NPIPB4 [The Human Chemical-Genetic Interaction Map Project]

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======= NPIPB4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NPIPB4
  * **<color #00a2e8>Official Name</color>**: nuclear pore complex interacting protein family member B4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=440345|440345]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/C9JG80|C9JG80]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NPIPB4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NPIPB4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NPIP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.98|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.89|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.85|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.81|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-1.81|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.8|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-1.78|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.72|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|1.72|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|1.77|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.99|
|[[:results:exp149|SB203580 25μM R03 exp149]]|2.04|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.582|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.469|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.449|
|[[:human genes:t:top1mt|TOP1MT]]|0.442|
|[[:human genes:k:kctd17|KCTD17]]|0.428|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2104
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NPIPB4 Expression in NALM6 Cells: 7.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>