NPY5R [The Human Chemical-Genetic Interaction Map Project]

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======= NPY5R =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NPY5R
  * **<color #00a2e8>Official Name</color>**: neuropeptide Y receptor Y5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4889|4889]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15761|Q15761]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NPY5R&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NPY5R|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602001|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srsx|
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|generation of ovulation cycle rhythm|
|peptide YY receptor activity|
|pancreatic polypeptide receptor activity|
|negative regulation of glutamate secretion|
|negative regulation of acute inflammatory response to antigenic stimulus|
|negative regulation of synaptic transmission, GABAergic|
|neuropeptide Y receptor activity|
|negative regulation of amino acid transport|
|negative regulation of inflammatory response to antigenic stimulus|
|negative regulation of acute inflammatory response|
|regulation of acute inflammatory response to antigenic stimulus|
|cardiac left ventricle morphogenesis|
|regulation of glutamate secretion|
|negative regulation of organic acid transport|
|regulation of inflammatory response to antigenic stimulus|
|negative regulation of amine transport|
|negative regulation of anion transport|
|positive regulation of acute inflammatory response|
|eating behavior|
|regulation of amino acid transport|
|regulation of synaptic transmission, GABAergic|
|ovulation cycle process|
|regulation of acute inflammatory response|
|regulation of organic acid transport|
|negative regulation of synaptic transmission|
|ovulation cycle|
|outflow tract morphogenesis|
|cardiac ventricle morphogenesis|
|feeding behavior|
|positive regulation of smooth muscle cell proliferation|
|regulation of amine transport|
|regulation of anion transport|
|neuropeptide signaling pathway|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|regulation of smooth muscle cell proliferation|
|negative regulation of inflammatory response|
|positive regulation of inflammatory response|
|negative regulation of ion transport|
|negative regulation of immune response|
|cardiac chamber development|
|negative regulation of secretion by cell|
|negative regulation of defense response|
|positive regulation of ERK1 and ERK2 cascade|
|negative regulation of secretion|
|heart morphogenesis|
|rhythmic process|
|aging|
|regulation of ERK1 and ERK2 cascade|
|neuron projection|
|regulation of inflammatory response|
|negative regulation of response to external stimulus|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|trans-synaptic signaling|
|negative regulation of immune system process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|positive regulation of defense response|
|negative regulation of transport|
|heart development|
|positive regulation of MAPK cascade|
|behavior|
|positive regulation of response to external stimulus|
|regulation of ion transport|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|regulation of secretion|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|circulatory system development|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|animal organ morphogenesis|
|negative regulation of cell death|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of response to external stimulus|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of protein modification process|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp462|Cadmium 60μM R08 exp462]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12805
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NPY5R Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>