NPM2 [The Human Chemical-Genetic Interaction Map Project]

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======= NPM2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NPM2
  * **<color #00a2e8>Official Name</color>**: nucleophosmin/nucleoplasmin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10361|10361]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86SE8|Q86SE8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NPM2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NPM2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608073|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization. {ECO:0000269|PubMed:21863821}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nucleoplasmin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytoplasmic chromatin|
|positive regulation of meiotic nuclear division|
|regulation of exit from mitosis|
|positive regulation of meiotic cell cycle|
|regulation of meiotic nuclear division|
|positive regulation of DNA replication|
|oocyte differentiation|
|regulation of meiotic cell cycle|
|positive regulation of nuclear division|
|oogenesis|
|positive regulation of reproductive process|
|blastocyst development|
|regulation of DNA replication|
|female gamete generation|
|histone binding|
|single fertilization|
|regulation of reproductive process|
|chromatin remodeling|
|regulation of mitotic nuclear division|
|fertilization|
|regulation of nuclear division|
|positive regulation of DNA metabolic process|
|nuclear chromatin|
|germ cell development|
|positive regulation of cell cycle process|
|protein homooligomerization|
|enzyme binding|
|cellular process involved in reproduction in multicellular organism|
|regulation of DNA metabolic process|
|positive regulation of cell cycle|
|in utero embryonic development|
|chromatin binding|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|protein complex oligomerization|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|gamete generation|
|chromatin organization|
|regulation of cell cycle process|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|nucleolus|
|embryo development|
|multi-organism reproductive process|
|chromosome organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|protein-containing complex assembly|
|cell development|
|positive regulation of molecular function|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7865
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.57 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NPM2 Expression in NALM6 Cells: -1.57'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>