NPLOC4 [The Human Chemical-Genetic Interaction Map Project]

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======= NPLOC4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NPLOC4
  * **<color #00a2e8>Official Name</color>**: NPL4 homolog, ubiquitin recognition factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55666|55666]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TAT6|Q8TAT6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NPLOC4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NPLOC4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606590|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729). {ECO:0000250|UniProtKB:Q9ES54, ECO:0000269|PubMed:26471729}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UN NPL4|
|zf-NPL4|
|NPL4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|UFD1-NPL4 complex|
|nuclear outer membrane-endoplasmic reticulum membrane network|
|VCP-NPL4-UFD1 AAA ATPase complex|
|negative regulation of RIG-I signaling pathway|
|negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway|
|retrograde protein transport, ER to cytosol|
|regulation of RIG-I signaling pathway|
|endoplasmic reticulum to cytosol transport|
|error-free translesion synthesis|
|regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway|
|negative regulation of defense response to virus|
|protein exit from endoplasmic reticulum|
|translesion synthesis|
|negative regulation of type I interferon production|
|DNA synthesis involved in DNA repair|
|postreplication repair|
|ubiquitin-dependent ERAD pathway|
|regulation of defense response to virus|
|ubiquitin binding|
|ERAD pathway|
|negative regulation of response to biotic stimulus|
|DNA biosynthetic process|
|negative regulation of immune effector process|
|regulation of type I interferon production|
|Golgi organization|
|negative regulation of defense response|
|negative regulation of multi-organism process|
|response to endoplasmic reticulum stress|
|negative regulation of cytokine production|
|ubiquitin protein ligase binding|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|negative regulation of response to external stimulus|
|endomembrane system organization|
|negative regulation of immune system process|
|regulation of innate immune response|
|regulation of immune effector process|
|negative regulation of intracellular signal transduction|
|DNA repair|
|regulation of response to biotic stimulus|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|regulation of cytokine production|
|DNA metabolic process|
|regulation of defense response|
|cellular response to DNA damage stimulus|
|regulation of multi-organism process|
|cellular macromolecule catabolic process|
|intracellular protein transport|
|response to organonitrogen compound|
|endoplasmic reticulum|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|regulation of immune response|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|proteolysis|
|organic cyclic compound biosynthetic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|regulation of immune system process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.73|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.7|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.72|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.76|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.94|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|2.06|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|2.46|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 599/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|19/28|
|blood|27/28|
|bone|24/26|
|breast|29/33|
|central nervous system|48/56|
|cervix|4/4|
|colorectal|15/17|
|esophagus|8/13|
|fibroblast|1/1|
|gastric|13/16|
|kidney|17/21|
|liver|16/20|
|lung|57/75|
|lymphocyte|13/16|
|ovary|21/26|
|pancreas|18/24|
|peripheral nervous system|9/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|18/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|13/22|
|urinary tract|22/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 936
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NPLOC4 Expression in NALM6 Cells: 6.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>