NR2C2AP [The Human Chemical-Genetic Interaction Map Project]

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======= NR2C2AP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NR2C2AP
  * **<color #00a2e8>Official Name</color>**: nuclear receptor 2C2 associated protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=126382|126382]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86WQ0|Q86WQ0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NR2C2AP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NR2C2AP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608719|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes. {ECO:0000269|PubMed:12486131}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|F5 F8 type C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transcription initiation from RNA polymerase II promoter|
|DNA-templated transcription, initiation|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.06|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|-1.78|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.77|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.73|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.72|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|-1.71|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|1.71|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.72|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.72|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.76|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.79|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|1.8|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.8|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.83|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.86|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.88|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|1.91|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|1.93|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.03|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.09|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.21|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|2.21|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|2.28|
|[[:results:exp495|IWR1 50μM R08 exp495]]|2.32|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.37|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|2.39|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.51|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.71|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.94|
|[[:results:exp134|MS023 2μM R03 exp134]]|4.27|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kti12|KTI12]]|0.651|
|[[:human genes:e:elp6|ELP6]]|0.57|
|[[:human genes:c:ctu1|CTU1]]|0.55|
|[[:human genes:e:elp2|ELP2]]|0.536|
|[[:human genes:c:ctu2|CTU2]]|0.516|
|[[:human genes:d:dph3|DPH3]]|0.507|
|[[:human genes:i:ikbkap|IKBKAP]]|0.494|
|[[:human genes:m:mocs3|MOCS3]]|0.492|
|[[:human genes:e:elp3|ELP3]]|0.467|
|[[:human genes:e:elp5|ELP5]]|0.465|
|[[:human genes:u:urm1|URM1]]|0.464|
|[[:human genes:a:alkbh8|ALKBH8]]|0.461|
|[[:human genes:d:dph5|DPH5]]|0.427|
|[[:human genes:f:fam98b|FAM98B]]|0.425|
|[[:human genes:p:prim1|PRIM1]]|0.418|
|[[:human genes:c:c7orf26|C7orf26]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 74/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|0/28|
|bone|6/26|
|breast|4/33|
|central nervous system|9/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|2/21|
|liver|5/20|
|lung|6/75|
|lymphocyte|0/16|
|ovary|3/26|
|pancreas|0/24|
|peripheral nervous system|3/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|5/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2529
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NR2C2AP Expression in NALM6 Cells: 4.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>