NOV [The Human Chemical-Genetic Interaction Map Project]

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======= NOV =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCN3
  * **<color #00a2e8>Official Name</color>**: cellular communication network factor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4856|4856]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P48745|P48745]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOV&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOV|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/164958|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival (PubMed:15181016, PubMed:15611078, PubMed:12695522, PubMed:21344378, PubMed:12050162). Acts by binding to integrins or membrane receptors such as NOTCH1 (PubMed:12695522, PubMed:21344378, PubMed:15611078). Essential regulator of hematopoietic stem and progenitor cell function (PubMed:17463287). Inhibits myogenic differentiation through the activation of Notch-signaling pathway (PubMed:12050162). Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling (PubMed:20139355). Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival (PubMed:12695522). Plays also a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts (PubMed:15611078). Involved in bone regeneration as a negative regulator (By similarity). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (PubMed:21871891). Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti- inflammatory effects occur secondary to the inhibition of NF- kappaB signaling pathway (PubMed:21063504). Contributes to the control and coordination of inflammatory processes in atherosclerosis (By similarity). Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement (PubMed:21871891). {ECO:0000250|UniProtKB:Q64299, ECO:0000269|PubMed:12050162, ECO:0000269|PubMed:12695522, ECO:0000269|PubMed:15181016, ECO:0000269|PubMed:15611078, ECO:0000269|PubMed:17463287, ECO:0000269|PubMed:20139355, ECO:0000269|PubMed:21063504, ECO:0000269|PubMed:21344378, ECO:0000269|PubMed:21871891}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IGFBP|
|Cys knot|
|VWC|
|TSP 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of sensory perception of pain|
|smooth muscle cell proliferation|
|negative regulation of chondrocyte proliferation|
|endothelial cell-cell adhesion|
|bone regeneration|
|hematopoietic stem cell homeostasis|
|negative regulation of SMAD protein signal transduction|
|negative regulation of monocyte chemotaxis|
|negative regulation of mononuclear cell migration|
|fibroblast migration|
|endothelial cell chemotaxis|
|smooth muscle cell migration|
|type B pancreatic cell proliferation|
|epithelial cell-cell adhesion|
|gap junction|
|negative regulation of leukocyte chemotaxis|
|muscle cell proliferation|
|negative regulation of myotube differentiation|
|insulin-like growth factor binding|
|regulation of SMAD protein signal transduction|
|negative regulation of NIK/NF-kappaB signaling|
|muscle cell migration|
|cell adhesion mediated by integrin|
|regulation of monocyte chemotaxis|
|negative regulation of nervous system process|
|Notch binding|
|negative regulation of striated muscle cell differentiation|
|negative regulation of insulin secretion|
|regulation of sensory perception of pain|
|regulation of sensory perception|
|negative regulation of peptide hormone secretion|
|negative regulation of leukocyte migration|
|regulation of mononuclear cell migration|
|positive regulation of Notch signaling pathway|
|negative regulation of muscle cell differentiation|
|regulation of myotube differentiation|
|negative regulation of chemotaxis|
|negative regulation of hormone secretion|
|tissue regeneration|
|endothelial cell migration|
|chondrocyte differentiation|
|epithelial cell migration|
|epithelial cell proliferation|
|epithelium migration|
|tissue migration|
|regulation of striated muscle cell differentiation|
|regulation of Notch signaling pathway|
|regulation of NIK/NF-kappaB signaling|
|regulation of leukocyte chemotaxis|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|integrin binding|
|negative regulation of protein secretion|
|negative regulation of inflammatory response|
|regulation of nervous system process|
|negative regulation of peptide secretion|
|regulation of muscle cell differentiation|
|regeneration|
|growth factor activity|
|heparin binding|
|cartilage development|
|ameboidal-type cell migration|
|regulation of insulin secretion|
|negative regulation of protein transport|
|negative regulation of cell growth|
|negative regulation of establishment of protein localization|
|regulation of leukocyte migration|
|homeostasis of number of cells|
|negative regulation of secretion by cell|
|negative regulation of defense response|
|regulation of peptide hormone secretion|
|cell chemotaxis|
|regulation of chemotaxis|
|connective tissue development|
|extracellular matrix|
|negative regulation of secretion|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|negative regulation of growth|
|negative regulation of cell migration|
|regulation of hormone secretion|
|negative regulation of cell motility|
|axon|
|negative regulation of cellular component movement|
|angiogenesis|
|negative regulation of locomotion|
|regulation of inflammatory response|
|collagen-containing extracellular matrix|
|negative regulation of response to external stimulus|
|neuronal cell body|
|developmental growth|
|growth|
|blood vessel morphogenesis|
|regulation of cell growth|
|dendrite|
|negative regulation of immune system process|
|regulation of protein secretion|
|wound healing|
|negative regulation of transport|
|blood vessel development|
|skeletal system development|
|regulation of peptide secretion|
|cell-cell adhesion|
|negative regulation of intracellular signal transduction|
|vasculature development|
|cardiovascular system development|
|regulation of hormone levels|
|chemotaxis|
|taxis|
|cell population proliferation|
|response to wounding|
|regulation of system process|
|tube morphogenesis|
|regulation of growth|
|negative regulation of cell population proliferation|
|intracellular membrane-bounded organelle|
|regulation of protein transport|
|negative regulation of cell differentiation|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|regulation of secretion|
|tube development|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|cell migration|
|regulation of locomotion|
|negative regulation of cell death|
|regulation of cellular component movement|
|regulation of protein localization|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|movement of cell or subcellular component|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|tissue development|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of transport|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.604|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10766
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOV Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>