NPIPA5 [The Human Chemical-Genetic Interaction Map Project]

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======= NPIPA5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NPIPA5
  * **<color #00a2e8>Official Name</color>**: nuclear pore complex interacting protein family member A5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=100288332|100288332]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/E9PKD4|E9PKD4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NPIPA5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NPIPA5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NPIP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.1|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-1.99|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.93|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-1.86|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.8|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.73|
|[[:results:exp136|MS094 2μM R03 exp136]]|-1.7|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|1.73|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|1.73|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.74|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|1.76|
|[[:results:exp303|39°C R06 exp303]]|1.81|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|1.81|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.83|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|1.85|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.9|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|1.92|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|1.93|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|1.96|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|1.99|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|2.07|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|2.13|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|2.48|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|2.5|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|3.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cactin|CACTIN]]|0.412|
|[[:human genes:r:rrm1|RRM1]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2054
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NPIPA5 Expression in NALM6 Cells: 7.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>