NRF1 [The Human Chemical-Genetic Interaction Map Project]

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======= NRF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NRF1
  * **<color #00a2e8>Official Name</color>**: nuclear respiratory factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4899|4899]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16656|Q16656]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NRF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NRF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600879|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nrf1 DNA-bind|
|Nrf1 activ bdg|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|core promoter sequence-specific DNA binding|
|RNA polymerase II core promoter sequence-specific DNA binding|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|protein homodimerization activity|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.9|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|1.7|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|1.82|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.84|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|1.85|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.94|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.05|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|2.06|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.08|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.492|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 497/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|21/28|
|blood|20/28|
|bone|17/26|
|breast|22/33|
|central nervous system|37/56|
|cervix|3/4|
|colorectal|12/17|
|esophagus|9/13|
|fibroblast|1/1|
|gastric|11/16|
|kidney|12/21|
|liver|8/20|
|lung|58/75|
|lymphocyte|12/16|
|ovary|18/26|
|pancreas|20/24|
|peripheral nervous system|12/16|
|plasma cell|8/15|
|prostate|0/1|
|skin|12/24|
|soft tissue|6/9|
|thyroid|1/2|
|upper aerodigestive|13/22|
|urinary tract|16/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 712
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NRF1 Expression in NALM6 Cells: 4.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>