NRG2 [The Human Chemical-Genetic Interaction Map Project]

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======= NRG2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NRG2
  * **<color #00a2e8>Official Name</color>**: neuregulin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9542|9542]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14511|O14511]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NRG2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NRG2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603818|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ig|
|I-set|
|Neuregulin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ERBB2 signaling pathway|
|ERBB signaling pathway|
|growth factor activity|
|positive regulation of protein kinase B signaling|
|regulation of protein kinase B signaling|
|signaling receptor binding|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|enzyme linked receptor protein signaling pathway|
|regulation of cell motility|
|protein phosphorylation|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of intracellular signal transduction|
|phosphorylation|
|extracellular space|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-1.94|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.81|
|[[:results:exp132|Metformin 40μM R03 exp132]]|-1.75|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.76|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.433|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4745
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.91 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NRG2 Expression in NALM6 Cells: -0.91'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>