NQO2 [The Human Chemical-Genetic Interaction Map Project]

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======= NQO2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NQO2
  * **<color #00a2e8>Official Name</color>**: N-ribosyldihydronicotinamide:quinone reductase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4835|4835]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P16083|P16083]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NQO2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NQO2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/160998|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. {ECO:0000269|PubMed:18254726}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Flavodoxin 2|
|FMN red|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|melatonin binding|
|resveratrol binding|
|dihydronicotinamide riboside quinone reductase activity|
|oxidoreductase activity, acting on other nitrogenous compounds as donors|
|NAD(P)H dehydrogenase (quinone) activity|
|chloride ion binding|
|FAD binding|
|positive regulation of vascular smooth muscle cell proliferation|
|regulation of vascular smooth muscle cell proliferation|
|positive regulation of neuron apoptotic process|
|electron transfer activity|
|positive regulation of smooth muscle cell proliferation|
|positive regulation of neuron death|
|positive regulation of reactive oxygen species metabolic process|
|memory|
|oxidoreductase activity|
|xenobiotic metabolic process|
|regulation of smooth muscle cell proliferation|
|regulation of reactive oxygen species metabolic process|
|electron transport chain|
|cellular response to xenobiotic stimulus|
|regulation of neuron apoptotic process|
|positive regulation of ERK1 and ERK2 cascade|
|learning or memory|
|regulation of ERK1 and ERK2 cascade|
|cognition|
|response to xenobiotic stimulus|
|regulation of neuron death|
|generation of precursor metabolites and energy|
|positive regulation of MAPK cascade|
|behavior|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|regulation of MAPK cascade|
|zinc ion binding|
|protein homodimerization activity|
|positive regulation of cell population proliferation|
|oxidation-reduction process|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of protein modification process|
|nervous system process|
|regulation of protein phosphorylation|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17770
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NQO2 Expression in NALM6 Cells: 4.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>