binding|
|cell morphogenesis|
|brain development|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|organelle assembly|
|regulation of multi-organism process|
|head development|
|negative regulation of catalytic activity|
|regulation of secretion|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|regulation of cell migration|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|endoplasmic reticulum membrane|
|negative regulation of developmental process|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|multi-organism reproductive process|
|negative regulation of cell death|
|cell cycle process|
|response to organonitrogen compound|
|secretion by cell|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|export from cell|
|programmed cell death|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|cell death|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|epithelium development|
|secretion|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|cell projection organization|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|cell cycle|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|protein transport|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|peptide transport|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|amide transport|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|RNA metabolic process|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|nitrogen compound transport|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12529
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOTCH1 Expression in NALM6 Cells: 4.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>