NPY2R [The Human Chemical-Genetic Interaction Map Project]

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======= NPY2R =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NPY2R
  * **<color #00a2e8>Official Name</color>**: neuropeptide Y receptor Y2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4887|4887]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49146|P49146]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NPY2R&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NPY2R|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/162642|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu- 31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
|7TM GPCR Srsx|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peptide YY receptor activity|
|positive regulation of circadian sleep/wake cycle, non-REM sleep|
|positive regulation of circadian sleep/wake cycle, sleep|
|positive regulation of dopamine secretion|
|regulation of circadian sleep/wake cycle, non-REM sleep|
|negative regulation of synaptic transmission, glutamatergic|
|negative regulation of feeding behavior|
|neuropeptide Y receptor activity|
|negative regulation of excitatory postsynaptic potential|
|positive regulation of catecholamine secretion|
|cardiac left ventricle morphogenesis|
|positive regulation of circadian rhythm|
|negative regulation of behavior|
|regulation of circadian sleep/wake cycle, sleep|
|nitric oxide mediated signal transduction|
|regulation of circadian sleep/wake cycle|
|negative regulation of cAMP-mediated signaling|
|negative regulation of nervous system process|
|positive regulation of behavior|
|regulation of feeding behavior|
|behavioral fear response|
|positive regulation of response to drug|
|behavioral defense response|
|positive regulation of smooth muscle contraction|
|non-motile cilium|
|fear response|
|positive regulation of amine transport|
|calcium channel regulator activity|
|regulation of sensory perception of pain|
|modulation of excitatory postsynaptic potential|
|regulation of dopamine secretion|
|regulation of sensory perception|
|positive regulation of muscle contraction|
|regulation of cAMP-mediated signaling|
|regulation of smooth muscle contraction|
|negative regulation of synaptic transmission|
|regulation of catecholamine secretion|
|multicellular organismal response to stress|
|regulation of synaptic transmission, glutamatergic|
|regulation of behavior|
|cardiac ventricle morphogenesis|
|outflow tract morphogenesis|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|regulation of amine transport|
|regulation of response to drug|
|neuropeptide signaling pathway|
|regulation of circadian rhythm|
|positive regulation of cell-substrate adhesion|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|regulation of nervous system process|
|regulation of muscle contraction|
|cardiac chamber development|
|locomotory behavior|
|cilium|
|signaling receptor activity|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|regulation of cell-substrate adhesion|
|negative regulation of secretion|
|regulation of muscle system process|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|heart morphogenesis|
|positive regulation of ion transport|
|aging|
|positive regulation of cytosolic calcium ion concentration|
|positive regulation of peptide secretion|
|regulation of cytosolic calcium ion concentration|
|second-messenger-mediated signaling|
|positive regulation of secretion by cell|
|positive regulation of cell adhesion|
|regulation of membrane potential|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|negative regulation of intracellular signal transduction|
|heart development|
|cellular metal ion homeostasis|
|behavior|
|regulation of system process|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|regulation of cell adhesion|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|ion homeostasis|
|regulation of secretion|
|circulatory system development|
|cellular homeostasis|
|animal organ morphogenesis|
|positive regulation of transport|
|chemical homeostasis|
|secretion|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|G protein-coupled receptor signaling pathway|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|integral component of plasma membrane|
|negative regulation of response to stimulus|
|homeostatic process|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|regulation of intracellular signal transduction|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12136
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NPY2R Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>