NPR1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= NPR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NPR1
  * **<color #00a2e8>Official Name</color>**: natriuretic peptide receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4881|4881]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P16066|P16066]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NPR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NPR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/108960|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand. {ECO:0000269|PubMed:1672777}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
|Guanylate cyc|
|ANF receptor|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|natriuretic peptide receptor activity|
|peptide receptor activity|
|positive regulation of cGMP-mediated signaling|
|guanylate cyclase activity|
|receptor guanylyl cyclase signaling pathway|
|hormone binding|
|cGMP biosynthetic process|
|positive regulation of renal sodium excretion|
|regulation of cGMP-mediated signaling|
|positive regulation of urine volume|
|cGMP metabolic process|
|regulation of renal sodium excretion|
|regulation of urine volume|
|cyclic nucleotide biosynthetic process|
|cyclic purine nucleotide metabolic process|
|regulation of excretion|
|cGMP-mediated signaling|
|dopamine metabolic process|
|regulation of renal system process|
|regulation of vascular permeability|
|peptide hormone binding|
|G protein-coupled peptide receptor activity|
|cyclic nucleotide metabolic process|
|catechol-containing compound metabolic process|
|catecholamine metabolic process|
|negative regulation of smooth muscle cell proliferation|
|regulation of cardiac conduction|
|body fluid secretion|
|phenol-containing compound metabolic process|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|renal system process|
|negative regulation of vasculature development|
|regulation of smooth muscle cell proliferation|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|vascular process in circulatory system|
|purine-containing compound biosynthetic process|
|cyclic-nucleotide-mediated signaling|
|regulation of blood pressure|
|negative regulation of cell growth|
|ammonium ion metabolic process|
|receptor complex|
|protein kinase activity|
|regulation of heart contraction|
|negative regulation of growth|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|regulation of angiogenesis|
|regulation of blood circulation|
|purine ribonucleotide metabolic process|
|regulation of vasculature development|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|second-messenger-mediated signaling|
|purine-containing compound metabolic process|
|GTP binding|
|blood circulation|
|circulatory system process|
|regulation of cell growth|
|positive regulation of secretion|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic hydroxy compound metabolic process|
|protein kinase binding|
|regulation of body fluid levels|
|drug metabolic process|
|regulation of anatomical structure size|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|regulation of system process|
|carbohydrate derivative biosynthetic process|
|regulation of growth|
|negative regulation of cell population proliferation|
|enzyme linked receptor protein signaling pathway|
|regulation of secretion|
|organophosphate metabolic process|
|negative regulation of developmental process|
|protein phosphorylation|
|positive regulation of transport|
|positive regulation of intracellular signal transduction|
|carbohydrate derivative metabolic process|
|regulation of anatomical structure morphogenesis|
|nucleobase-containing compound biosynthetic process|
|secretion|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of multicellular organismal process|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|G protein-coupled receptor signaling pathway|
|organonitrogen compound biosynthetic process|
|ATP binding|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8356
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NPR1 Expression in NALM6 Cells: -3.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>