NPIPB11 [The Human Chemical-Genetic Interaction Map Project]

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======= NPIPB11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NPIPB11
  * **<color #00a2e8>Official Name</color>**: nuclear pore complex interacting protein family member B11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=728888|728888]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/E5RHQ5|E5RHQ5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NPIPB11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NPIPB11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NPIP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-2.02|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.73|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.7|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|1.7|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|1.73|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|1.75|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|1.87|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.9|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|1.99|
|[[:results:exp292|Menadione 5μM R06 exp292]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rpl35|RPL35]]|0.469|
|[[:human genes:c:chchd3|CHCHD3]]|0.454|
|[[:human genes:l:lad1|LAD1]]|0.426|
|[[:human genes:p:pole|POLE]]|0.423|
|[[:human genes:i:igfn1|IGFN1]]|0.421|
|[[:human genes:n:narfl|NARFL]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2263
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NPIPB11 Expression in NALM6 Cells: 4.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>